Results 1 to 10 of about 17,124 (205)

Design and in silico evaluation of Thiazole–Isoxazole hybrids as PPARγ-Targeted antidiabetic agents [PDF]

Frontiers in Bioinformatics
IntroductionDiabetes mellitus is a chronic metabolic disorder characterised by persistent hyperglycemia resulting from impaired insulin secretion, action, or both.
Abhirami PV, Gupta Dheeraj Rajesh, N. V. L. Sirisha Mulukuri, Ranjitha A, Niyas Rehman, Shiv Basant Kumar, Dileep Kumar, Pankaj Kumar   +7 more
doaj   +2 more sources

Design, synthesis, and biological evaluation of novel aryl isoxazoles as potential Hsp90 inhibitors [PDF]

Research in Pharmaceutical Sciences
Background and purpose: Heat shock protein 90 (Hsp90) is a molecular chaperone critical for the stabilization of numerous oncoproteins, making it a promising target for anticancer drug development.
Mina Ardestani, Fariba Keshavarzipour, Maryam Abbasi, Afshin Zarghi, Mahmoud Aghaei, Mehran Ghiaci, Hojjat Sadeghi-Aliabadi   +6 more
doaj   +2 more sources

Synthesis, chemo-informatics, and anticancer evaluation of fluorophenyl-isoxazole derivatives

Open Chemistry, 2021
The current study aimed to design and synthesize a novel series of fluorophenyl-isoxazole-carboxamide derivatives and evaluate their antiproliferative activities.
Mohammed Hawash, Johnny Amer, Murad Abualhasan   +2 more
exaly   +2 more sources

Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates [PDF]

Molecules
In this study, the synthesis of a series of alkaloid analogs—isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method.
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Zharkyn Zh. Zhumagaliyeva, Gulzhaukhar A. Toktarbay, Irina A. Kolesnik, Ekaterina A. Akishina, Evgenij A. Dikusar, Vladimir I. Potkin, Aliaksandr L. Pushkarchuk, Tatiana I. Terpinskaya, Fedor I. Zubkov, Mikhail S. Grigoriev, Hongwei Zhou   +12 more
doaj   +2 more sources

Phenylisoxazole-3/5-Carbaldehyde Isonicotinylhydrazone Derivatives: Synthesis, Characterization, and Antitubercular Activity

Journal of Chemistry, 2021
Eight new phenylisoxazole isoniazid derivatives, 3-(2′-fluorophenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (1), 3-(2′-methoxyphenyl)isoxazole-5-carbaldehyde isonicotinylhydrazone (2), 3-(2′-chlorophenyl)isoxazole-5-carbaldehyde ...
Fernando Carrasco, Wilfredo Hernández, Oscar Chupayo, Patricia Sheen, Mirko Zimic, Jorge Coronel, Celedonio M. Álvarez, Sergio Ferrero, Sandra Oramas-Royo, Evgenia Spodine, Jesus M. Rodilla, Juan Z. Dávalos   +11 more
doaj   +1 more source

Synthesis of Spiro Pyrazolone-Oxindole and Bicyclic Pyrazolone Derivatives via Solvent-Dependent Regioselective Aza-1,4/1,6-Michael and Intramolecular Cycloaddition under Catalyst-Free Conditions

SynOpen, 2021
A solvent-dependent, highly regioselective [3+2]-cyclo­addition reaction of isoxazole-styrenes and azomethine imines under catalyst-free conditions is reported, furnishing a library of pyrazolone–spirooxindole hybrids.
Kota Sathish, Sakkani Nagaraju, Dhurke Kashinath   +2 more
doaj   +1 more source

Simple Access to Isoxazole-Containing Heterocyclic Hybrids: Isoxazole/Oxazole and Isoxazole/Pyridine

Russian Journal of General Chemistry, 2023
Abstract The synthesis of substituted isoxazole–oxazole hybrids by the noncatalytic reaction of methyl 2-diazo-2-(alkyl/aryl/hetarylisoxazol-5-yl)acetates with alkyl and aryl cyanides has been reported. According to DFT calculations, the reaction proceeds through the intermediate formation
A. E. Taishev, E. E. Galenko, M. S. Novikov, A. F. Khlebnikov   +3 more
openaire   +1 more source

Lewis acid-promoted direct synthesis of isoxazole derivatives

Beilstein Journal of Organic Chemistry, 2023
Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive.
Dengxu Qiu, Chenhui Jiang, Pan Gao, Yu Yuan   +3 more
doaj   +1 more source

(3-Methyl-3a,4,7,7a-tetrahydro-5H-4,7-methanoisoxazolo[4,5-d][1,2]oxazin-5-yl)(phenyl)methanone

Acta Crystallographica Section E, 2014
The title compound, C14H14N2O3, is the exo isomer with a syn arrangement of two O atoms in the isoxazole and oxazine rings. The dihedral angle between the isoxazole and phenyl rings is 60.38 (4)°.
Alan J. Lough, Jaipal R. Nagireddy, William Tam   +2 more
doaj   +1 more source

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds

Molecules, 2023
The biological significance of benzopyran-4-ones as cytotoxic agents against multi-drug resistant cancer cell lines and isoxazoles as anti-inflammatory agents in cellular assays prompted us to design and synthesize their hybrid compounds and explore ...
Shilpi Gupta, Shang Eun Park, Saghar Mozaffari, Bishoy El-Aarag, Keykavous Parang, Rakesh Kumar Tiwari   +5 more
doaj   +1 more source