Results 11 to 20 of about 17,613 (213)

5-(Benzoyloxymethyl)isoxazole-3-carboxylic Acid Ethyl Ester

Molbank
We describe here the palladium hydrogenation of ethyl 5-(benzoyloxymethyl)isoxazole-3-carboxylate. The presence of two reducible sites in the molecule, namely the benzylic-like position and the isoxazole N–O bond, creates a possible competition.
Cosimo Antonini, Franca M. Cordero, Fabrizio Machetti   +2 more
doaj   +2 more sources

Design and in silico evaluation of Thiazole–Isoxazole hybrids as PPARγ-Targeted antidiabetic agents [PDF]

Frontiers in Bioinformatics
IntroductionDiabetes mellitus is a chronic metabolic disorder characterised by persistent hyperglycemia resulting from impaired insulin secretion, action, or both.
Abhirami PV, Gupta Dheeraj Rajesh, N. V. L. Sirisha Mulukuri, Ranjitha A, Niyas Rehman, Shiv Basant Kumar, Dileep Kumar, Pankaj Kumar   +7 more
doaj   +2 more sources

Design, synthesis, and biological evaluation of novel aryl isoxazoles as potential Hsp90 inhibitors [PDF]

Research in Pharmaceutical Sciences
Background and purpose: Heat shock protein 90 (Hsp90) is a molecular chaperone critical for the stabilization of numerous oncoproteins, making it a promising target for anticancer drug development.
Mina Ardestani, Fariba Keshavarzipour, Maryam Abbasi, Afshin Zarghi, Mahmoud Aghaei, Mehran Ghiaci, Hojjat Sadeghi-Aliabadi   +6 more
doaj   +2 more sources

Advances in Isoxazole-Containing Anticancer Drugs: From Synthesis to Clinical Potential

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
Cancer is one of the most common and deadly diseases worldwide, and the development of new therapeutic strategies to overcome treatment resistance and improve clinical outcomes remains a critical challenge.
Nurcan Berber
doaj   +2 more sources

The Green and Effective Synthesis of Isoxazole-Based Molecules Under Ultrasonic Irradiation Approaches

Pharmaceuticals
Isoxazole-based molecules constitute a crucial category of heterocyclic compounds with wide-ranging applications across pharmaceutical development, advanced materials, and pesticide synthesis.
Mei-Tong Chen, Yao-Rong Li, Zhao-Qi Wang, Shan Jiang, Zan-Hui Jia, Da-Wei Zhang   +5 more
doaj   +2 more sources

Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates [PDF]

Molecules
In this study, the synthesis of a series of alkaloid analogs—isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method.
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Zharkyn Zh. Zhumagaliyeva, Gulzhaukhar A. Toktarbay, Irina A. Kolesnik, Ekaterina A. Akishina, Evgenij A. Dikusar, Vladimir I. Potkin, Aliaksandr L. Pushkarchuk, Tatiana I. Terpinskaya, Fedor I. Zubkov, Mikhail S. Grigoriev, Hongwei Zhou   +12 more
doaj   +2 more sources

Molecular modeling, synthesis, and antiproliferative evaluation of new isoxazole ring linked by Schiff bases and azo bond

Journal of Advanced Pharmaceutical Technology & Research, 2023
Lung cancer is the most common malignancy worldwide, with approximately 1.8 million new cases yearly. Cytotoxic drugs are frequently used in cancer treatment.
Duha E Taha, Monther F Mahdi, Ayad M. R. Raauf   +2 more
doaj   +1 more source

1-Methyl-3-(2-methylphenyl)-3,3a,4,9b-tetrahydro-1H-chromeno[4,3-c][1,2]oxazole-3a-carbonitrile

Acta Crystallographica Section E, 2011
In the title compound, C19H18N2O2, the five-membered isoxazole ring adopts an envelope conformation and the deviation of the N atom from the mean plane of the isoxazole ring is −0.3256 (11) Å.
K. Swaminathan, K. Sethusankar, G. Murugan, M. Bakthadoss   +3 more
doaj   +1 more source

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-c][1,2,4]Triazines: Synthesis and Photochemical Properties

Molecules, 2023
New fluorescent dyes containing an assembled 1,4-dihydroazolo[5,1-c][1,2,4]triazine (DAT) core and an isoxazole ring were synthesized through a reaction between diazopyrazole or diazoimidazoles and isoxazolyl-derived enamines in mild conditions.
Elena V. Sadchikova, Nikita E. Safronov, Nikolai A. Beliaev, Valentine G. Nenajdenko, Nataliya P. Belskaya   +4 more
doaj   +1 more source

Synthesis and characterization of selected fused isoxazole and pyrazole derivatives and their antimicrobial activity [PDF]

Journal of the Serbian Chemical Society, 2009
New potent antibacterials, fused isoxazole and pyrazole derivatives, were synthesized using 5,5-dimethylcyclohexane-1,3-dione (1) and 3-[(4-chlorobenzylidene) amino]-2-thioxoimidazolidin-4-one (2) as synthons.
Dabholkar Vijay V., Ansari Faisal Y.
doaj   +3 more sources