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5-(Benzoyloxymethyl)isoxazole-3-carboxylic Acid Ethyl Ester
MolbankWe describe here the palladium hydrogenation of ethyl 5-(benzoyloxymethyl)isoxazole-3-carboxylate. The presence of two reducible sites in the molecule, namely the benzylic-like position and the isoxazole N–O bond, creates a possible competition.
Cosimo Antonini +2 more
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CrystalsIn pursuit of unsymmetrical precursors for the novel series of anthracenyl-isoxazole amide (AIM) antitumor agents, a series of substituted anthracenes were subjected to bromination and re-aromatization in our study, during which we solved four single ...
Michael J. Campbell +4 more
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ISOXAZOLE–A POTENT PHARMACOPHORE [PDF]
, 2017 Isoxazole is an azole with an oxygen atom next to the nitrogen. Isoxazole rings are found in some natural products, such as ibotenic acid and also found in a number of drugs, including COX-2 inhibitor valdecoxib.
Chikkula, Krishna Veni, S., Raja
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Isoxazole-based pharmaceuticals.
, 2023 A series of new derivatives based on sulfamethoxazole were designed and synthesized in this study. The structures of the new compounds were confirmed based on a comprehensive characterization of spectral data by applied IR and 1H as well as 13C NMR ...
Vilma Petrikaitė (321635) +4 more
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An isoxazole approach to the coleophomones [PDF]
, 2007 Coleophomones, metabolites reported first in a Japanese patent in 1998 and then by Merck in 2000 from a Coleophoma fungus, have antifungal and antibacterial properties and inhibit bacterial cell-wall transglycosylase and human heart chymase. Their unique
Wing Hoi (Angella) Yuen (7166246) +1 more
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Orbital: The Electronic Journal of Chemistry, 2012 Using the concept of bioisosterismo, the new analogs isoxazole were designed from the molecular modification of grandisin and veraguensin neolignans, which have a grouping that is a furan ring bioisóstero isoxazole.
Ozildéia Soares +5 more
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Heterocyclic Communications, 2021 The present study aimed to design and synthesize a series of phenyl-isoxazole-carboxamide derivatives and investigate their antitumor and antioxidant activities. The in vitro cytotoxic evaluation was conducted using the MTS assay against four cancer cell
Hawash Mohammed +7 more
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Methyl 4-amino-3-methoxyisoxazole-5-carboxylate
IUCrData, 2023 The title compound, C6H8N2O4, a new derivative of isoxazole, has been synthesized and structurally characterized. The crystal structure shows the molecule to be almost planar (r.m.s.
Mohd Abdul Fatah Abdul Manan +2 more
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1-Methyl-3-(2-methylphenyl)-3,3a,4,9b-tetrahydro-1H-chromeno[4,3-c][1,2]oxazole-3a-carbonitrile
Acta Crystallographica Section E, 2011 In the title compound, C19H18N2O2, the five-membered isoxazole ring adopts an envelope conformation and the deviation of the N atom from the mean plane of the isoxazole ring is −0.3256 (11) Å.
K. Swaminathan +3 more
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Molecules, 2022 Isoxazole derivatives are significant enough due to their wide range of pharmacological and therapeutic activities. The purpose of the current study is to use computational, in vitro, in vivo, and extensive molecular approaches to examine the possible ...
Sidra Razzaq +7 more
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