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Two CuII complexes of 3,4,5-trimethyl-1H-pyrazole [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2018
The crystal structure of complexes of 3,4,5-trimethyl-1H-pyrazole with CuCl2·2H2O and Cu(NO3)2·2.5H2O are presented, namely di-μ-chlorido-bis[chloridobis(3,4,5-trimethyl-1H-pyrazole-κN2)copper(II)], [Cu2Cl4(C6H10N2)4] (1) and aquatetrakis(3,4,5-trimethyl-
Collin J. Vincent, Ian D. Giles, Jeffrey R. Deschamps   +2 more
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Current status of pyrazole and its biological activities

Journal of Pharmacy and Bioallied Sciences, 2016
Pyrazole are potent medicinal scaffolds and exhibit a full spectrum of biological activities. This review throws light on the detailed synthetic approaches which have been applied for the synthesis of pyrazole.
Mohd Javed Naim, Ozair Alam, Farah Nawaz, Md. Jahangir Alam, Perwaiz Alam   +4 more
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Crystal and molecular structure of 4-fluoro-1H-pyrazole at 150 K

Acta Crystallographica Section E: Crystallographic Communications, 2023
Only two 4-halo-1H-pyrazole crystal structures are known to date (chloro and bromo, the structure of 4-iodo-1H-pyrazole has not been reported yet). The triclinic structure of 4-fluoro-1H-pyrazole, C3H3FN2 (P\overline{1}), reported here is not isomorphous
Basil M. Ahmed, Matthias Zeller, Gellert Mezei   +2 more
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Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

Frontiers in Pharmacology, 2020
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo, Karlos Eduardo Pianoski, Mariellen Guilherme dos Santos, Danielle Lazarin-Bidóia, Hélito Volpato, Sidnei Moura, Celso Vataru Nakamura, Fernanda Andreia Rosa   +7 more
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PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer

Frontiers in Oncology, 2022
As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Minsung Kang, Navin Pandit, Ah-Young Kim, Suk Joon Cho, Young-Ju Kwon, Young-Ju Kwon, Jiyeon Ahn, Kyu Myung Lee, Sangwook Wu, Jeong Su Oh, Kwan-Young Jung, Kwan-Young Jung, Jae-Sung Kim, Jae-Sung Kim   +13 more
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An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

Beilstein Journal of Organic Chemistry, 2023
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma, Dharmender Singh, Sunit Kumar, Vaishali, Rahul Jamra, Naveen Banyal, Deepika, Chandi C. Malakar, Virender Singh   +8 more
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Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives

Molecules, 2022
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained ...
Diana Becerra, Rodrigo Abonia, Juan-Carlos Castillo   +2 more
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Antioxidant studies of 3-(5-(2,4-dichlorophenoxy)-3-methyl-1-phenyl-1Hpyrazole- 4-yl)-1-(furan-2-yl)prop-2-en-1-one

International Journal of Research in Pharmaceutical Sciences, 2021
Chalcones are flavonoid precursors, abundant in edible plants. The pyrazole moieties in chalcones show various pharmacological activities. Notably, Chalcone-based structures exhibit numerous pharmacological activities like antiinflammatory, antibacterial,
Ganesh Somashekarachar, Arpita Goswami, Kannika Byadarahalli Ravindranath, Madan Kumar Shankar, Manju Nagaraja   +4 more
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Crystal structure of 6-amino-4-(3-bromo-4-methoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile dimethyl sulfoxide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the pyrazole molecule of the title solvate, C15H13BrN4O2·C2H6OS, the dihedral angle between the benzene ring and the mean plane of the dihydropyrano[2,3-c]pyrazole ring system [r.m.s deviation = 0.031 (2) Å] is 86.71 (14)°.
Sammer Yousuf, Huma Bano, Munira Taj Muhammad, Khalid Mohammed Khan   +3 more
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Chiral versus achiral crystal structures of 4-benzyl-1H-pyrazole and its 3,5-diamino derivative

Acta Crystallographica Section E: Crystallographic Communications
The crystal structures of 4-benzyl-1H-pyrazole (C10H10N2, 1) and 3,5-diamino-4-benzyl-1H-pyrazole (C10H12N4, 2) were measured at 150 K. Although its different conformers and atropenantiomers easily interconvert in solution by annular tautomerism and/or ...
Emily R. Hayward, Matthias Zeller, Gellert Mezei   +2 more
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