Results 1 to 10 of about 19,339 (247)

Enantiomeric-Enriched Ferrocenes: Synthesis, Chiral Resolution, and Mathematic Evaluation of CD-chiral Selector Energies with Ferrocene-Conjugates

Molecules, 2017
Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH3 (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes.
Lubov V. Snegur, Yurii A. Borisov, Yuliya V. Kuzmenko, Vadim A. Davankov, Mikhail M. Ilyin, Mikhail M. Ilyin, Dmitry E. Arhipov, Alexander A. Korlyukov, Sergey S. Kiselev, Alexander A. Simenel   +9 more
doaj   +1 more source

Nano-ZnO Catalyzed Green and Efficient One-Pot Four-Component Synthesis of Pyranopyrazoles

Journal of Chemistry, 2013
An efficient zinc oxide nanoparticle catalyzed one-pot, four-component synthesis of 6-amino-3-methyl-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles from aromatic aldehyde, malononitrile, ethyl acetoacetate, and hydrazine hydrate in aqueous medium is ...
Sunil U. Tekale, Sushma S. Kauthale, Kavita M. Jadhav, Rajendra P. Pawar   +3 more
doaj   +1 more source

Pyrazoles as potential anti-angiogenesis agents: A contemporary overview

Frontiers in Chemistry, 2014
Angiogenesis is a mulit-step process by which new blood vessels are formed from preexisting vasculature. It is a key rate limiting factor in tumor growth since new blood vessels are necessary to increase tumor size. In this context it has been shown that
Konstantinos M Kasiotis, Evangelia N Tzanetou, Serkos A Haroutounian   +2 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives

Molecules, 2011
A novel series of 7,7-diphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 6a–h, were easily prepared via reactions of novel 2-hydrazinyl-4,4-diphenyl-1H-imidazol-5(4H)-one (2) with hydrazonoyl halides 3a–h.
Huwaida M.E. Hassaneen, Sobhi Mohamed Gomha   +1 more
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Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

Beilstein Journal of Organic Chemistry
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications.
Ignaz Betcke, Alissa C. Götzinger, Maryna M. Kornet, Thomas J. J. Müller   +3 more
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Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation

Archives of Pharmaceutical Sciences Ain Shams University, 2019
The antibiotic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is attributable to the expression of the high molecular mass transpeptidase enzyme, penicillin-binding protein 2a (PBP2a), an enzyme that catalyzes the cross-linking reaction
Menna-Allah W. Shalaby, Eman M.E. Dokla, Rabah A. T. Serya, Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Synthesis and Characterization of New Pyrano[2,3-c]pyrazole Derivatives as 3-Hydroxyflavone Analogues

Molecules, 2023
In this paper, an efficient synthetic route from pyrazole-chalcones to novel 6-aryl-5-hydroxy-2-phenylpyrano[2,3-c]pyrazol-4(2H)-ones as 3-hydroxyflavone analogues is described.
Arminas Urbonavičius, Sonata Krikštolaitytė, Aurimas Bieliauskas, Vytas Martynaitis, Joana Solovjova, Asta Žukauskaitė, Eglė Arbačiauskienė, Algirdas Šačkus   +7 more
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Synthesis, in vitro antioxidant evaluation, and in silico COX inhibitory activity of 3-(R2 = methyl, phenyl)-1H-[1]benzopyran[4,3-c]pyrazol-4-one derivatives

Results in Chemistry
Pyrazole functionality is widely observed in various biologically active compounds, and its fusion with a coumarin moiety renders a type of molecule known as coumarin-pyrazoles.
Villa- Martínez Cesar Alonso, Magaña-Vergara Nancy Evelyn, Barragán-Mendoza Lina, Madrigal-Angulo José Luis, Ramos-Organillo Ángel Andres, Padilla-Martínez Itzia Irene, Hernández-Fuentes Gustavo Alejandro, Razo-Hernández Rodrigo Said, David J. Pérez, Martínez-Martínez Francisco Javier   +9 more
doaj   +1 more source

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction

Beilstein Journal of Organic Chemistry, 2019
Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and functional ...
Vaida Milišiūnaitė, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, Wolfgang Holzer, Algirdas Šačkus   +5 more
doaj   +1 more source

An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks

SynOpen, 2017
An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation­ of the corresponding pyrazolylacetonitriles is developed.
Pavel S. Nosik, Oleksiy S. Artamonov, Sergey V. Ryabukhin, Oleksandr O. Grygorenko   +3 more
doaj   +1 more source