Results 1 to 10 of about 18,189 (198)
Natural and Biomimetic Antitumor Pyrazoles, A Perspective [PDF]
Molecules, 2020 The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs.
Ana Carreira +2 more
exaly +4 more sources
Enantioselective Addition of Pyrazoles to Dienes** [PDF]
Angewandte Chemie International Edition, 2021 Abstract We report the first enantioselective addition of pyrazoles to 1,3‐dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd 0 ‐catalyzed ...
Alexander Y. Jiu +4 more
core +9 more sources
Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates [PDF]
Organics, 2022 N-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted ...
Rowan I. L. Meador +2 more
doaj +2 more sources
Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities [PDF]
Molecules, 2021 Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives ...
Mohamed Ramadan +4 more
doaj +5 more sources
Regio- and Stereoselective Switchable Synthesis of (E)- and (Z)-N-Carbonylvinylated Pyrazoles [PDF]
Molecules, 2023 Regio- and stereoselective switchable synthesis of (E)- and (Z)-N-carbonylvinylated pyrazoles is first developed by using the Michael addition reaction of pyrazoles and conjugated carbonyl alkynes.
Xue Zhang +3 more
doaj +2 more sources
Nickel-Catalyzed, One-Pot Synthesis of Pyrazoles [PDF]
Chemistry Proceedings, 2022 Recently, multi-component, one-pot reactions have been shown to be efficient and environmentally friendly methods compared to traditional, linear-step syntheses.
Nassima Medjahed +4 more
doaj +2 more sources
SUBSTITUTED 4-NITROSOPYRAZOLES IN THE DIELS-ALDER REACTION
Siberian Journal of Life Sciences and Agriculture, 2021 Background. 4-Nitrosopyrazoles have become widespread in the pharmaceutical industry and in chemistry due to their high reactivity and biological activity. However, the interaction of 3,5-substituted 4-nitroso-1H-pyrazoles with diene hydrocarbons has not
Darya S. Volkova +4 more
doaj +1 more source
Molbank, 2022 Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, and antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties.
Linh Lam, Sang H. Park, Joseph Sloop
doaj +1 more source
Preparation of novel acyl pyrazoles and triazoles by means of oxidative functionalization reactions
Heterocyclic Communications, 2023 Novel acyl pyrazoles and acyl triazoles have been prepared by means of the oxidative amidation of aldehydes in the presence of the requisite azole. Yields range from modest to good in both cases, and some limitations of the substrate scope have been ...
Wadey Geoffrey P. +3 more
doaj +1 more source
Carbamidine-substituted Pyrazoles [PDF]
Nature, 1951 THE ease with which 1-substituted pyrazoles may be converted into the free imino compounds varies with the nature of the 1-substituent and the reacting substance. Thus, 1,3,5-trimethyl pyrazole may be nitrated1 and 1-phenyl pyrazole reduced to the pyrazoline2 without loss of the N-methyl or N-phenyl groups respectively.
F L, SCOTT, C M B, MURPHY, J, REILLY
openaire +2 more sources