Results 1 to 10 of about 37,807 (249)
Natural and Biomimetic Antitumor Pyrazoles, A Perspective
Molecules, 2020 The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs.
Braga Susana Santos +2 more
exaly +5 more sources
Enantioselective Addition of Pyrazoles to Dienes [PDF]
Angewandte Chemie International Edition, 2021 We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity.
Alexander Y., Jiu +4 more
core +8 more sources
Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities
Molecules, 2021 Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives ...
Mohamed Ramadan +4 more
doaj +5 more sources
Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents [PDF]
Beilstein Journal of Organic Chemistry, 2017 A synthesis of tetrasubstituted pyrazoles containing two, three or four pyridinyl substituents is described. Hence, the reaction of 1,3-dipyridinyl-1,3-propanediones with 2-hydrazinopyridine or phenylhydrazine, respectively, affords the corresponding 1,3,
Josef Jansa +6 more
doaj +6 more sources
Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates
Organics, 2022 N-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted ...
Rowan I. L. Meador +2 more
doaj +2 more sources
Regio- and Stereoselective Switchable Synthesis of (E)- and (Z)-N-Carbonylvinylated Pyrazoles
Molecules, 2023 Regio- and stereoselective switchable synthesis of (E)- and (Z)-N-carbonylvinylated pyrazoles is first developed by using the Michael addition reaction of pyrazoles and conjugated carbonyl alkynes.
Xue Zhang +3 more
doaj +2 more sources
Molecules, 2018 Synthesis of novel pyrazole-fused heterocycles, i.e., dihydro-1H- or 2H-oxepino[3,2-c]pyrazoles (6 or 7) from 4-allyloxy-1H-pyrazoles (1) via combination of Claisen rearrangement and ring-closing metathesis (RCM) has been achieved.
Yoshihide Usami +3 more
doaj +2 more sources
New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
Molecules, 2021 (1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT and p38MAPK phosphorylation in different manners and with different potency; (2) Methods:
Maria Grazia Signorello +5 more
doaj +2 more sources
Magnetic Resonance in Chemistry, 1993 The carbon-13 chemical shifts and coupling constants of 1168 pyrazoles are reported, some of them in several solvents. These data are briefly discussed on the basis of statistical treatment and qualitative comparisons.Peer ...
Mikael Begtrup +2 more
exaly +3 more sources
Nickel-Catalyzed, One-Pot Synthesis of Pyrazoles
Chemistry Proceedings, 2022 Recently, multi-component, one-pot reactions have been shown to be efficient and environmentally friendly methods compared to traditional, linear-step syntheses.
Nassima Medjahed +4 more
doaj +2 more sources