Results 31 to 40 of about 37,807 (249)

Design and synthesis of pyrazole derivatives for in vitro screening to protect angiotensin-converting enzyme 2 human cells against COVID-19

Current Medicine Research and Practice, 2021
Background: ACE2 is a receptor for Corona virus. COVID-19 (coronavirus) is a deadly virus which can enter the human body through 'angiotensin-converting enzyme 2' human cells, hardly damages the respiratory system. On severe infection on these cells make
Ganesh N Yallappa, S Rajendra Prasad, Gayatri Vaidya   +2 more
doaj   +1 more source

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Bulletin of the Chemical Society of Ethiopia, 2014
Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%.
K. Ranganathan, R. Suresh, G. Vanangamudi, K. Thirumurthy, P. Mayavel, G. Thirunarayanan   +5 more
doaj   +1 more source

Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles

, 2021
Pyrazoles are ubiquitous structures in medicinal chemistry. We report the first regioselective route to C3-hydroxyarylated pyrazoles obtained through reaction of pyrazole N-oxides with arynes using mild conditions.
Darren J. Derksen, Jeffrey F. Van Humbeck, Evgueni Gorobets (2741056), Darren J. Derksen (2297485), Leonie O’Sullivan, Benjamin S. Gelfand (1578766), Leonie O’Sullivan (11836729), Duncan K. Brownsey, Evgueni Gorobets, Jeffrey F. Van Humbeck (11836735), Ketul V. Patel (3423740), Duncan K. Brownsey (11836732), Ben C. Rowley (4818576), Benjamin S. Gelfand, Ketul V. Patel, Ben C. Rowley   +15 more
core   +1 more source

Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F₁F_O-ATPase and Mitochondrial Permeability Transition Pore Formation

Pharmaceutics, 2023
An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity ...
Vincenzo Algieri, Cristina Algieri, Paola Costanzo, Giulia Fiorani, Antonio Jiritano, Fabrizio Olivito, Matteo Antonio Tallarida, Fabiana Trombetti, Loredana Maiuolo, Antonio De Nino, Salvatore Nesci   +10 more
doaj   +1 more source

Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters

Angewandte Chemie, EarlyView.
A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter, Cameron J. MacRae, Haoran Xiong, Daniel Rozsar, Katherine F. P. Clarke, Darren J. Dixon   +5 more
wiley   +2 more sources

Synthesis of pyrazole and pyrazole amidocobaloximes

, 2004
Department of Chemistry, Osmania University, Hyderabad-500 007, India E-mail : ssnsirasani @yahoo.com Manuscript received 23 September 2002, revised 23 April 2003. accepted 11 July 2003 A series of cyano (ligand) cobaloximes have been prepared where, the ligand is pyrazole (Pz), 1-(acetamido)pyrazole (Apz), 1-(N-methylacetamido)pyrazole (MAPz), 1 ...
A. Rajeshwar Rao, G. Gopinath, J. V. Madhuri, S. Satyanarayana   +3 more
openaire   +1 more source

Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes

Beilstein Journal of Organic Chemistry, 2011
An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-
Yiwen Yang, Chunxiang Kuang, Hui Jin, Qing Yang, Zhongkui Zhang   +4 more
doaj   +1 more source

Order versus disorder in two isomorphous pyrazolone-substituted diethyl propanedioates prepared using a three-component one-pot reaction under solvent-free conditions

Acta Crystallographica Section E: Crystallographic Communications, 2020
Two new substituted propanedioate esters have been synthesized using a three-component solvent-free thermal reaction between diethyl propanedioate (diethyl malonate), 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and an aryl azide, forming two ...
Tharangini K. Shreekanth, Hemmige S. Yathirajan, Balakrishna Kalluraya, Sabine Foro, Christopher Glidewell   +4 more
doaj   +1 more source

Rhodium(III)-Catalyzed Oxidative Coupling of 5-Aryl-1H-pyrazoles with Alkynes and Acrylates

, 2011
Rhodium(III)-Catalyzed Oxidative Coupling of 5-Aryl-1H-pyrazoles with Alkynes and Acrylates[RhCp*Cl(2)](2)-catalyzed oxidative coupling of 5-aryl-1H-pyrazoles with alkynes and acrylates has been achieved using Cu(OAc)(2) as an oxidant.
李兴伟, Zhao, Miao, Li, Xingwei
core   +1 more source

Enantiomeric-Enriched Ferrocenes: Synthesis, Chiral Resolution, and Mathematic Evaluation of CD-chiral Selector Energies with Ferrocene-Conjugates

Molecules, 2017
Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH3 (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes.
Lubov V. Snegur, Yurii A. Borisov, Yuliya V. Kuzmenko, Vadim A. Davankov, Mikhail M. Ilyin, Mikhail M. Ilyin, Dmitry E. Arhipov, Alexander A. Korlyukov, Sergey S. Kiselev, Alexander A. Simenel   +9 more
doaj   +1 more source