Results 31 to 40 of about 18,189 (198)

Pyrazoles as potential anti-angiogenesis agents: A contemporary overview

Frontiers in Chemistry, 2014
Angiogenesis is a mulit-step process by which new blood vessels are formed from preexisting vasculature. It is a key rate limiting factor in tumor growth since new blood vessels are necessary to increase tumor size. In this context it has been shown that
Konstantinos M Kasiotis, Evangelia N Tzanetou, Serkos A Haroutounian   +2 more
doaj   +1 more source

‐Substituted Pyrazoles [PDF]

, 2020
An efficient one-pot, two step method for fusing two biologically active motifs, CF3-substituted pyrazoles and isochromenes, was developed. Selective O-benzylation of CF3-substituted pyrazolones and subsequent Pd-catalyzed direct C–H arylation generate a
Života Selaković, Selaković, Života, Igor M. Opsenica, Wipf, Peter, Filip Živković, Opsenica, Igor, Andrea M. Nikolić, Peter Wipf, Živković, Filip, Nikolić, Andrea   +9 more
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Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives

Molecules, 2011
A novel series of 7,7-diphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 6a–h, were easily prepared via reactions of novel 2-hydrazinyl-4,4-diphenyl-1H-imidazol-5(4H)-one (2) with hydrazonoyl halides 3a–h.
Huwaida M.E. Hassaneen, Sobhi Mohamed Gomha   +1 more
doaj   +1 more source

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents

Molecules, 2021
The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities.
Martha Mantzanidou, Eleni Pontiki, Dimitra Hadjipavlou-Litina   +2 more
doaj   +1 more source

Regioselective Synthesis of Multisubstituted Pyrazoles via Cyclocondensation of β-Thioalkyl-α,β-Unsaturated Ketones with Hydrazines [PDF]

, 2011
Regioselective Synthesis of Multisubstituted Pyrazoles via Cyclocondensation of β-Thioalkyl-α,β-Unsaturated Ketones with ...
于海丰, 金伟伟, 余正坤
core  

Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation

Archives of Pharmaceutical Sciences Ain Shams University, 2019
The antibiotic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is attributable to the expression of the high molecular mass transpeptidase enzyme, penicillin-binding protein 2a (PBP2a), an enzyme that catalyzes the cross-linking reaction
Menna-Allah W. Shalaby, Eman M.E. Dokla, Rabah A. T. Serya, Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Synthesis and Characterization of New Pyrano[2,3-c]pyrazole Derivatives as 3-Hydroxyflavone Analogues

Molecules, 2023
In this paper, an efficient synthetic route from pyrazole-chalcones to novel 6-aryl-5-hydroxy-2-phenylpyrano[2,3-c]pyrazol-4(2H)-ones as 3-hydroxyflavone analogues is described.
Arminas Urbonavičius, Sonata Krikštolaitytė, Aurimas Bieliauskas, Vytas Martynaitis, Joana Solovjova, Asta Žukauskaitė, Eglė Arbačiauskienė, Algirdas Šačkus   +7 more
doaj   +1 more source

Rh(III) catalyzed oxidative synthesis of pyrazoles from azomethines and acrylamides [PDF]

, 2013
Rh(III) catalyzed oxidative synthesis of pyrazoles from azomethines and ...
李兴伟, 甄文翠, 杜正银
core  

Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

Beilstein Journal of Organic Chemistry
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications.
Ignaz Betcke, Alissa C. Götzinger, Maryna M. Kornet, Thomas J. J. Müller   +3 more
doaj   +1 more source

Catalyst-Free One-Pot Access to Pyrazoles and Disulfide-Tethered Pyrazoles via Deamidative Heteroannulation of beta-Ketodithioesters with Semicarbazide Hydrochloride in Water [PDF]

, 2018
An operationally simple, mild, and catalyst-free one-pot protocol to access privileged pyrazoles and disulfide-tethered pyrazoles has been devised by 3+2] heteroannulation of beta-ketodithioesters with semicarbazide hydrochloride in water under open air.
Koley, Suvajit, Soni, Sonam, Panja, Sumit Kumar, Singh, Maya Shankar   +3 more
core   +1 more source