Results 51 to 60 of about 24,009 (260)

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, EarlyView.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

Beilstein Journal of Organic Chemistry
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications.
Ignaz Betcke, Alissa C. Götzinger, Maryna M. Kornet, Thomas J. J. Müller   +3 more
doaj   +1 more source

Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation

Archives of Pharmaceutical Sciences Ain Shams University, 2019
The antibiotic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is attributable to the expression of the high molecular mass transpeptidase enzyme, penicillin-binding protein 2a (PBP2a), an enzyme that catalyzes the cross-linking reaction
Menna-Allah W. Shalaby, Eman M.E. Dokla, Rabah A. T. Serya, Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Synthesis and Characterization of New Pyrano[2,3-c]pyrazole Derivatives as 3-Hydroxyflavone Analogues

Molecules, 2023
In this paper, an efficient synthetic route from pyrazole-chalcones to novel 6-aryl-5-hydroxy-2-phenylpyrano[2,3-c]pyrazol-4(2H)-ones as 3-hydroxyflavone analogues is described.
Arminas Urbonavičius, Sonata Krikštolaitytė, Aurimas Bieliauskas, Vytas Martynaitis, Joana Solovjova, Asta Žukauskaitė, Eglė Arbačiauskienė, Algirdas Šačkus   +7 more
doaj   +1 more source

Synthesis of novel heteroleptic delocalised cationic pyrazole gold complexes as potent HepG2 cytotoxic agents [PDF]

, 2018
A new series of cationic gold(I) pyrazole complexes were prepared in excellent yields as their perchlorate salts. Results of cell viability assays show that these novel complexes have good cytotoxic properties against the human HepG2 cancer cell line ...
Afolabi, Fatai, Crickmore, Neil, Lemaitre, Clement, Rivière, Guillaume, Roe, Mark, Souissi, Wided, Viseux, Eddy   +6 more
core   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

N\u3csup\u3e1\u3c/sup\u3e-Acetyl-3\u27-methylandrosta-4,16-dieno[16,17-\u3cem\u3ed\u3c/em\u3e]pyrazole-3-one [PDF]

, 1994
In an attempt to find the structural features promoting the thermal isomerization of the N-acylated steroid [16,17-d]pyrazoles into [17,16-c]pyrazole derivatives,the X-ray structure analysis of the title compound, C23H30N2O3, (1), has been carried out ...
Kamernitzky, Alexey V., Lindeman, Sergey V., Nava, Ezequiel Huipe, Skorova, Alina V., Vesela, Irina V., Yanovsky, Alexandr I.   +5 more
core   +1 more source

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. [PDF]

, 2015
A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated ...
Browne, Duncan L, Ley, Steven V, Poh, Jian-Siang   +2 more
core   +5 more sources

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction

Beilstein Journal of Organic Chemistry, 2019
Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and functional ...
Vaida Milišiūnaitė, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, Wolfgang Holzer, Algirdas Šačkus   +5 more
doaj   +1 more source

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Molecules, 2022
Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the
Vera L. M. Silva, Artur M. S. Silva
doaj   +1 more source