Results 61 to 70 of about 24,009 (260)

Temperature-Controlled Divergent Synthesis of Pyrazoles and 1-Tosyl-1H-pyrazoles under Transition-Metal-Catalyst- and Oxidant-Free Conditions

Molecules
Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed.
Kai Wang, Wenjing Xu, Chengcai Xia, Xianting Cao   +3 more
doaj   +1 more source

An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks

SynOpen, 2017
An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation­ of the corresponding pyrazolylacetonitriles is developed.
Pavel S. Nosik, Oleksiy S. Artamonov, Sergey V. Ryabukhin, Oleksandr O. Grygorenko   +3 more
doaj   +1 more source

Synthesis of pyrazole and pyrazole amidocobaloximes

, 2004
Department of Chemistry, Osmania University, Hyderabad-500 007, India E-mail : ssnsirasani @yahoo.com Manuscript received 23 September 2002, revised 23 April 2003. accepted 11 July 2003 A series of cyano (ligand) cobaloximes have been prepared where, the ligand is pyrazole (Pz), 1-(acetamido)pyrazole (Apz), 1-(N-methylacetamido)pyrazole (MAPz), 1 ...
A. Rajeshwar Rao, G. Gopinath, J. V. Madhuri, S. Satyanarayana   +3 more
openaire   +1 more source

The pyrazolo[4,3-c]pyrazole core as a novel and versatile scaffold for developing dual DYRK1A-CLK1 inhibitors targeting key processes of Alzheimer's disease pathology

European Journal of Medicinal Chemistry Reports
In the current study, we designed, synthesized, and characterized a series of substituted pyrazolo[4,3-c]pyrazoles. These novel compounds were evaluated in vitro for their inhibitory activity over a panel of protein kinases to determine their potential ...
Vaia-Argyro Bakalakou, Barbara Mavroidi, Amalia D. Kalampaliki, Béatrice Josselin, Stéphane Bach, Alexios-Leandros Skaltsounis, Panagiotis Marakos, Nicole Pouli, Maria Pelecanou, Vassilios Myrianthopoulos, Sandrine Ruchaud, Ioannis K. Kostakis   +11 more
doaj   +1 more source

An Example of Polynomial Expansion: The Reaction of 3(5)-Methyl-1H-Pyrazole with Chloroform and Characterization of the Four Isomers

Molecules, 2019
The reaction in phase-transfer catalyzed conditions of 3(5)-methyl-1H-pyrazole with chloroform affords four isomers 333, 335, 355 and 555 in proportions corresponding to the polynomial expansion (a + b)3, with a = 0.6 and b = 0.4, a and b being 3-methyl ...
Vera L. M. Silva, Artur M. S. Silva, Rosa M. Claramunt, Dionisia Sanz, Lourdes Infantes, Ángela Martínez-López, Felipe Reviriego, Ibon Alkorta, José Elguero   +8 more
doaj   +1 more source

Synthesis of enantioenriched azo compounds: Organocatalytic Michael addition of formaldehyde N-tert-butyl hydrazone to nitroalkenes [PDF]

, 2013
The unprecedented diaza-ene reaction of formaldehyde N-tert-butyl hydrazone with nitroalkenes can be efficiently catalyzed by an axially chiral bis-thiourea to afford the corresponding diazenes in good to excellent yields (60-96%) and moderate ...
Bernal Fernández, Pablo, Daza Sánchez, Silvia, Fernández Fernández, Rosario Fátima, Lassaletta Simón, José María, Monge Fernández, David   +4 more
core   +1 more source

Chelate-modified polymers for atmospheric gas chromatography [PDF]

, 1980
Chromatographic materials were developed to serve as the stationary phase of columns used in the separation of atmospheric gases. These materials consist of a crosslinked porous polymer matrix, e.g., a divinylbenzene polymer, into which has been embedded
Christensen, W. W., Mayer, L. A., Woeller, F. H.   +2 more
core   +1 more source

Synthesis of 4-functionalized pyrazoles via oxidative thio- or selenocyanation mediated by PhICl2 and NH4SCN/KSeCN

Beilstein Journal of Organic Chemistry
A series of 4-thio/seleno-cyanated pyrazoles was conveniently synthesized from 4-unsubstituted pyrazoles using NH4SCN/KSeCN as thio/selenocyanogen sources and PhICl2 as the hypervalent iodine oxidant.
Jialiang Wu, Haofeng Shi, Xuemin Li, Jiaxin He, Chen Zhang, Fengxia Sun, Yunfei Du   +6 more
doaj   +1 more source

Metal Acetylides in Cycloaddition Reactions [PDF]

, 2017
This review highlights recent advances in the synthesis of (hetero)aromatic systems via cycloaddition reactions of alkynylmetals with dienes and dipoles.
Comas-Barceló, J., Harrity, J.P.A.
core   +1 more source

Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity

Molecules, 2019
To find novel antitumor agents, a series of 1H-benzofuro[3,2-c]pyrazole derivatives 4a-e were designed and synthesized. The treatment of 6-methoxybenzofuran-3(2H)-one 3 with LiHMDS in anhydrous tetrahydrofuran (THF) followed by reaction with 3-substitued
Ying-Jie Cui, Long-Qian Tang, Cheng-Mei Zhang, Zhao-Peng Liu   +3 more
doaj   +1 more source