Results 61 to 70 of about 53,373 (308)

Regioselective Synthesis of 1-Aryl-3,4-substituted/annulated-5-(methylthio)pyrazoles and 1-Aryl-3-(methylthio)-4,5-substituted/annulated Pyrazoles^§

, 2016
Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio)pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene ...
S. Peruncheralathan (2505490), H. Ila (1643089), T. A. Khan (2662342), H. Junjappa (2358067)   +3 more
core   +1 more source

Über die Bindungsstelle hinausgedacht: Ein sich selbsteinkapselnder Kinase‐Inhibitor modelliert seine Bindetasche und erzielt so Selektivität

Angewandte Chemie, EarlyView.
Um außergewöhnlich wirksame Wirkstoffe zu entwickeln, ist es erforderlich, über die Bindungsstelle hinaus zu denken. Diese Arbeit zeigt, dass die auf den ersten Blick kontraintuitive Adressierung einer konservierten Region der Kinase zu einer hochselektiven Bindung führen kann.
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

Beilstein Journal of Organic Chemistry
Pyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications.
Ignaz Betcke, Alissa C. Götzinger, Maryna M. Kornet, Thomas J. J. Müller   +3 more
doaj   +1 more source

Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluation

Archives of Pharmaceutical Sciences Ain Shams University, 2019
The antibiotic resistance of methicillin-resistant Staphylococcus aureus (MRSA) is attributable to the expression of the high molecular mass transpeptidase enzyme, penicillin-binding protein 2a (PBP2a), an enzyme that catalyzes the cross-linking reaction
Menna-Allah W. Shalaby, Eman M.E. Dokla, Rabah A. T. Serya, Khaled A. M. Abouzid   +3 more
doaj   +1 more source

Synthesis and Characterization of New Pyrano[2,3-c]pyrazole Derivatives as 3-Hydroxyflavone Analogues

Molecules, 2023
In this paper, an efficient synthetic route from pyrazole-chalcones to novel 6-aryl-5-hydroxy-2-phenylpyrano[2,3-c]pyrazol-4(2H)-ones as 3-hydroxyflavone analogues is described.
Arminas Urbonavičius, Sonata Krikštolaitytė, Aurimas Bieliauskas, Vytas Martynaitis, Joana Solovjova, Asta Žukauskaitė, Eglė Arbačiauskienė, Algirdas Šačkus   +7 more
doaj   +1 more source

Regioselective synthesis of 1,3,5- and 1,3,4,5-substituted pyrazoles via acylation of N-Boc-N-substituted hydrazones

, 2011
Acylation of N-Boc-N-methylhydrazones followed by TFA treatment affords regioselective access to substituted pyrazoles. Both regioisomers of 1-methyl-3,5-disubstituted-1H-pyrazoles can be selectively obtained.
Daniele Andreotti, ROSINI, GOFFREDO, RIGHI, PAOLO, Paolo Righi, R. Profeta, D. Andreotti, S. Spada, Roberto Profeta, Simone Spada, TINARELLI, ALESSANDRO, Alessandro Tinarelli, Goffredo Rosini   +11 more
core   +1 more source

Synthesis of some new 1,3,5-trisubstituted pyrazoles as antioxidant and antiinflammatory agents [PDF]

, 2019
A series of some new 1,3,5-trisubstituted pyrazoles was synthesized by the reaction of α-β dibromochalcones with phenylhydrazine hydrochloride.
Singh, Jitender, Dua, Jagdeep, Arora, Pragi   +2 more
core   +1 more source

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction

Beilstein Journal of Organic Chemistry, 2019
Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and functional ...
Vaida Milišiūnaitė, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, Wolfgang Holzer, Algirdas Šačkus   +5 more
doaj   +1 more source

An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks

SynOpen, 2017
An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation­ of the corresponding pyrazolylacetonitriles is developed.
Pavel S. Nosik, Oleksiy S. Artamonov, Sergey V. Ryabukhin, Oleksandr O. Grygorenko   +3 more
doaj   +1 more source

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Molecules, 2022
Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the
Vera L. M. Silva, Artur M. S. Silva
doaj   +1 more source