Results 41 to 50 of about 18,189 (198)
Beilstein Journal of Organic Chemistry, 2019 Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and functional ...
Vaida Milišiūnaitė +5 more
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An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks
SynOpen, 2017 An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation of the corresponding pyrazolylacetonitriles is developed.
Pavel S. Nosik +3 more
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Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity
Molecules, 2022 Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the
Vera L. M. Silva, Artur M. S. Silva
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Synthesis of ferrocenyl substituted pyrazoles [PDF]
, 2005 Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess.
MERAL GÖRMEN
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European Journal of Medicinal Chemistry ReportsIn the current study, we designed, synthesized, and characterized a series of substituted pyrazolo[4,3-c]pyrazoles. These novel compounds were evaluated in vitro for their inhibitory activity over a panel of protein kinases to determine their potential ...
Vaia-Argyro Bakalakou +11 more
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Molecules, 2019 The reaction in phase-transfer catalyzed conditions of 3(5)-methyl-1H-pyrazole with chloroform affords four isomers 333, 335, 355 and 555 in proportions corresponding to the polynomial expansion (a + b)3, with a = 0.6 and b = 0.4, a and b being 3-methyl ...
Vera L. M. Silva +8 more
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Regioselective Synthesis of 1-Aryl-3,4-substituted/annulated-5-(methylthio)pyrazoles and 1-Aryl-3-(methylthio)-4,5-substituted/annulated Pyrazoles§ [PDF]
, 2016 Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio)pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene ...
S. Peruncheralathan (2505490) +3 more
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MoleculesHerein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed.
Kai Wang +3 more
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Catalytic C–H Allylation and Benzylation of Pyrazoles [PDF]
, 2016 We describe a general approach for the synthesis of allylated and benzylated pyrazoles. An electron-withdrawing substituent, such as nitro, chloro, and ester groups, at C4 renders the Lewis basic nitrogen atom to be less basic and the C–H bond more ...
Ha-Lim Jang (1695910) +3 more
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