Results 21 to 30 of about 53,373 (308)
Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2018 An efficient, one-pot and metal-free process for the preparation of 3,5-disubstituted and 3,4,5-trisubstituted pyrazoles on multi-gram scale was developed.
V. Lellek +5 more
semanticscholar +2 more sources
Amino-Pyrazoles in Medicinal Chemistry: A Review
International Journal of Molecular Sciences, 2023 A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential. Consequently, the search for new pyrazole-based compounds is of great interest to the academic community as well as industry.
Matteo Lusardi +2 more
semanticscholar +1 more source
Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion
Journal of the American Chemical Society, 2022 A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has been achieved guided by computational analysis. The pyrimidine heterocycle is the most common diazine in FDA-approved drugs, and pyrazoles are the most common ...
G. L. Bartholomew +2 more
semanticscholar +1 more source
Copper-Catalyzed Hydroamination: Enantioselective Addition of Pyrazoles to Cyclopropenes
Journal of the American Chemical Society, 2023 Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo-, and enantiocontrol. The observed N2:N1 regioselectivity favors the more
Ming-Hao Wang +5 more
semanticscholar +1 more source
Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates
Organics, 2022 N-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted ...
Rowan I. L. Meador +2 more
doaj +1 more source
Journal of Molecular Structure, 2022 The discovery and development of new potent antimicrobial and antioxidant agents is an essential lever to protect living beings against pathogenic microorganisms and free radicals.
Mohammed Chalkha +11 more
semanticscholar +1 more source
Recent Advances in Synthesis and Properties of Pyrazoles
Chemistry, 2022 Pyrazole-containing compounds represent one of the most influential families of N-heterocycles due to their proven applicability and versatility as synthetic intermediates in preparing relevant chemicals in biological, physical-chemical, material science,
María-Camila Ríos, J. Portilla
semanticscholar +1 more source
Antibacterial pyrazoles: tackling resistant bacteria.
Future Medicinal Chemistry, 2022 Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel ...
M. A. Alam
semanticscholar +1 more source
ACS Omega, 2021 An efficient taurine-catalyzed green multicomponent approach has been described for the first time to synthesize densely substituted therapeutic core dihydropyrano[2,3-c]pyrazoles.
Ghanshyam Mali +6 more
semanticscholar +1 more source
Pyrene-linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights. [PDF]
Smart MolA series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Kasundra DV, Patel PN.
europepmc +2 more sources