Results 21 to 30 of about 24,009 (260)

The structure of the agrochemical fungicidal 4-Chloro-3-(3,5-dichloropheny)-1H-pyrazole, RPA 406194 and related compounds [PDF]

, 2003
The difficulties to obtain convenient monocrystals of the important fungicide RPA 406194 have been overcome by a combination of solid state 13C NMR, X-ray powder diffraction and molecular modeling.
Abboud, Aguilar-Parrilla, Bennema, Berkovitch-Yellin, Burton, Cativiela, Cativiela, Claramunt, Dunitz, Elguero, Elguero, Eliel, Foces-Foces, Grimbergen, Harris, Hartman, Hartman, Hartman, Hartman, Jean Paul Canselier, Jean-Pierre Vors, José Elguero, Lin, Lin, Lommerse, López, Marı́a Luisa Jimeno, Minkin, Nadine Gabas, Nadine Jagerovic, Olivieri, Stothers, Vincent Gerbaud, Weissbuch, Winn, Winn   +35 more
core   +3 more sources

Synthesis of Dihydrooxepino[3,2-c]Pyrazoles via Claisen Rearrangement and Ring-Closing Metathesis from 4-Allyloxy-1H-pyrazoles

Molecules, 2018
Synthesis of novel pyrazole-fused heterocycles, i.e., dihydro-1H- or 2H-oxepino[3,2-c]pyrazoles (6 or 7) from 4-allyloxy-1H-pyrazoles (1) via combination of Claisen rearrangement and ring-closing metathesis (RCM) has been achieved.
Yoshihide Usami, Aoi Kohno, Hiroki Yoneyama, Shinya Harusawa   +3 more
doaj   +1 more source

3-(3-Chloroanilino)-1-(3,5-dimethyl-1Hpyrazol-1-yl)propan-1-one [PDF]

, 2009
In the molecule of the title compound, C14H16ClN3O, the benzene and pyrazole rings are oriented at a dihedral angle of 3.50 (3)°. In the crystal structure, intermolecular N-H...O hydrogen bonds link the molecules into chains.
Aamer Saeed, Shahid Hussain, Michael Bolte, Akarca, Allen, Blessing, Elguero, Eriksson, Escolar, Mella, Penning, Saeed, Sheldrick, Spek   +13 more
core   +1 more source

Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]

, 2019
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam, Alina Secrieru, Alkorta, Andes, Anwar, Behr, Brown, Castillo, Catalan, Chauhan, Clark, Elguero, Elnagdi, Favre, Fichez, Hall, Horta, Katritzky, Katritzky, Kost, Kumar, Larina, Maria Lurdes Santos Cristiano, Mert, Minkin, Minkin, Mohamed, Nagy, Nimbalkar, Paul Michael O’Neill, Schofield, Simons, Szajda, Taylor, Zerbi   +34 more
core   +2 more sources

SOCl2 catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent 1H pyrazoles

Bulletin of the Chemical Society of Ethiopia, 2014
Some aryl-aryl 1H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl2. The yields of the pyrazoles are more than 85%.
K. Ranganathan, R. Suresh, G. Vanangamudi, K. Thirumurthy, P. Mayavel, G. Thirunarayanan   +5 more
doaj   +1 more source

Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F₁F_O-ATPase and Mitochondrial Permeability Transition Pore Formation

Pharmaceutics, 2023
An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity ...
Vincenzo Algieri, Cristina Algieri, Paola Costanzo, Giulia Fiorani, Antonio Jiritano, Fabrizio Olivito, Matteo Antonio Tallarida, Fabiana Trombetti, Loredana Maiuolo, Antonio De Nino, Salvatore Nesci   +10 more
doaj   +1 more source

Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. [PDF]

, 2015
Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions.
Houk, KN, Liang, Yong, Murphy, Jennifer M, Narayanam, Maruthi Kumar   +3 more
core   +1 more source

Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. [PDF]

, 2016
The combretastatins are an important class of tubulin-binding agents. Of this family, a number of compounds are potent tumor Vascular Disrupting Agents (VDAs) and have shown promise in the clinic for cancer therapy.
Brown, A.W., Fisher, M., Harrity, J.P., Kanthou, C., Tozer, G.M.   +4 more
core   +2 more sources

Efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles from 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes

Beilstein Journal of Organic Chemistry, 2011
An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-
Yiwen Yang, Chunxiang Kuang, Hui Jin, Qing Yang, Zhongkui Zhang   +4 more
doaj   +1 more source

Study of synthesis of 2-(2-alkoxyphenyl)-1H-imidazoles. Comparison of oxidative aromatization reactions of imidazolines [PDF]

, 2006
The reaction of methyl salicylate with ethane-1,2-diamine has been used to prepare 2-(2-hydroxyphenyl)-1H-imidazoline. This compound was alkylated with alkyl halides to give five new 2-(2-alkoxyphenyl)-1H-imidazolines (alkyl = propyl, isopropyl, isobutyl,
Handlíř, Karel, Lišková, Vlasta, Ludwig, Miroslav, Pařík, Patrik, Šenauerová, Sylva   +4 more
core   +2 more sources