Results 11 to 20 of about 37,807 (249)
Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
Molecules, 2021 The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities.
Martha Mantzanidou +2 more
doaj +2 more sources
Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis
Molecules, 2019 Three types of pyrazole-fused heterobicycles, i.e., 1,5-, 1,7-, and 2,5-dihydropyrano[3,2-c]pyrazoles, were synthesized from 4-allyloxy-1H-pyrazoles. A sequence of the Claisen rearrangement of 4-allyloxy-1H-pyrazoles, ruthenium-hydride-catalyzed double ...
Yoshihide Usami +5 more
doaj +2 more sources
, 2021 A rather neglected family of heterocyclic compounds, the 3-pyrazolines or 2,3-dihydro-1H-pyrazoles, has been studied theoretically at the B3LYP/6–311++G(d,p) level to obtain geometries and energies and at the GIAO/B3LYP/6–311++G(d,p) level for NMR ...
Elguero, José +3 more
core +2 more sources
Direct C–H Alkenylation of Functionalized Pyrazoles
Journal of Organic Chemistry, 2016 We have developed inter- and intramolecular C–H alkenylation reactions of pyrazoles. The catalyst, derived from Pd(OAc)2 and pyridine, enabled the oxidative alkenylation of pyrazoles containing a variety of functional groups at the C4 position ...
Su Jin Han (1433359) +2 more
core +2 more sources
Thermal rearrangements of 3H-pyrazoles, 4H-pyrazoles, and cyclopentadienes
, 1992 3H-Pyrazoles generally undergo thermal rearrangement by concerted [1,5]-sigmatropic migrations. It has been discovered that 3H-pyrazoles 111a-e undergo thermal rearrangement by an alterative mechanism.
Jefferson, Anne Elizabeth
core +3 more sources
Amino-Pyrazoles in Medicinal Chemistry: A Review
International Journal of Molecular Sciences, 2023 A pyrazole nucleus is an easy-to-prepare scaffold with large therapeutic potential. Consequently, the search for new pyrazole-based compounds is of great interest to the academic community as well as industry.
Matteo Lusardi +2 more
semanticscholar +1 more source
Skeletal Editing of Pyrimidines to Pyrazoles by Formal Carbon Deletion
Journal of the American Chemical Society, 2022 A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has been achieved guided by computational analysis. The pyrimidine heterocycle is the most common diazine in FDA-approved drugs, and pyrazoles are the most common ...
G. L. Bartholomew +2 more
semanticscholar +1 more source
Copper-Catalyzed Hydroamination: Enantioselective Addition of Pyrazoles to Cyclopropenes
Journal of the American Chemical Society, 2023 Chiral N-cyclopropyl pyrazoles and structurally related heterocycles are prepared using an earth-abundant copper catalyst under mild reaction conditions with high regio-, diastereo-, and enantiocontrol. The observed N2:N1 regioselectivity favors the more
Minghao Wang +5 more
semanticscholar +1 more source
Journal of Molecular Structure, 2022 The discovery and development of new potent antimicrobial and antioxidant agents is an essential lever to protect living beings against pathogenic microorganisms and free radicals.
Mohammed Chalkha +11 more
semanticscholar +1 more source
Recent Advances in Synthesis and Properties of Pyrazoles
Chemistry, 2022 Pyrazole-containing compounds represent one of the most influential families of N-heterocycles due to their proven applicability and versatility as synthetic intermediates in preparing relevant chemicals in biological, physical-chemical, material science,
María-Camila Ríos, J. Portilla
semanticscholar +1 more source