Results 11 to 20 of about 53,373 (308)
Natural and Biomimetic Antitumor Pyrazoles, A Perspective
Molecules, 2020 The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs.
Ana R F Carreira +2 more
exaly +5 more sources
Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities [PDF]
Molecules, 2021 Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives ...
Mohamed Ramadan +4 more
doaj +4 more sources
Enantioselective Addition of Pyrazoles to Dienes [PDF]
Angewandte Chemie, 2021 We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity.
Alexander Y Jiu +4 more
semanticscholar +5 more sources
Regio- and Stereoselective Switchable Synthesis of (E)- and (Z)-N-Carbonylvinylated Pyrazoles
Molecules, 2023 Regio- and stereoselective switchable synthesis of (E)- and (Z)-N-carbonylvinylated pyrazoles is first developed by using the Michael addition reaction of pyrazoles and conjugated carbonyl alkynes.
Xue Zhang +3 more
doaj +2 more sources
Synthesis of Dihydropyrano[3,2-c]pyrazoles via Double Bond Migration and Ring-Closing Metathesis
Molecules, 2019 Three types of pyrazole-fused heterobicycles, i.e., 1,5-, 1,7-, and 2,5-dihydropyrano[3,2-c]pyrazoles, were synthesized from 4-allyloxy-1H-pyrazoles. A sequence of the Claisen rearrangement of 4-allyloxy-1H-pyrazoles, ruthenium-hydride-catalyzed double ...
Yoshihide Usami +5 more
doaj +2 more sources
Molecules, 2018 Synthesis of novel pyrazole-fused heterocycles, i.e., dihydro-1H- or 2H-oxepino[3,2-c]pyrazoles (6 or 7) from 4-allyloxy-1H-pyrazoles (1) via combination of Claisen rearrangement and ring-closing metathesis (RCM) has been achieved.
Yoshihide Usami +3 more
doaj +2 more sources
Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
Molecules, 2021 The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities.
Martha Mantzanidou +2 more
doaj +2 more sources
Beilstein Journal of Organic Chemistry, 2011 An efficient synthesis of 1,3-diaryl-4-halo-1H-pyrazoles was achieved. The synthesis involves the [3 + 2] dipolar cycloaddition of 3-arylsydnones and 2-aryl-1,1-dihalo-1-alkenes. The process proceeds smoothly in moderate to excellent yields. 1,3-Diaryl-4-
Yiwen Yang +4 more
doaj +2 more sources
New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
Molecules, 2021 (1) Background: different previously synthesized pyrazoles and imidazo-pyrazoles showed interesting anti-angiogenic action, being able to interfere with ERK1/2, AKT and p38MAPK phosphorylation in different manners and with different potency; (2) Methods:
Maria Grazia Signorello +5 more
doaj +2 more sources
Direct C-H Alkenylation of Functionalized Pyrazoles.
Journal of Organic Chemistry, 2016 We have developed inter- and intramolecular C–H alkenylation reactions of pyrazoles. The catalyst, derived from Pd(OAc)2 and pyridine, enabled the oxidative alkenylation of pyrazoles containing a variety of functional groups at the C4 position ...
Su-jin Han, Hyun Tae Kim, Jung Min Joo
semanticscholar +2 more sources