Results 11 to 20 of about 20,139 (226)
Revisiting Hydrazine Moiety as a Scaffold for the Synthesis of Potential Antiviral Pyrazole Ribonucleoside Analogues. [PDF]
ChemMedChemThree series of pyrazole ribonucleoside analogues were designed and synthesized. They were evaluated, along with some of their pronucleotides, for their antiviral activity against RNA viruses. Pyrazole ribonucleoside analogues were prepared via a linear approach starting with the reaction of D‐ribosylhydrazine with 1,3‐dicarbonyl or acrylonitrile ...
Guillou A +6 more
europepmc +2 more sources
Crystal and molecular structure of 4-fluoro-1H-pyrazole at 150 K
Acta Crystallographica Section E: Crystallographic Communications, 2023 Only two 4-halo-1H-pyrazole crystal structures are known to date (chloro and bromo, the structure of 4-iodo-1H-pyrazole has not been reported yet). The triclinic structure of 4-fluoro-1H-pyrazole, C3H3FN2 (P\overline{1}), reported here is not isomorphous
Basil M. Ahmed +2 more
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Two CuII complexes of 3,4,5-trimethyl-1H-pyrazole
Acta Crystallographica Section E: Crystallographic Communications, 2018 The crystal structure of complexes of 3,4,5-trimethyl-1H-pyrazole with CuCl2·2H2O and Cu(NO3)2·2.5H2O are presented, namely di-μ-chlorido-bis[chloridobis(3,4,5-trimethyl-1H-pyrazole-κN2)copper(II)], [Cu2Cl4(C6H10N2)4] (1) and aquatetrakis(3,4,5-trimethyl-
Collin J. Vincent +2 more
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Carbamidine-substituted Pyrazoles [PDF]
Nature, 1951 THE ease with which 1-substituted pyrazoles may be converted into the free imino compounds varies with the nature of the 1-substituent and the reacting substance. Thus, 1,3,5-trimethyl pyrazole may be nitrated1 and 1-phenyl pyrazole reduced to the pyrazoline2 without loss of the N-methyl or N-phenyl groups respectively.
F L, SCOTT, C M B, MURPHY, J, REILLY
openaire +2 more sources
Frontiers in Pharmacology, 2020 A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo +7 more
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Frontiers in Oncology, 2022 As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Minsung Kang +13 more
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Beilstein Journal of Organic Chemistry, 2023 An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma +8 more
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Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives
Molecules, 2022 Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained ...
Diana Becerra +2 more
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Current status of pyrazole and its biological activities
Journal of Pharmacy and Bioallied Sciences, 2016 Pyrazole are potent medicinal scaffolds and exhibit a full spectrum of biological activities. This review throws light on the detailed synthetic approaches which have been applied for the synthesis of pyrazole.
Mohd Javed Naim +4 more
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