Results 11 to 20 of about 51,383 (265)
Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries [PDF]
, 2014 Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization (high K+)-, and mechanical ...
Abramowitz, Joel +6 more
core +5 more sources
Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]
, 2015 Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, Mark C +5 more
core +7 more sources
Carbamidine-substituted Pyrazoles [PDF]
Nature, 1951 THE ease with which 1-substituted pyrazoles may be converted into the free imino compounds varies with the nature of the 1-substituent and the reacting substance. Thus, 1,3,5-trimethyl pyrazole may be nitrated1 and 1-phenyl pyrazole reduced to the pyrazoline2 without loss of the N-methyl or N-phenyl groups respectively.
F L, SCOTT, C M B, MURPHY, J, REILLY
openaire +2 more sources
Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis [PDF]
, 2008 As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as ...
Ahmad +27 more
core +1 more source
Effect of building block transformation in covalent triazine‐based frameworks for enhanced CO2 uptake and metal‐free heterogeneous catalysis [PDF]
, 2020 Invited for the cover of this issue is the group of Pascal Van Der Voort at the University of Ghent and colleagues at Technische Universitat Berlin. The image depicts the covalent triazine frameworks reported in the manuscript for the sorption of CO2 and
Jena, Himanshu +5 more
core +2 more sources
Frontiers in Pharmacology, 2020 A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo +7 more
doaj +1 more source
Frontiers in Oncology, 2022 As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Minsung Kang +13 more
doaj +1 more source
Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand. [PDF]
, 2020 The steric effects of substituents on five-membered rings are less pronounced than those on six-membered rings because of the difference in bond angles. Thus, the regioselectivities of reactions of five-membered heteroarenes that occur with selectivities
Hartwig, John F +3 more
core +1 more source
Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives
Molecules, 2022 Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained ...
Diana Becerra +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2023 An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma +8 more
doaj +1 more source