Results 11 to 20 of about 35,216 (249)
Synthesis of pyrazole and pyrazole amidocobaloximes
, 2004 Department of Chemistry, Osmania University, Hyderabad-500 007, India E-mail : ssnsirasani @yahoo.com Manuscript received 23 September 2002, revised 23 April 2003. accepted 11 July 2003 A series of cyano (ligand) cobaloximes have been prepared where, the ligand is pyrazole (Pz), 1-(acetamido)pyrazole (Apz), 1-(N-methylacetamido)pyrazole (MAPz), 1 ...
A. Rajeshwar Rao +3 more
openaire +2 more sources
5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid [PDF]
, 2008 5-Amino-1-phenyl-1H-pyrazole-4-carboxylic ...
Muhammad Zia-ur-Rehman (7162790) +3 more
core +7 more sources
Ethyl 5-amino-1-(4-chloro-2-nitrophenyl)-1H-pyrazole-4-carboxylate [PDF]
, 2009 Ethyl 5-amino-1-(4-chloro-2-nitrophenyl)-1H-pyrazole-4 ...
Muhammad Zia-ur-Rehman (7162790) +4 more
core +7 more sources
Diazophosphonates: Effective Surrogates for Diazoalkanes in Pyrazole Synthesis [PDF]
, 2021 Diazophosphonates, readily prepared from -ketophosphonates by oxidation of the corresponding hydrazones in batch or in flow, are useful partners in 1,3-dipolar cycloaddition reactions to alkynes to give N-H pyrazoles, including the first intramolecular ...
Christopher J. Moody +15 more
core +1 more source
Pyrazole-Derived Antibacterial Compounds Effectively Treat Methicillin-Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase. [PDF]
Adv Sci (Weinh)This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Yang X +11 more
europepmc +2 more sources
Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr-Pyrazole Chemistry. [PDF]
ChemMedChemThe glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Gullick J +4 more
europepmc +2 more sources
Pyrene-linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights. [PDF]
Smart MolA series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Kasundra DV, Patel PN.
europepmc +2 more sources
Crystal and molecular structure of 4-fluoro-1H-pyrazole at 150 K
Acta Crystallographica Section E: Crystallographic Communications, 2023 Only two 4-halo-1H-pyrazole crystal structures are known to date (chloro and bromo, the structure of 4-iodo-1H-pyrazole has not been reported yet). The triclinic structure of 4-fluoro-1H-pyrazole, C3H3FN2 (P\overline{1}), reported here is not isomorphous
Basil M. Ahmed +2 more
doaj +1 more source
2,2′-(1-Phenyl-1H-pyrazole-3,5-diyl)diphenol [PDF]
, 2009 The title compound, C21H16N2O2, was derived from 1-(2-hydroxyphenyl)-3-(-methoxyphenyl)propane-1,3-dione. The molecular structure of the title compound is stabilized by an intramolecular O-H...N hydrogen bond. The dihedral angle between the hydroxyphenyl
Bolte, Michael +9 more
core +1 more source
Two CuII complexes of 3,4,5-trimethyl-1H-pyrazole
Acta Crystallographica Section E: Crystallographic Communications, 2018 The crystal structure of complexes of 3,4,5-trimethyl-1H-pyrazole with CuCl2·2H2O and Cu(NO3)2·2.5H2O are presented, namely di-μ-chlorido-bis[chloridobis(3,4,5-trimethyl-1H-pyrazole-κN2)copper(II)], [Cu2Cl4(C6H10N2)4] (1) and aquatetrakis(3,4,5-trimethyl-
Collin J. Vincent +2 more
doaj +1 more source