Results 31 to 40 of about 51,383 (265)
Chiral versus achiral crystal structures of 4-benzyl-1H-pyrazole and its 3,5-diamino derivative
Acta Crystallographica Section E: Crystallographic CommunicationsThe crystal structures of 4-benzyl-1H-pyrazole (C10H10N2, 1) and 3,5-diamino-4-benzyl-1H-pyrazole (C10H12N4, 2) were measured at 150 K. Although its different conformers and atropenantiomers easily interconvert in solution by annular tautomerism and/or ...
Emily R. Hayward +2 more
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Molecules, 2022 Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic ...
Md. Jahangir Alam +10 more
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Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides
Angewandte Chemie, EarlyView.A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu +4 more
wiley +2 more sources
Chemistry and biomedical relevance of pyrazole derivatives: An integrated review [PDF]
EPJ Web of ConferencesOver the past decades, the interest in the synthesis and applications of different pyrazole derivatives has been increased dramatically. Pyrazole is well known five-member ring found to be present in many plants and microorganisms.
Dubal Gaurang +2 more
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4-[Bis(3-phenyl-1H-pyrazol-1-yl)meth-yl]benzene-1,2-diol [PDF]
, 2011 The title compound, C25H20N4O2, is a ditopic ortho-hydroquinone-based bis(pyrazol-1-yl)methane ligand. The dihedral angles between the planes of the pyrazole rings and their attached phenyl rings are 17.4 (3) and 5.9 (4)°.
Blasberg, Florian +2 more
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Azide‐to‐Diazo Transformation Facilitated by Michael Addition via Phosphazide Formation
Angewandte Chemie, EarlyView.A new type of Michael addition based on azide‐to‐diazo conversion is disclosed. This unusual transformation proceeds via 1,4‐addition accompanied by N─N bond cleavage of phosphazide intermediates under practical conditions. The high versatility of the resulting Michael adducts enables the synthesis of a wide variety of organonitrogen compounds ...
Tomoki Mano +3 more
wiley +2 more sources
Frontiers in ChemistryIn this study, choline chloride/urea was used as a green deep eutectic solvent in the three-component reaction of hydrazine/phenylhydrazine, malononitrile, and aromatic aldehydes for synthesizing pyrazole derivatives, and in the four-component reaction ...
Israa Habeeb Naser +12 more
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2,6-Bis(1-isopropyl-5-phenyl-1H-pyrazol-3-yl)pyridine
Acta Crystallographica Section E, 2008 In the title compound, C29H29N5, the central pyridine ring and the two pyrazole rings are approximately coplanar, the dihedral angles between the pyridine and pyrazole rings being 3.94 (12) and 14.84 (12)°.
Ping Liu +3 more
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Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids
Molecules, 2022 Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activity ...
Patrícia S. M. Amado +5 more
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Palladium-catalyzed difluoromethylation of heteroaryl chlorides, bromides and iodides. [PDF]
, 2017 A palladium-catalyzed difluoromethylation of a series of heteroaryl chlorides, bromides and iodides under mild conditions is described. A wide range of heteroaryl halides such as pyridyl, pyrimidyl, pyrazyl, funanyl, thienyl, pyazolyl, imidazolyl ...
Gu, Yang +4 more
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