Results 51 to 60 of about 36,678 (260)
1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity
, 2021 1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian ...
LG Hall (14447421) +18 more
core
Crystal structure and molecular docking studies of new pyrazole-4-carboxamides
Heterocyclic Communications, 2019 Two pyrazol-4-carboxamides, 3-(difluoromethyl)-N-(mesitylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxa-mide (7a) and 3-(difluoromethyl)-N-((3,5-dimethylphenyl) carbamoyl)-1-methyl-1H-pyrazole-4-carboxamide (7b) were synthesized and their structures were ...
Qiao Li +6 more
doaj +1 more source
Synthesis of Chromone-Related Pyrazole Compounds
Molecules, 2017 Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacentnitrogen- containing heterocycles, represent two important classes of biologically active compounds.
Clementina M. M. Santos +2 more
doaj +1 more source
Novel Pyrazole-4-Carbaldehyde Derivatives Having Potent COX-2 Inhibition and Anti-Tubercular Activity: Microwave-Assisted Green Synthesis and Molecular Docking. [PDF]
J Biochem Mol ToxicolABSTRACT A series of 1‐(4‐Chorophenyl)‐3Aryl‐1‐H‐pyrazole‐4‐carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR, 1H‐NMR, 13C‐NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds.
Kokane M +6 more
europepmc +2 more sources
Angewandte Chemie International Edition, EarlyView.To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler +20 more
wiley +1 more source
Synthesis of Substituted Triazole-Pyrazole Hybrids using Triazenopyrazoles Precursors [PDF]
A synthesis route to access triazole-pyrazole hybrids via pyrazolotriazenes was developed. Contrary to existing methods, this route allows the facile N-functionalization of the pyrazole before the attachment of the triazole unit via a copper-catalyzed ...
Simone, Graessle +6 more
core +2 more sources
, 2022 The target compounds, 3-(4-chlorophenyl)-5-(thiophene-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (I) and 3-(4-methoxyphenyl)-5-(thiophene-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide (II) were synthesized and characterized by XRD, FT-IR and UV-Vis ...
Serap Uzun (12190588)
core +1 more source
Derivatives of pyrazole-based compounds as prospective cancer agents. [PDF]
Five pyrazole-based compounds, 3,5-dimethyl-1H-pyrazole, L1; 3,5-diphenyl-1H-pyrazole, L2; 3-(trifluoromethyl)-5-phenyl-1H-pyrazole, L3; 3-(trifluoromethyl)-5-methyl-1H-pyrazole, L4; and 3,5-ditert-butyl-1H-pyrazole, L5 were synthesized from a typical ...
Manicum, Amanda-Lee E. +8 more
core +4 more sources
Angewandte Chemie International Edition, EarlyView.A pyridine‐containing ligation auxiliary eliminates a major bottleneck of peptide ligation chemistry. The extended range of applicable pH values (2.0–7.5) in the ligation reaction helps to avoid epimerization. Native chemical ligation (NCL) proceeds at virtually any junction, including reactions at β‐branched amino acids, as well as O‐glycosylated or O‐
Sebastian Trunschke +5 more
wiley +1 more source
Synthesis of new pseudo‐C‐nucleosides containing pyrazole rings in their structure [PDF]
, 2004 Synthetic approaches to new 4-(furanos-4-C-yl)-1H-pyrazole and 3-(furanos-4-C-yl)-1H-pyrazole derivatives are described, including its pyrazole-5-carboxylate derivative, which is a pyrazofurin analogue.
Figueiredo, J.A. +3 more
core +1 more source