Results 61 to 70 of about 20,139 (226)

(E)-1-(3,4-Dimethoxyphenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-one

IUCrData
In the title compound, C26H22N2O3, the dihedral angle between the benzene and pyrazole rings of the chalcone unit is 88.3 (1)°. The pyrazole ring has two attached phenyl rings that form dihedral angles with the pyrazole ring of 22.6 (2) and 40.0 (1)°. In
Jiha Sung
doaj   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Microwave versus ultrasound assisted synthesis of some new heterocycles based on pyrazolone moiety

Journal of Saudi Chemical Society, 2010
Different pyrazolone derivatives were prepared by microwave irradiation and ultrasound assisted methods besides the traditional ones. They were used for synthesis of some derivatives of spiropiperidine-4,4′-pyrano[2,3-c]pyrazole, dihydropyrano[2,3-c ...
Aamal A. Al-Mutairi, Fatma E. M. El-Baih, Hassan M. Al-Hazimi   +2 more
doaj   +1 more source

2-{5-[2-(4-Nitrophenoxy)phenyl]-1-phenyl-1H-pyrazol-3-yl}phenol

Acta Crystallographica Section E, 2010
In the title compound, C27H19N3O4, the phenol and pyrazole rings are almost coplanar [dihedral angle = 0.95 (12)°] due to an intramolecular O—H...N hydrogen bond, whereas the phenyl ring is tilted by 40.81 (7)& ...
Ali Haider, Zareen Akhter, Michael Bolte, Muhammad Zia-ul Haq, Humaira M. Siddiqi   +4 more
doaj   +1 more source

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Molecules, 2020
Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past.
Chiara Brullo, Matteo Massa, Federica Rapetti, Silvana Alfei, Maria B. Bertolotto, Fabrizio Montecucco, Maria Grazia Signorello, Olga Bruno   +7 more
doaj   +1 more source

Gold(I)‐Mediated Reactivity of Allenes With Mesoionic Nucleophiles: A Computational Exploration

European Journal of Organic Chemistry, EarlyView.
The regioselective gold(I)‐mediated reactivity of allenes with mesoionic nucleophiles has been evaluated through computational analysis of the mechanisms involved. Instead of typical (3 + 2) pathways, sydnones and münchnones favour the formal (3 + 3) cyclizations affording substituted dihydropyridines.
Eduardo Garcia‐Padilla, Feliu Maseras
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Aqua(4-nitrophthalato)bis[2-(1H-pyrazol-3-yl)pyridine]zinc(II) hemihydrate

Acta Crystallographica Section E, 2011
In the title compound, [Zn(C8H3NO6)(C8H7N3)2(H2O)]·0.5H2O, the ZnII atom shows a distorted octahedral ZnN4O2 coordination environment and is bonded to two 3-(2-pyridyl)-1H-pyrazole ligands via the N atoms, one monodentate 4-nitrophthalate ligand
Hong Wei, Ji-Li Zhao, Lei Ni
doaj   +1 more source

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, EarlyView.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

1,1′-Bis(1-acetyl-5-methyl-1H-pyrazol-3-yl)ferrocene

Acta Crystallographica Section E, 2011
The title compound, [Fe(C11H11N2O)2], crystallizes with two independent molecules in the asymmetric unit which have have different conformations. In one molecule, the two ferrocene cyclopentadienyl rings are fully eclipsed and the two pyrazole rings are ...
Bei-Bei Zhu, Yao-Cheng Shi, Wen-Bin Shen, Qian-Kun Li   +3 more
doaj   +1 more source