Results 81 to 90 of about 51,383 (265)

Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis

Angewandte Chemie International Edition, EarlyView.
Contrary to traditional alkene aziridination via (formal) nitrene transfer, we herein report a strategy that achieves intermolecular aziridination of a single alkene carbon atom and installs an additional group at the other. Enabled by metal‐free energy transfer (EnT) catalysis, alkenyl boronates and silanes are transformed into reactive intermediates ...
Fritz Paulus, Corinna Heusel, Felix H. Wessels, Bünyamin Sikora, Maik G. Niedziella, Kilian van der Beck, Constantin G. Daniliuc, Frank Glorius   +7 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, EarlyView.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source

Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]

, 2019
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam, Alina Secrieru, Alkorta, Andes, Anwar, Behr, Brown, Castillo, Catalan, Chauhan, Clark, Elguero, Elnagdi, Favre, Fichez, Hall, Horta, Katritzky, Katritzky, Kost, Kumar, Larina, Maria Lurdes Santos Cristiano, Mert, Minkin, Minkin, Mohamed, Nagy, Nimbalkar, Paul Michael O’Neill, Schofield, Simons, Szajda, Taylor, Zerbi   +34 more
core   +2 more sources

A Mononuclear Scenario for the Copper‐Catalyzed Monooxygenation of Phenolic Substrates

Chemistry – A European Journal, EarlyView.
ABSTRACT Whereas a dinuclear pathway applies to the monooxygenation of phenols by the type 3 copper enzyme tyrosinase, a mononuclear pathway has been identified for the same reaction in corresponding small‐molecule systems. DFT calculations of five copper model complexes reveal that the latter mechanism is energetically feasible, identifying all ...
Alexander Koch, Antony Memboeuf, Felix Tuczek, Tobias A. Engesser   +3 more
wiley   +1 more source

Efficient Regioselective Iodination of Pyrazole Derivatives Mediated by Cadmium(II) Acetate

ChemistryOpen
The present study focuses on the iodination of pyrazoles mediated by cadmium (II) acetate. The objects of research were compounds with pyrazole rings substituted by N‐propargyl, C, N‐alkyl groups.
Dr. Nina G. Hobosyan, Dr. Kristine V. Balyan, Lusine A. Movsisyan, Dr. Varduhi S. Hovsepyan, Armen G. Ayvazyan, Dr. Henrik A. Panosyan, Prof. Dr. Hovhannes S. Attaryan, Dr. Hmayak B. Sargsyan, Haykanush R. Pogosyan   +8 more
doaj   +1 more source

(E)-1-(3,4-Dimethoxyphenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-one

IUCrData
In the title compound, C26H22N2O3, the dihedral angle between the benzene and pyrazole rings of the chalcone unit is 88.3 (1)°. The pyrazole ring has two attached phenyl rings that form dihedral angles with the pyrazole ring of 22.6 (2) and 40.0 (1)°. In
Jiha Sung
doaj   +1 more source

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Molecules, 2020
Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past.
Chiara Brullo, Matteo Massa, Federica Rapetti, Silvana Alfei, Maria B. Bertolotto, Fabrizio Montecucco, Maria Grazia Signorello, Olga Bruno   +7 more
doaj   +1 more source

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source