Results 101 to 110 of about 36,678 (260)

Alkylating nucleosides. 2. Synthesis and cytostatic activity of bromomethylpyrazole and pyrazole nitrogen mustard nucleosides

, 1979
Glycosylation of ethyl 3(5)-(bromomethyl)pyrazole-5(3)-carboxylate (3) and 3(5)-(bromomethyl)pyrazole-5(3)-carboxamide (4) with poly-O-acetylated sugars via an acid-catalyzed fusion method afforded the corresponding ethyl 3-(bromomethyl)pyrazole-5 ...
Herranz, Rosario, Alonso, Gregorio, García-López, M. Teresa, Rosario Herranz, Gregorio Alonso, M. Teresa Garcia-Lopez   +5 more
core   +1 more source

Development of Radioiodinated Tetrahydropyrazolopyridine Inhibitors Targeting mIDH

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 69, Issue 13-14, November-December 2026.
Iodinated tetrahydropyrazolopyridine ligands show enhanced potency and selectivity for mutant IDH1 compared with their fluorinated counterparts and can be efficiently radiolabeled with I‐125, supporting the basis for further evaluation as mIDH1‐targeting radiotheranostic candidates.
Sarandeep Kaur, Sladjana Dukic‐Stefanovic, Lucie Arnaud, Jean‐Michel Chezal, Barbara Wenzel, Rareş‐Petru Moldovan, Klaus Kopka, Aurélie Maisonial‐Besset   +7 more
wiley   +1 more source

Chloro(phenyl)(1H-pyrazole-kappa N-2)-(triphenylphosphine-kappa P)palladium(II)

, 2004
In the title compound, [Pd(C6H5)Cl(C 3H4N2)(P(C6H5) 3}], the phenyl and Cl ligands lie mutually trans. The compound is the first structurally characterized complex with four monodentate Cl, P, N and (non-carbenoid) C ligands in a square-planar four ...
White, AH (15476111), Allan Canty (14733112), Skelton, BW (15476108)   +2 more
core  

Synthesis of pyrazole-3-carboxylates and pyrazole-1,5-dicarboxylates by one-pot cyclization of hydrazone dianions with diethyl oxalate

, 2008
The one-pot cyclization of hydrazone dianions with diethyl oxalate allows a convenient synthesis of pyrazole-3-carboxylates and pyrazole-1,5-dicarboxylates. © 2007 Elsevier Ltd. All rights reserved.
Görls, H., Fischer, C., Alcívar L, P., Dang, T.T.   +3 more
core   +1 more source

The Boron–Neuron Connection: The Potential of Boron‐Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai, Billy Vuong, Muhammad Shaharyar K. Afridi, Sasha Leggett, Hemin Roghzai, Geoffrey K. Tranmer   +5 more
wiley   +1 more source

Synthesis of pyrazole and pyrazoline derivatives of β-ionone: Exploring anti-inflammatory potential, cytotoxicity, and molecular docking insights

European Journal of Medicinal Chemistry Reports
In the present paper, pyrazole and pyrazoline derivatives of β-ionone were synthesized. The protocol involved intramolecular oxidative C–H amination of hydrazone to yield corresponding pyrazole in moderate to good yields.
Monika Sihag, Anju Manuja, Swati Rani, Rinku Soni, Neha Rani, Sandeep Malik, Kirti Bhardwaj, Balvinder Kumar, Mayank Kinger, Monika Miglani, Deepak Kumar Aneja   +10 more
doaj   +1 more source

Regioselective Diversification of Aminopyrazoles via Ir‐Catalyzed C─H Borylation

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Aminopyrazoles, an important bioactive pharmacophore, are typically accessed inefficiently through de novo syntheses that yield isomeric mixtures of 3‐ and 5‐substituted derivatives. To address this challenge, we have elaborated readily available 3‐ and 5‐aminopyrazole fragments using Ir C─H borylation, regioselectively furnishing boronates for ...
Jay S. Wright, Felipe M. Nogueira, Andrew C. Hones, Mingyan Ding, Mark A. Fox, Wender A. Silva, Angelo H. de Lira Machado, Alpay Dermenci, David C. Blakemore, Patrick G. Steel   +9 more
wiley   +1 more source

Exploration of Pyrazole‐Sulfonamide Hybrids: Synthesis, Molecular Modeling, Potential Antimicrobial, DHFR Inhibitor, and Pharmacokinetic Profile [PDF]

Chem Biol Drug Des
Nine pyrazole‐sulfonamide hybrids 5, 6, and 7 were synthesized and characterized by IR, NMR, and MS. The DFT computations of the built hybrids presented a comparable non‐planar configuration. Comparable HOMO‐LUMO structures were observed, except for the nitro‐derivatives 5c and 6c.
Alharbi A, Ebaid M, Alanzy A, Alalawy A, Abbas B, Alomari K, Attar R, El‐Metwaly N.   +7 more
europepmc   +2 more sources

Peroxiredoxin III and Sulfiredoxin Together Protect Mice from Pyrazole-Induced Oxidative Liver Injury [PDF]

, 2012
Aims: To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress.
이서구, 길인섭, 배수한, 성수행   +3 more
core  

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source