Results 101 to 110 of about 20,139 (226)
Food Science &Nutrition, Volume 14, Issue 6, June 2026.The bioactive composition, antioxidant capacity, and glycemic‐regulating properties of Basella alba L. leaf, fruit, and stem were comparatively analyzed using gas chromatography–mass spectrometry (GC–MS), Fourier‐transform infrared spectroscopy (FTIR), in vitro assays, and molecular docking analyses.
Shorna Das +4 more
wiley +1 more source
Human Liver Alcohol Dehydrogenase: Inhibition by Pyrazole and Pyrazole Analogs. [PDF]
Acta Chemica Scandinavica, 1969 Ting-Kai Li +7 more
openaire +2 more sources
The Role of N6‐Methyladenosine Modification in Health and Disease
MedComm, Volume 7, Issue 6, June 2026.N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview
MedComm, Volume 7, Issue 6, June 2026.The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele +7 more
wiley +1 more source
Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu +4 more
wiley +2 more sources
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.We have established a set of design rules which combine Pd(II) metal coordination, complementary geometries, complementary interligand hydrogen bonding and π─π interactions for predictable self‐assembly of Pd(II)‐based species such as metallo‐foldamers, cyclic species a metallo‐interlocked clippane. The species persist in a combinatorial mixture due to
Jess L. Algar +2 more
wiley +2 more sources
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Syntaxin‐binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18‐1 (STXBP1) C. elegans models demonstrate that 4‐phenylbutyrate (4‐PBA) or related pharmacological chaperones stabilize ...
Aline Frick +2 more
wiley +1 more source
Pest Management Science, Volume 82, Issue 6, Page 5662-5671, June 2026.Baseline susceptibility of Phthorimaea absoluta to novel insecticides isocycloseram and tolfenpyrad was established in Brazil. Diagnostic doses were proposed for early resistance detection. Early tolfenpyrad tolerance and abamectin‐driven cross‐tolerance to isocycloseram via oxidases highlight cross‐resistance risks, emphasizing the need for routine ...
Vitor Quintela +4 more
wiley +1 more source
Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors
Acta Crystallographica Section F, Volume 82, Issue 6, Page 201-207, June 2026.The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima +4 more
wiley +1 more source