Results 121 to 130 of about 36,678 (260)
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma +6 more
wiley +1 more source
Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review
MoleculesHeterocyclic compounds, especially those containing the pyrazole moiety, are highly significant in organic chemistry and possess remarkable and diverse biological properties. The 5-aminopyrazole derivatives are key starting materials for the synthesis of
Dana M. Odeh +3 more
doaj +1 more source
, 2018 Aims: To define the mechanisms underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress.
이서구 +3 more
core +1 more source
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
, 2008 Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716, 1) and an investigation of the effect of replacement of the -CO group in the ...
K. Sairam (23388697) +11 more
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Synthesis of Pyrazole Analogs from Argentatin B
, 1995 The pyrazole derivatives 3'-(2-R-phenyl)[3,2-c]pyrazole-16,24-epoxy-25-hydroxy-9 ,19-cyclostane Va - Vf have been prepared in a three step reaction from argentatin B.
María del R. Arellano +4 more
core +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha +6 more
wiley +2 more sources
TADF‐Active Tetrazole Luminophores for Visible‐Light Functionalization of Nanoparticles and Surfaces
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.A series of tetrazoles are reported that undergo 1,3‐dipolar cycloadditions with alkene and alkyne substrates, generating (dihydro)pyrazole products that exhibit thermally activated delayed fluorescence (TADF). The “photo‐click” reactivity of these tetrazoles is leveraged to functionalize nanoparticles and surfaces with TADF‐active chromophores ...
Ryoga Hojo +11 more
wiley +2 more sources
Pyrazole derivatives as polyethylene oxidative destruction stabilizers
, 2020 The possibility of newly synthesized pyrazole derivatives using as heat stabilizers of high-pressure polyethylene (LDPE): 1-acetyl-4-methyl-3(5)-(2-(3-nitrophenyl)vinyl)-1H-pyrazole (additive 1) and 4benzoyl-3-(2-(4-nitrophenyl)vinyl-5-phenyl-1-tosyl-1H-
Kuz’menok, N. M. +6 more
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