Results 131 to 140 of about 35,216 (249)

Identification of New Anti‐Trypanosoma brucei Leads: An Integrated CRK12‐Guided Virtual Screen With Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
An integrated computational‐experimental workflow enabled CRK12‐guided hit discovery against Trypanosoma brucei under limited structural and ligand data. The workflow of virtual screening and anti‐T. brucei bioassays identified 4 hit compounds, including three low‐micromolar leads (IC50 = 1.47, 0.81, and 1.33 μM). ABSTRACT Human African trypanosomiasis
Qin Li, Chenggong Fu, Jiayi Luo, Qianqian Zhang, Lingling Wang, Xiaomeng Liu, Jiayue Qiu, Xiaoqing Gong, Henry H. Y. Tong, Xiaojun Yao, Dehua Lai, Huanxiang Liu   +11 more
wiley   +1 more source

Long‐Term Impact of Cropping System and Nitrogen Input Quality on Nitrogen Release and Organic Matter Chemistry

European Journal of Soil Science, Volume 77, Issue 5, September–October 2026.
ABSTRACT Long‐term integrated soil management strategies are essential for enhancing soil organic matter (SOM) quality and promoting the availability of mineralizable nitrogen (N). This study employed a tripartite analytical framework to investigate how crop rotations and organic N amendments influence soil N availability and SOM chemistry.
Sevendeep Kaur Chahal, BaoLuo Ma, John Lauzon, Joshua Nasielski, Adam W. Gillespie   +4 more
wiley   +1 more source

Plasma Pharmacokinetic Profile of Fipronil 1% Pour‐On in Cattle: Photodegradation and the Sustained Systemic Persistence of Fipronil Sulfone

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 5, Page 515-524, September 2026.
ABSTRACT This study characterized the long‐term pharmacokinetic profile of a 1% fipronil pour‐on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC–MS/MS.
Stefani Maria Ferreira, Leonila Ester Reinert Raspantini, Giselle Kindlein, Fabiano Barreto, Caroline Andrade Tomaszewski, Tamara dos Santos Castilhos, Daniel Rodrigo Hillesheim, Silvana Lima Górniak, André Tadeu Gotardo   +8 more
wiley   +1 more source

N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison, Jonathan A. Andrews, Agamemnon E. Crumpton, Mireia Sidera Portela, Michael A. Clegg, Damien Valette, Michael C. Willis   +6 more
wiley   +2 more sources

Facile synthesis, ex-vivo and in vitro screening of 3-sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716) a potent CB1 receptor antagonist

, 2008
Facile synthesis of biaryl pyrazole sulfonamide derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxy lic acid piperidin-1-ylamide (SR141716, 1) and an investigation of the effect of replacement of the -CO group in the ...
K. Sairam (23388697), R. Soni (7159256), J. Patel (13962131), S. Jha (22751435), P. Patel (7661720), S. Shedage (23388694), Neha Gandhi (23328028), B. Kumar Srivastava (23388691), V. Pawar (23388700), N. Sadhwani (23388703), P. Mitra (17501709), M. Jain (3964727)   +11 more
core  

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Tailored [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine hybrids as promising anti-inflammatory agents with COX/5-LOX/ROS/IL-6 multifunctional inhibitory activity: design, synthesis, SAR, and <i>in silico</i> study. [PDF]

RSC Adv
Elazony E, Osman NA, Shaldam MA, Abdel-Fattah HA, Ghanim AM.   +4 more
europepmc   +1 more source

Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo, Zhuoyao Chen, Laurine Palluaud, Arpad Kiss, Tibor Novak, Andras Herner, Alex N. Bullock, Virginie Martiny, Andras Kotschy   +8 more
wiley   +1 more source

Discovery of New Pyrazole-Linked Pyridine Derivatives as Multi-Target Anti-Inflammatory Agents With Immunomodulatory Potential. [PDF]

Drug Dev Res
Salem MA, Raslan RR, Gohar NA, Abusaif MS, Ammar YA, Ragab A.   +5 more
europepmc   +1 more source

Influence of Oxidation State on the Catalytic Activity of Iron Catalysts for CO2 Fixation to Cyclic Carbonates

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
Air stable bimetallic iron one‐component systems capable of CO2 cycloaddition to epoxides under 1 bar of pressure of CO2. In this work, one‐component iron catalysts for the atom‐economical reaction of CO2 with epoxides have been used as efficient catalysts for the carbon dioxide cycloaddition into cyclic carbonates in excellent yields.
María P. Caballero, Marta Navarro, Marc Martínez de Sarasa Buchaca, Jesús Naranjo, Alberto Moreno‐Fernandez, Antonio Rodríguez‐Diéguez, Pablo Salcedo‐Abraira, José A. Castro‐Osma, Juan Tejeda, Felipe de la Cruz‐Martínez, Agustín Lara‐Sánchez   +10 more
wiley   +1 more source