Results 151 to 160 of about 36,678 (260)

Tuning the Molecular Rotor Dynamics of Pyrrolo[3,4‐b]Pyridin‐5‐Ones: Steric and Electronic Control of Environmental Sensing

Luminescence, Volume 41, Issue 10, October 2026.
Pyrrolo[3,4‐b]pyridin‐5‐ones are assembled in one pot manner through an Ugi‐Zhu reaction coupled to a cascade sequence (aza Diels‐Alder/N‐acylation/decarboxylation/dehydration). Pyrrolo[3,4‐b]pyridin‐5‐ones are fluorescence probes for local viscosity, polarity, protic environments, and solid‐state emission.
Ivette Morales‐Salazar, Carlos E. Garduño Albino, Alejandro Valderrama‐Celestino, Federico González‐García, Alberto Rojas, Annia Galano, Yoarhy A. Amador‐Sánchez, Cesar A. Guarin, Eduardo González‐Zamora, Alejandro Islas‐Jácome   +9 more
wiley   +1 more source

Design, synthesis and antifungal activity of pyrazole ester derivatives. [PDF]

RSC Adv
Shen Y, Si WJ, Feng JG, Yang WC, Wang JJ.   +4 more
europepmc   +1 more source

Chlorothiophene‐Substituted N‐Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX‐2 Inhibition

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Eight novel N‐phenylpyrazoline derivatives bearing chlorothiophene moieties were synthesized and evaluated for anticancer activity against T47D, MCF7, and WiDr cell lines. Compound 2g showed the strongest cytotoxicity against WiDr cells (IC50 = 19.63 µg/mL) with the highest selectivity index (665.88), highlighting its potential as a selective ...
Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih   +4 more
wiley   +1 more source

Novel benzofuran-furan-pyrano[2,3-<i>c</i>]pyrazole hybrids as potential anticancer agents: design, synthesis, <i>in silico</i> profiling, and multi-mechanistic biological evaluation. [PDF]

RSC Adv
Hutanu ED, Najri BA, Abdelsalam AH, Saidi KM, Arslan S, Kivrak A.   +5 more
europepmc   +1 more source

Copper-catalyzed radical carbonylation platform for the synthesis of <i>N</i>-acyl azoles under 1 bar of CO. [PDF]

Chem Sci
Dai M, Yang ML, Wu XF.
europepmc   +1 more source

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors. [PDF]

ChemMedChem
Lusardi M, Astigiano C, Bellitto D, Raineri M, Guccione G, Salis A, Cichero E, Brullo C, Ponassi M, Bruzzone S, Spallarossa A.   +10 more
europepmc   +1 more source

Green MW/US‐Assisted Construction of Pyrano[2,3‐b]pyridines and Pyrazolo[3,4‐d]pyrimidinones: Pathway Control and Antibacterial Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A rapid, green MW/US‐assisted route was developed for synthesizing coumarin/azacoumarin‐based fused heterocycles. It enables efficient construction of pyrano[2,3‐b]pyridines and pyrazolo[3,4‐d]pyrimidinones under mild conditions. FT‐IR, NMR, MS, and elemental analysis fully confirmed the structures of the new products.
Sultanah M. Alhunayhin, Ayman M. Algohary, Youssef O. Al‐Ghamdi, Mohamed Abdel‐Megid, Asmaa M. Fahim, Sameh A. Rizk   +5 more
wiley   +1 more source

Fluorogenic Sydnones for Bioorthogonal Labeling of DNA

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
Conjugates of sydnones with cyanine‐styryl dyes combine bioorthogonal reactivity with fluorogenicity. The reactivity with bicyclo[6.1.0]non‐4‐yne (BCN)‐modified DNA showed second‐order rate constants of up to k2 = 2,300 M−1s−1 and fluorescence turn‐on by one magnitude of order.
Kerstin Müller, Hans‐Achim Wagenknecht   +1 more
wiley   +1 more source

Synthesis of Zwitterionic Tris(pyrazolyl) Ligands and Their Mn(II) Bis‐Chelates Exhibiting Charge–Transfer‐Induced Spin Crossover

European Journal of Inorganic Chemistry, Volume 29, Issue 28, 1 October 2026.
In this article, a series of zwitterionic scorpionate ligands based on the anionic tris‐(pyrazolyl)borate ligand scaffold is presented. These ligands are used to prepare bis‐chelates with divalent manganese ions. The resulting complexes are studied via magnetic, crystallographic, and electrochemical means to characterize the charge–transfer‐induced ...
Matthew C. Kessinger, Tzu‐Ching Cheng, Cameron Brillhart, Sreenivasulu Chinnabattigalla, Carla Slebodnick, Amanda J. Morris   +5 more
wiley   +1 more source