PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer [PDF]
Frontiers in Oncology, 2022 As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Kyu Myung Lee +2 more
exaly +4 more sources
NSC 18725, a Pyrazole Derivative Inhibits Growth of Intracellular Mycobacterium tuberculosis by Induction of Autophagy [PDF]
Frontiers in Microbiology, 2020 The increasing incident rates of drug-resistant tuberculosis (DR-TB) is a global health concern and has been further complicated by the emergence of extensive and total drug-resistant strains.
Ramandeep Singh +2 more
exaly +4 more sources
Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative [PDF]
Pharmaceutics, 2019 In a previous study, the specific NOX1/2/4 inhibitor Ewha-18278 was confirmed as a possible treatment for osteoporosis both in vitro and in vivo. Here, we investigated the pharmacokinetics (PK) of the compound by intravenous (IV) and oral administrations
Jaeok Lee, Kee-In Lee, Hwa Jeong Lee
exaly +4 more sources
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics [PDF]
Current Issues in Molecular Biology, 2022 Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern.
Fatima Ezzahra Bennani +9 more
doaj +2 more sources
Design, synthesis, biological assessment, and integrated computational analysis of new pyrazole-based antimicrobial candidates [PDF]
Scientific ReportsThe emergence of antimicrobial resistance needs the development of new chemotherapeutic scaffolds. Pyrazole derivatives are recognized for their broad biological activity; however, further structural innovation is required to enhance antimicrobial ...
Eman A. E. El-Helw +4 more
doaj +2 more sources
Frontiers in Physiology, 2018 The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications.
Ricardo Menegatti +2 more
exaly +3 more sources
(3,5-Di-tert-butylphenyl)(1H-pyrazol-1-yl)methanone
Molbank, 2022 The acyl pyrazole derivative (3,5-di-tert-butylphenyl)(1H-pyrazol-1-yl)methanone was prepared simply and rapidly in 86% isolated yield by means of an oxidative functionalization reaction of an aldehyde with pyrazole.
Katrina E. Doherty +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo +7 more
doaj +1 more source
3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile
Acta Crystallographica Section E, 2012 In the title pyrazole derivative, C19H15N3O, the central pyrazole ring makes dihedral angles of 42.71 (9) and 61.34 (9)°, respectively, with the phenyl and p-tolyl rings.
Hatem A. Abdel-Aziz +3 more
doaj +1 more source
Journal of Chemistry, 2014 Condensation of 2-(benzothiazol-2-yl)acetonitrile (1) or 2-(1-methyl-1H-benzimidazol-2-yl)acetonitrile (2) with thiophene-2-carbaldehyde afforded the corresponding acrylonitrile derivatives 3 or 4, respectively.
Nabila A. Kheder +3 more
doaj +1 more source