PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer [PDF]
Frontiers in Oncology, 2022 As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Minsung Kang +13 more
doaj +3 more sources
NSC 18725, a Pyrazole Derivative Inhibits Growth of Intracellular Mycobacterium tuberculosis by Induction of Autophagy [PDF]
Frontiers in Microbiology, 2020 The increasing incident rates of drug-resistant tuberculosis (DR-TB) is a global health concern and has been further complicated by the emergence of extensive and total drug-resistant strains.
Garima Arora +10 more
doaj +3 more sources
3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile
Acta Crystallographica Section E, 2012 In the title pyrazole derivative, C19H15N3O, the central pyrazole ring makes dihedral angles of 42.71 (9) and 61.34 (9)°, respectively, with the phenyl and p-tolyl rings.
Hatem A. Abdel-Aziz +3 more
doaj +2 more sources
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics [PDF]
Current Issues in Molecular Biology, 2022 Despite continual efforts being made with multiple clinical studies and deploying cutting-edge diagnostic tools and technologies, the discovery of new cancer therapies remains of severe worldwide concern.
Fatima Ezzahra Bennani +9 more
doaj +2 more sources
Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative [PDF]
Pharmaceutics, 2019 In a previous study, the specific NOX1/2/4 inhibitor Ewha-18278 was confirmed as a possible treatment for osteoporosis both in vitro and in vivo. Here, we investigated the pharmacokinetics (PK) of the compound by intravenous (IV) and oral administrations
Seul Gee Lee +5 more
doaj +2 more sources
Design, synthesis, biological assessment, and integrated computational analysis of new pyrazole-based antimicrobial candidates [PDF]
Scientific ReportsThe emergence of antimicrobial resistance needs the development of new chemotherapeutic scaffolds. Pyrazole derivatives are recognized for their broad biological activity; however, further structural innovation is required to enhance antimicrobial ...
Eman A. E. El-Helw +4 more
doaj +2 more sources
Investigation of the anti-inflammatory and analgesic activities of promising pyrazole derivative.
European Journal of Pharmaceutical Sciences, 2021 The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to patients suffering from chronic course pain and inflammatory ...
A. Bekhit +7 more
semanticscholar +1 more source
(3,5-Di-tert-butylphenyl)(1H-pyrazol-1-yl)methanone
Molbank, 2022 The acyl pyrazole derivative (3,5-di-tert-butylphenyl)(1H-pyrazol-1-yl)methanone was prepared simply and rapidly in 86% isolated yield by means of an oxidative functionalization reaction of an aldehyde with pyrazole.
Katrina E. Doherty +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo +7 more
doaj +1 more source
Journal of Chemistry, 2014 Condensation of 2-(benzothiazol-2-yl)acetonitrile (1) or 2-(1-methyl-1H-benzimidazol-2-yl)acetonitrile (2) with thiophene-2-carbaldehyde afforded the corresponding acrylonitrile derivatives 3 or 4, respectively.
Nabila A. Kheder +3 more
doaj +1 more source