Results 31 to 40 of about 1,937,826 (232)

A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase

Scientific Reports, 2016
Osteoclast cells (OCs) are differentiated from bone marrow-derived macrophages (BMMs) by activation of receptor activator of nuclear factor κB (NF-κB) ligand (RANKL).
J. Joo, J. Huh, Jee Hyun Lee, D. Park, Yoonji Lee, Seul-Gee Lee, Sun Choi, H. Lee, Seong-Won Song, Yongmi Jeong, Ja-Il Goo, Yongseok Choi, H. Baek, Sun-Shin Yi, Soojin Park, J. E. Lee, S. Ku, W. Lee, Kee-In Lee, Soo Young Lee, Y. Bae   +20 more
semanticscholar   +1 more source

(4Z)-4-[(2E)-1-Hydroxy-3-(4-methoxyphenyl)prop-2-enylidene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

Acta Crystallographica Section E, 2009
The title compound, C20H18N2O4, is a chalcone derivative of pyrazole. The pyrazole ring is inclined at a dihedral angle of 19.29 (12)° to the methoxyphenyl ring mean plane, and by 1.19 (13)° to the phenyl ring.
Mukhtar-ul-Hassan, Sohail Nadeem, Misbahul Ain Khan, Munawar Ali Munawar, Khizar Iqbal Malik   +4 more
doaj   +1 more source

Cobalt‐Catalyzed [2σ+2π] Cycloaddition via Site‐Selective Capture of Bicyclobutane Diradical

Angewandte Chemie, EarlyView.
We report a Co(II)‐catalyzed strategy that combines thermal activation of bicyclo[1.1.0]butane (BCBs) with site‐selective radical capture to furnish head‐to‐head fused bicyclo[2.1.1]hexanes via [2σ+2π] cycloaddition with indoles. Detailed mechanistic studies (31P NMR, EPR, CV, and DFT) support the catalytic pathway, while phosphine‐oxide trapping and X‐
Tanmayee Nanda, Alexander Umanzor, Julia Gartzke, Jeremy T. Maddigan‐Wyatt, Philipp Thielert, Stefan Weber, Sabine Richert, Shuming Chen, Daniel B. Werz   +8 more
wiley   +2 more sources

2-[(2,6-Dimethylmorpholin-4-yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl}ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol

Molbank, 2017
A novel di-Mannich derivative of curcumin pyrazole, 2-[(2,6-dimethyl morpholin-4-yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl}ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol (2), has been synthesized ...
Joko Untung, Iskandarsyah Iskandarsyah, Hayun Hayun   +2 more
doaj   +1 more source

Reactions of Some Pyrazole-3-Carboxylic Acids and Carboxylic Acid Chlorides with Various O- and N- Nucleophiles

, 2020
The 1H-pyrazole-3-carboxylic acid 2 and its remarkably stable acid chlorides 3 can easily be converted into the corresponding carbohydrazide, ester or amide derivatives 4, 6 and 7, respectively, from reaction with alcohols or N-nucleophiles.
İLHAN, İLHAN ÖZER, Akkoc, Senem, ÇADIR, MEHMET, Onal, Zulbiye, Caglayan, Ayse   +4 more
core   +1 more source

Synthesis and Chemical Characterisation of Some New Diheteroaryl Thienothiophene Derivatives

Molecules, 2011
Treatment of 1-(5-acetyl-3,4-dimethythieno[2,3-b]thiophene-2yl)ethanone (1) with dimethylformamide dimethyl acetal afforded enaminone derivative 2, which reacted with amino derivatives to give the corresponding bis-pyrimidine, bis-pyrazole, bis-triazolo ...
Abdullah S. Alamary, Abdullah Mohammad Al-Majid, Yahia Nasser Mabkhot   +2 more
doaj   +1 more source

Curcumin–Triterpene Type Hybrid as Effective Sonosensitizers for Sonodynamic Therapy in Oral Squamous Cell Carcinoma

Pharmaceutics, 2023
Sonodynamic therapy (SDT) is a non-invasive therapeutic modality in cancer treatment that combines low-intensity ultrasound (US) and sonosensitizers. Tumor cells are destroyed through the synergistic effects of ultrasound and a chemical sonosensitizer ...
Katarzyna Sowa-Kasprzak, Małgorzata Józkowiak, Dorota Olender, Anna Pawełczyk, Hanna Piotrowska-Kempisty, Lucjusz Zaprutko   +5 more
doaj   +1 more source

In Vitro Antimicrobial Evaluation, Single-Point Resistance Study, and Radiosterilization of Novel Pyrazole Incorporating Thiazol-4-one/Thiophene Derivatives as Dual DNA Gyrase and DHFR Inhibitors against MDR Pathogens

ACS Omega, 2022
A series of thiazol-4-one/thiophene-bearing pyrazole derivatives as pharmacologically attractive cores were initially synthesized using a hybridization approach.
Hazem Ali Mohamed, Y. Ammar, G. Elhagali, H. A. Eyada, D. S. Aboul-Magd, A. Ragab   +5 more
semanticscholar   +1 more source

Data_Sheet_4_Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease.PDF

, 2022
Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides ...
Junhuai Zu (11897600), Guangyu Qin (11897597), Jun Yang (2084), Yihui Ma (10522205), Dangwei Yang (11897594)   +4 more
core   +1 more source

Origin of Enhanced Efficiency and Reduced Roll‐Off in Organic Light‐Emitting Diodes Based on Pt(II) Complexes

Advanced Science, EarlyView.
Controlled Pt–Pt fine structure in square‐planar Pt(II) complexes governs metal–metal‐to‐ligand charge‐transfer (MMLCT) state formation, exciton dynamics, and organic light‐emitting diode performance. Short Pt–Pt contacts in Pt(fppz)2 enable coherent metal–metal coupling, sub‐microsecond emission and an external quantum efficiency of 29%, whereas ...
Atul Shukla, Sarah K. M. McGregor, Julian A. Steele, Innes K. Gale, Kiyoshi Miyata, Monirul Hassan, Christian McDonald, Romain J. Lepage, Eduardo Solano, Pilankatta K. Ramya, Cherumuttathu H. Suresh, Takumi Ehara, Chihaya Adachi, Ken Onda, Shih‐Chun Lo, Ebinazar B. Namdas   +15 more
wiley   +1 more source