Results 51 to 60 of about 340,649 (242)
Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
Life, 2023 Curcumin (CUR) is a natural molecule that is unstable due to the presence of a bis-ketone. To obtain more stable derivatives in biological fluids, the bis-ketone was replaced with pyrazole or O-substituted oximes.
Giordana Feriotto +8 more
doaj +1 more source
Advanced Science, EarlyView.This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
Synthesis and oxidation of some azole-containing thioethers
Beilstein Journal of Organic Chemistry, 2011 Pyrazole and benzotriazole-containing thioethers, namely 1,5-bis(3,5-dimethylpyrazol-1-yl)-3-thiapentane, 1,8-bis(3,5-dimethylpyrazol-1-yl)-3,6-dithiaoctane and 1,3-bis(1,2,3-benzotriazol-1-yl)-2-thiapropane were prepared and fully characterized ...
Andrei S. Potapov +4 more
doaj +1 more source
Advanced Science, EarlyView.Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh +7 more
wiley +1 more source
Synthesis of a 2-Furylpyrazoline Derivative Using Microwave Irradiation
Molbank, 2009 A simple method for the synthesis of pyrazoline derivative containing furan moiety was developed. Thus, 5-(6-bromo-1,3-benzodioxol-5-yl)-3-(2-furyl)-1-(3-methyl-phenyl)-4,5-dihydro-1H-pyrazole was synthesized using microwave irradiation and it was ...
Suban Syed Shafi +1 more
doaj +1 more source
Hierarchy of Intermolecular Interactions in Highly Luminescent Pyrenyl-Pyrazole-Aldehyde
, 2022 The intricacies of the crystal structure and the hierarchy of intermolecular interactions in a highly luminescent pyrene-pyrazole-aldehyde (PPPcA) are hereby analyzed by means of experimental charge density analysis, periodic DFT calculations, and high ...
Daniel Mariusz Tchoń (14308901) +5 more
core +1 more source
Advanced Science, EarlyView.Controlled Pt–Pt fine structure in square‐planar Pt(II) complexes governs metal–metal‐to‐ligand charge‐transfer (MMLCT) state formation, exciton dynamics, and organic light‐emitting diode performance. Short Pt–Pt contacts in Pt(fppz)2 enable coherent metal–metal coupling, sub‐microsecond emission and an external quantum efficiency of 29%, whereas ...
Atul Shukla +15 more
wiley +1 more source
3-Ethyl-4-methyl-1H-pyrazol-2-ium-5-olate
Acta Crystallographica Section E, 2011 The title compound, C6H10N2O, is a zwitterionic pyrazole derivative. The crystal packing is predominantly governed by a three-center iminium–amine N+—H...O−...H—N interaction, leading to an undulating sheet-like ...
R. S. Rathore +4 more
doaj +1 more source
Scientific ReportsPyrazole derivatives are aromatic heterocyclic compounds endowed with multifaceted applications. In the present study 1,3,4-trisubstituted pyrazoles derivatives have been synthesized for the purpose of studying their physical properties and their ...
Poonam Devi +3 more
doaj +1 more source