Results 61 to 70 of about 15,779 (274)

Study of physiochemical properties of trisubstituted pyrazole derivatives using polar aprotic solvents

Scientific Reports
Pyrazole derivatives are aromatic heterocyclic compounds endowed with multifaceted applications. In the present study 1,3,4-trisubstituted pyrazoles derivatives have been synthesized for the purpose of studying their physical properties and their ...
Poonam Devi, Hardeep Anand, Rashmi Pundeer, Suresh Kumar   +3 more
doaj   +1 more source

Efficient synthesis, reactions and spectral characterization of pyrazolo[4’,3’:4,5]thieno[3,2-d] pyrimidines and related heterocycles

Heterocyclic Communications, 2019
New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M., Kamal El-Dean Adel M., Radwan Shaban M., Saber Ahmed F.   +3 more
doaj   +1 more source

The biological activity of new thieno[2,3-c]pyrazole compounds as anti-oxidants against toxicity of 4-nonylphenol in Clarias gariepinus

Toxicology Reports, 2015
Synthesis of bi functionally substituted thieno[2,3-c]pyrazole compounds was carried out by a new method. The substituted group at position five is namely (carbonitrile, carboxamide, N-(substitutedphenyl) carboxamide and benzoyl group). Chloroacetylation
Alaa El-Din H. Sayed, Remon M. Zaki, Adel M. Kamal El-Dean, Abdullah Y. Abdulrazzaq   +3 more
doaj   +1 more source

Spectroscopic and Computational Studies of Reversible O\u3csub\u3e2\u3c/sub\u3e Binding by a Cobalt Complex of Relevance to Cysteine Dioxygenase [PDF]

, 2017
The substitution of non-native metal ions into metalloenzyme active sites is a common strategy for gaining insights into enzymatic structure and function.
Fiedler, Adam T., Fischer, Anne A., Lindeman, Sergey V.   +2 more
core   +1 more source

1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes [PDF]

, 2010
2-Thio-3-chloroacrylamides undergo 1,3-dipolar cycloadditions with diazoalkanes leading to a series of novel pyrazolines and pyrazoles. The mechanistic and synthetic features of the cycloadditions to the 2-thio-3-chloroacrylamides at both the sulfide and
Kissane, Marie, Lawrence, Simon E., Maguire, Anita R.   +2 more
core   +1 more source

Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor [PDF]

, 2013
The urokinase receptor (uPAR) is a cell-surface protein that is part of an intricate web of transient and tight protein interactions that promote cancer cell invasion and metastasis. Here, we evaluate the binding and biological activity of a new class of
Knabe, William Eric, Li, Liwei, Liu, Degang, Mani, Timmy, Meroueh, Samy O., Oh, Kyungsoo, Wang, Fang, Zhou, Donghui   +7 more
core   +1 more source

Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis

Angewandte Chemie International Edition, EarlyView.
Contrary to traditional alkene aziridination via (formal) nitrene transfer, we herein report a strategy that achieves intermolecular aziridination of a single alkene carbon atom and installs an additional group at the other. Enabled by metal‐free energy transfer (EnT) catalysis, alkenyl boronates and silanes are transformed into reactive intermediates ...
Fritz Paulus, Corinna Heusel, Felix H. Wessels, Bünyamin Sikora, Maik G. Niedziella, Kilian van der Beck, Constantin G. Daniliuc, Frank Glorius   +7 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

UTILITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS

Zagazig Journal of Pharmaceutical Sciences, 1997
2-Hydrazino-4,6-dimethy1pyridine (1) readily underwent ring closure with benzoy1 chloride to give 5,7 dimethy1-3-pheny1-1,2,4-triazolo[4,3,-a]pyrimidine (4a). Either N-benzoyl derivative (2) or the hydrazone (3a) can be used for the formation of compound
Mohamed AL Ashmawy , Zakaria Abd El-Samii , Said El-Feky , Nermin Osman   +3 more
doaj   +1 more source

Microwave assisted pyrazole derivative synthesis [PDF]

, 2007
In the past few decades, many significant advances in organic chemistry, such as the novel synthetic reagents and methods, as well as the advent of an array of analytical apparatus and techniques, have made the organic synthesis more dynamic and ...
Dash, Binay Kumar
core