Results 61 to 70 of about 15,610 (266)
Heterocyclic Communications, 2019 New pyrazolothienopyrimidines were synthesized. The key intermediate 4-aminothieno[2,3-c]pyrazole-5-carbonitrile 1 was converted to the chloroacetyl amino derivative 2 followed by nucleophilic substitution and Dimorth rearrangement upon treatment with ...
Zaki Remon M. +3 more
doaj +1 more source
Toxicology Reports, 2015 Synthesis of bi functionally substituted thieno[2,3-c]pyrazole compounds was carried out by a new method. The substituted group at position five is namely (carbonitrile, carboxamide, N-(substitutedphenyl) carboxamide and benzoyl group). Chloroacetylation
Alaa El-Din H. Sayed +3 more
doaj +1 more source
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities [PDF]
, 2017 Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new ...
Coluccia, A. +9 more
core +1 more source
Scientific ReportsPyrazole derivatives are aromatic heterocyclic compounds endowed with multifaceted applications. In the present study 1,3,4-trisubstituted pyrazoles derivatives have been synthesized for the purpose of studying their physical properties and their ...
Poonam Devi +3 more
doaj +1 more source
Spectroscopic and Computational Studies of Reversible O\u3csub\u3e2\u3c/sub\u3e Binding by a Cobalt Complex of Relevance to Cysteine Dioxygenase [PDF]
, 2017 The substitution of non-native metal ions into metalloenzyme active sites is a common strategy for gaining insights into enzymatic structure and function.
Fiedler, Adam T. +2 more
core +1 more source
Synthesis of 4,4-Difluoro-1H-pyrazole Derivatives [PDF]
Synlett, 2014 Fluorination of 3,5-diarylpyrazole substrates by SelectfluorTM in acetonitrile gave 4,4-difluoro-1H-pyrazoles in addition to 4-fluoropyrazole derivatives. The structure of this new class of fluorinated heterocycle was established by X-ray crystallography.
Breen, J.R. +3 more
openaire +3 more sources
Oxidoperoxidomolybdenum(VI) complexes with acylpyrazolonate ligands: synthesis, structure and catalytic properties [PDF]
, 2018 Oxidoperoxido–molybdenum(VI) complexes containing acylpyrazolonate ligands were obtained by reaction of [Mo(O)(O)2(H2O)n] with the corresponding acylpyrazolone compounds HQR.
Begines, Emilio +7 more
core +1 more source
New chemistry of diazafulvenium methides: one way to pyrazoles [PDF]
, 2006 Diazafulvenium methides generated from the solution pyrolysis of pyrazolo[1,5-c][1,3]thiazole-2,2-dioxides participate in [8[pi]+2[pi]] cycloadditions giving pyrazolo[1,5-a]pyridine derivatives.
Gonsalves, António M. d'A. Rocha +2 more
core +1 more source
Microwave assisted pyrazole derivative synthesis [PDF]
, 2007 In the past few decades, many significant advances in organic chemistry, such as the novel synthetic reagents and methods, as well as the advent of an array of analytical apparatus and techniques, have made the organic synthesis more dynamic and ...
Dash, Binay Kumar
core
Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor [PDF]
, 2013 The urokinase receptor (uPAR) is a cell-surface protein that is part of an intricate web of transient and tight protein interactions that promote cancer cell invasion and metastasis. Here, we evaluate the binding and biological activity of a new class of
Knabe, William Eric +7 more
core +1 more source