Results 41 to 50 of about 7,294 (164)

Evaluation of 3,5-Diphenyl-2-Pyrazolines for Antimitotic Activity by Inhibition of Tubulin Polymerization

Journal of Chemistry, 2022
Chalcones have a skeleton of diphenyls connected via an α,β-unsaturated carbonyl group. Many chalcone derivatives have been shown to interact with tubulin. Based on previous reports, chalcones derived by substitution of a carbonyl group with 2-pyrazoline
Soon Young Shin, Euitaek Jung, Young Han Lee, Yoongho Lim, Seunghyun Ahn, Dongsoo Koh   +5 more
doaj   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

UTILITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS

Zagazig Journal of Pharmaceutical Sciences, 1997
2-Hydrazino-4,6-dimethy1pyridine (1) readily underwent ring closure with benzoy1 chloride to give 5,7 dimethy1-3-pheny1-1,2,4-triazolo[4,3,-a]pyrimidine (4a). Either N-benzoyl derivative (2) or the hydrazone (3a) can be used for the formation of compound
Mohamed AL Ashmawy , Zakaria Abd El-Samii , Said El-Feky , Nermin Osman   +3 more
doaj   +1 more source

New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.

Marine Drugs, 2017
Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella.
Amin Mokhlesi, Rudolf Hartmann, Tibor Kurtán, Horst Weber, Wenhan Lin, Chaidir Chaidir, Werner E. G. Müller, Georgios Daletos, Peter Proksch   +8 more
doaj   +1 more source

The Jekyll and Hyde Nature of Tetrazoles in Polymer Science: From Intrinsic Electronic Duality to Programmable Macromolecular Function

Angewandte Chemie International Edition, EarlyView.
Tetrazoles are reframed as substitution‐programmable heterocycles rather than static functional groups in polymer chemistry. By linking electronic identity to synthetic strategy and polymer architecture, this mini‐review establishes a design framework for translating tetrazole duality into predictable macromolecular function.
Meryem S. Akdemir, Hatice Mutlu
wiley   +1 more source

Crystal structure of ethyl 4-[(1H-pyrazol-1-yl)methyl]benzoate

Acta Crystallographica Section E, 2014
In the title molecule, C13H14N2O2, the dihedral angle between the pyrazole and benzene ring mean planes is 76.06 (11)°, and the conformation of the ethyl side chain is anti [C—O—C—C = −175.4 (3)°].
Ju-Xian Wang, Chao Feng
doaj   +1 more source

BODIPY‐based J‐aggregates: From supramolecular chemistry to NIR bioimaging and phototherapies

Bulletin of the Korean Chemical Society, EarlyView.
BODIPY dyes form ordered J‐aggregates through controlled supramolecular self‐assembly, producing narrow, red‐shifted absorption bands with small Stokes shifts. This review highlights design strategies governing J‐aggregation, structure–property relationships, and applications in sensing, bioimaging, and phototherapy, guiding functional BODIPY‐based ...
Pooja Sharma, Yeonkyeong Lee, Youngmi Kim   +2 more
wiley   +1 more source

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Frontiers in Physiology, 2018
The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications.
Neidiane R. Trindade, Paulo R. Lopes, Lara M. Naves, James O. Fajemiroye, Pedro H. Alves, Nathalia O. Amaral, Luciano M. Lião, Ana C. S. Rebelo, Carlos H. Castro, Valdir A. Braga, Ricardo Menegatti, Gustavo R. Pedrino   +11 more
doaj   +1 more source

The Stabilization of High‐Nitrogen Systems: 10 Catenated Nitrogen Chain

Chemistry – A European Journal, EarlyView.
Improving the understanding of high‐nitrogen materials. ABSTRACT High‐nitrogen materials have attracted intense interest in recent decades due to their unique chemical, physical, and biological properties. Stabilizing high‐nitrogen materials is often challenging as they become more unstable with increasing nitrogen catenation and nitrogen mass ...
Nicholas F. Scherschel, Thomas R. Talbot IV, Matthias Zeller, Davin G. Piercey   +3 more
wiley   +1 more source

Two tautomers in the same crystal: 3-(4-fluorophenyl)-1H-pyrazole and 5-(4-fluorophenyl)-1H-pyrazole

Acta Crystallographica Section E, 2014
The title co-crystal, 3-(4-fluorophenyl)-1H-pyrazole–5-(4-fluorophenyl)-1H-pyrazole (1/1), C9H7FN2, crystallizes with four independent molecules (A, B, C and D) in the asymmetric unit exhibiting two tautomeric forms (A and D; B and C) due to N—H proton ...
Thammarse S. Yamuna, Manpreet Kaur, Jerry P. Jasinski, Brian J. Anderson, H. S. Yathirajan   +4 more
doaj   +1 more source