Results 41 to 50 of about 1,937,826 (232)

3,5-Dimethyl-1-(4-nitrophenyl)-1H-pyrazole

Acta Crystallographica Section E, 2012
In the title pyrazole derivative, C11H11N3O2, the benzene ring is twisted [dihedral angle = 31.38 (12)°] with respect to the pyrazole ring (r.m.s. deviation = 0.009 Å).
Edward R. T. Tiekink, Solange M. S. V. Wardell, James L. Wardell   +2 more
doaj   +1 more source

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

Scientific Reports, 2015
Accumulating evidence suggests that deposition of neurotoxic α-synuclein aggregates in the brain during the development of neurodegenerative diseases like Parkinson’s disease can be curbed by anti-aggregation strategies that either disrupt or eliminate ...
Nuzhat Ahsan, Satyendra Mishra, M. Jain, A. Surolia, Sarika Gupta   +4 more
semanticscholar   +1 more source

Data_Sheet_3_Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease.PDF

, 2022
Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides ...
Junhuai Zu (11897600), Guangyu Qin (11897597), Jun Yang (2084), Yihui Ma (10522205), Dangwei Yang (11897594)   +4 more
core   +1 more source

Efficient Regioselective Iodination of Pyrazole Derivatives Mediated by Cadmium(II) Acetate

ChemistryOpen
The present study focuses on the iodination of pyrazoles mediated by cadmium (II) acetate. The objects of research were compounds with pyrazole rings substituted by N‐propargyl, C, N‐alkyl groups.
Dr. Nina G. Hobosyan, Dr. Kristine V. Balyan, Lusine A. Movsisyan, Dr. Varduhi S. Hovsepyan, Armen G. Ayvazyan, Dr. Henrik A. Panosyan, Prof. Dr. Hovhannes S. Attaryan, Dr. Hmayak B. Sargsyan, Haykanush R. Pogosyan   +8 more
doaj   +1 more source

Structural Requirements for the Inhibition of Calcium Mobilization and Mast Cell Activation by the Pyrazole Derivative BTP2

International Journal of Biochemistry and Cell Biology, 2011
Mast cells play a critical role in the development of the allergic response. Upon activation by allergens and IgE via the high affinity receptor for IgE (FcεRI), these cells release histamine and other functional mediators that initiate and propagate ...
Mankit Law, J. Morales, L. Mottram, Archana Iyer, Blake R. Peterson, A. August   +5 more
semanticscholar   +1 more source

Lewis Acid‐Catalyzed Strain‐Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole‐Fused Aza‐Bicyclo[3.1.1]Heptanes

Advanced Science, EarlyView.
Bicyclo[1.1.0]butanes undergo a Lewis acid‐catalyzed formal (3 + 3) annulation with indolyl alcohols to furnish indole‐fused aza‐bicyclo[3.1.1]heptanes. Strain‐release‐driven C‐C bond formation, followed by C‐N bond formation via ring expansion, enables the rapid assembly of rigid, sp3‐rich bicyclic architectures under mild reaction conditions ...
Mainak Dey, Tuhin Subhra Das Mahapatra, Pragya Sharma, Manoj V. Mane, Chinmoy Kumar Hazra   +4 more
wiley   +1 more source

Image_2_PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer.tif

, 2022
As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Kwan-Young Jung (1621513), Jiyeon Ahn (624498), Ah-Young Kim (531209), Kyu Myung Lee (6185675), Sangwook Wu (8352264), Suk Joon Cho (12314645), Young-Ju Kwon (3445073), Jae-Sung Kim (605888), Navin Pandit (12314642), Jeong Su Oh (2802904), Minsung Kang (6458120)   +10 more
core   +1 more source

Characterization of Stable Pyrazole Derivatives of Curcumin with Improved Cytotoxicity on Osteosarcoma Cell Lines

Life, 2023
Curcumin (CUR) is a natural molecule that is unstable due to the presence of a bis-ketone. To obtain more stable derivatives in biological fluids, the bis-ketone was replaced with pyrazole or O-substituted oximes.
Giordana Feriotto, Riccardo Rondanin, Paolo Marchetti, Federico Tagliati, Simone Beninati, Claudio Tabolacci, Elisa Grusi, Serena Aguzzi, Carlo Mischiati   +8 more
doaj   +1 more source

Pyrene-linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights. [PDF]

Smart Mol
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Kasundra DV, Patel PN.
europepmc   +2 more sources

Data_Sheet_2_Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease.PDF

, 2022
Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides ...
Junhuai Zu (11897600), Guangyu Qin (11897597), Jun Yang (2084), Yihui Ma (10522205), Dangwei Yang (11897594)   +4 more
core   +1 more source