Results 21 to 30 of about 1,937,826 (232)

tert-Butyl 4-{[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}piperazine-1-carboxylate

Acta Crystallographica Section E, 2010
In the title pyrazole derivative, C25H26ClFN4O3, both benzene rings are twisted out of the plane through the pyrazole ring, with dihedral angles of 67.62 (10) and 27.63 (10)° for the fluoro- and chloro-substituted rings ...
Seik Weng Ng, S. Sarveswari, V. Vijayakumar, R. Venkat Ragavan, Edward R. T. Tiekink   +4 more
doaj   +1 more source

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB₁/CB₂ Receptor Interaction

Molecules, 2021
Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such properties include analgesic activity, bodyweight reduction, the antiemetic effect, the reduction of ...
Battistina Asproni, Gabriele Murineddu, Paola Corona, Gérard A. Pinna   +3 more
doaj   +1 more source

Regioselective synthesis of some new pyrazole and isoxazole derivatives incorporating benzothiazole moiety: Experimental and theoretical studies

, 2023
Nitrile imine derivative 3 added regioselectively to α-(benzothiazol-2-yl)cinnamonitrile derivatives 1a–c to afford 5-(benzothiazol-2-yl)-5-cyano-4,5-dihydro-1H-pyrazole derivatives 4a–c.
Ahmad M. Farag (16819147), Hissana Ather (12463146), Naglaa S. Mahmoud (16819144), Ahmed M. El Defrawy (16869598), Nabila A. Kheder (8888363)   +4 more
core   +1 more source

The Electrochemical Behavior of Al Alloys in NaCl Solution in the Presence of Pyrazole Derivative [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
This paper studies the corrosion inhibition of Al-Mg alloy system in 0.5 mol/dm3 NaCl solution in the presence of pyrazole derivative using potentiodynamic polarization and linear polarization method.
Veselinka Grudic, Ivana Boskovic, Dragan Radonjic, Zeljko Jacimovic, Bojana Knezevic   +4 more
doaj  

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Labelling of a pyrazole derivative substance with I-131 and investigation of its radiopharmaceutical potantial [PDF]

, 2010
Tıpta, pirazol türevi bileşikler değişik amaçlar için kullanılmaktadır.4-benzoil-1-(4-karboksifenil)-5-fenil-1H-pirazol-3-karboksilik asit'in (pirazol türevi) 131I ile işaretlenerek radyofarmasötik potansiyelini incelemektir. İyodo pirazol türevi bileşik
Kurtdede, Esra
core   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Synthesis, Characterization and ِAntimicrobial Activities of Some New Heterocyclic Schiff Bases Derived from Thiocarbohydrazide

Acta Chimica Slovenica, 2016
The reaction of prazolobenzothienopyrimidine-3-carbaldehyde 1 with thiocarbohydrazide afforded the Schiff’s base 3. The latter compound reacted with some electrophilic reagents to give 1,2,4-triazoles 4–6 and 1,2,4-triazines 7–9.
Kamelia El-mahdy, Azza El-Kazak, Mohamed Abdel-Megid, Magdy Seada, Osama Farouk   +4 more
doaj   +1 more source

Regeneration‐Optimized Chemisorbents: Evaluating Hybrid Coordination Networks for Atmospheric Water Harvesting

Angewandte Chemie, EarlyView.
Atmospheric water harvesting (AWH) under arid conditions requires desiccants that load water below 30% RH and regenerate below 60°C, a performance regime traditionally limited to physisorbents. Here, we show that the inherent hydrolytic instability of M′FSIX‐25‐M coordination networks enable regeneration‐optimized chemisorbents (ROCs) with projected ...
Xiang‐Jing Kong, Asif Raza, Lilia Croitor, Andrey Bezrukov, Xia Li, Angela Shipman, William Morris, Carlos J. Solanilla‐Salinas, Adam Hogan, Brian Space, Volodymyr Bon, Stefan Kaskel, Soumya Mukherjee, Alan C. Eaby, Tao He, Michael J. Zaworotko   +15 more
wiley   +2 more sources

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES OF FLURBIPROFEN

Zagazig Journal of Pharmaceutical Sciences, 1998
The synthesis of some novel non- carboxylic heterocyclic derivatives of flurbiprofen such as pyrazole , pyrrole , oxadiazole, oxadiazines, and triazoles, is described. Structure of the new compounds was elucidated by spectroscopic data and microanalysis.
Mohamed El-Sadek , Lobna Abdel-Aziz , Mansour Abou-Kull , Kamel Metwally   +3 more
doaj   +1 more source