Results 21 to 30 of about 15,779 (274)
On the Interactions of Fused Pyrazole Derivative with Selected Amino Acids: DFT Calculations
Journal of Chemistry, 2017 Due to the increasing prevalence of neoplasms, there is a permanent need for new selective cytostatic compounds. Anticancer drugs can act in different ways, affecting protein expression and synthesis, including disruption of signaling pathways within ...
Kornelia Czaja +7 more
doaj +1 more source
Acta Chimica Slovenica, 2016 The reaction of prazolobenzothienopyrimidine-3-carbaldehyde 1 with thiocarbohydrazide afforded the Schiff’s base 3. The latter compound reacted with some electrophilic reagents to give 1,2,4-triazoles 4–6 and 1,2,4-triazines 7–9.
Kamelia El-mahdy +4 more
doaj +1 more source
Crystal structure of [1-(3-chlorophenyl)- 5-hydroxy-3-methyl-1H-pyrazol-4-yl](p-tolyl) methanone [PDF]
, 2015 RK acknowledges the Department of Science & Technology for the single-crystal X-ray diffractometer sanctioned as a National Facility under Project No.
Gupta, V.K. +4 more
core +1 more source
, 1939 An indolylpyrazolone derivative has been synthesised The syntheses of some pyrrolapyrazole and dipyrazole derivatives have been described.
TEJENDRA NATH GHOSH, DEBABRATA DAS-GUPTA
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Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT. [PDF]
, 2018 FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML.
Bharate, Jaideep B +8 more
core +2 more sources
Machine Learning Accelerates Crystallization for Structure Determination
Angewandte Chemie, EarlyView.Single‐crystal X‐ray diffraction (SCXRD) is often constrained by the difficulty of obtaining suitable crystals. Here, a machine learning‐accelerated co‐crystal discovery workflow is established for a crystalline mate strategy that achieves over 95% prediction accuracy and experimentally delivers 114 co‐crystals from 120 candidates.
Cui‐Zhou Luan +10 more
wiley +2 more sources
SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES OF FLURBIPROFEN
Zagazig Journal of Pharmaceutical Sciences, 1998 The synthesis of some novel non- carboxylic heterocyclic derivatives of flurbiprofen such as pyrazole , pyrrole , oxadiazole, oxadiazines, and triazoles, is described. Structure of the new compounds was elucidated by spectroscopic data and microanalysis.
Mohamed El-Sadek +3 more
doaj +1 more source
Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. [PDF]
, 2020 In vivo compatible reactions have a broad range of possible applications in chemical biology and the pharmaceutical sciences. Here we report tetrazines that can be removed by exposure to isonitriles under very mild conditions.
Eckvahl, Hannah J +7 more
core
Small molecule induced reactivation of mutant p53 in cancer cells [PDF]
, 2013 The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams +58 more
core +2 more sources
New “Green” Approaches to the Synthesis of Pyrazole Derivatives [PDF]
Molecules, 2007 A novel approach to the synthesis of pyrazole derivatives from tosylhydrazones of α,β-unsaturated carbonyl compounds possessing a β-hydrogen is proposed, exploiting microwave (MW) activation coupled with solvent free reaction conditions. The cycloaddition was studied on three ketones (trans-4-phenyl-3-buten-2-one, β-ionone and trans-chalcone).
CORRADI, Anna +7 more
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