Results 71 to 80 of about 1,937,826 (232)

Experimental and Computational Interaction Studies of (E)-N’-Benzylidene-5-Methyl-1H-Pyrazole-3-Carbohydrazide with α-Glucosidase and α-Amylase Enzymes: A Detailed Structural, Spectroscopic, and Biophysical Study

, 2022
Herein we report the synthesis, DFT calculations, and molecular docking studies of a pyrazole derivative, (E)-N'-benzylidene-5-methyl-1H-pyrazole-3-carbohydrazide (E-BMPC) as α-glucosidase and α-amylase inhibitor.
My El Abbes Faouzi (3714793), Yusuf Atalay (12069908), M’hammed Ansar (12069911), Ömer Tamer (12069899), Hazem A. Ghabbour (3823627), Khalid Karrouchi (6007748), Adil Başoğlu (12069905), Saad Fettach (10591949), Smaail Radi (2284504), Davut Avcı (12069902), Yahia N. Mabkhot (8888372)   +10 more
core   +1 more source

New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.

Marine Drugs, 2017
Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella.
Amin Mokhlesi, Rudolf Hartmann, Tibor Kurtán, Horst Weber, Wenhan Lin, Chaidir Chaidir, Werner E. G. Müller, Georgios Daletos, Peter Proksch   +8 more
doaj   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Regioselective Enzyme-catalyzed Synthesis of Pyrazole-containing Podands

, 2023
Initial results are described about a new synthesis of a family of the acylic cation-complexing compounds named podands containing a pyrazole moiety as a part of the molecule.
Navarro Torres, Pilar, Conde, Santiago, Flerros, Marta, Rodríguez-Franco, María Isabel   +3 more
core   +1 more source

1,2-Bis(boronate) Arenes by Borylation Directed Borylation. [PDF]

Angew Chem Int Ed Engl
Boron electrophiles derived from tetrabromo‐pyrazaboles and AlCl3 affect the regioselective vicinal double C–H borylation of a range of arenes and polycyclic aromatic hydrocarbons (PAHs). A subsequent pinacol installation step then affords the vicinal bis‐boronate ester‐substituted arene/PAH.
Schellbach AV, Cross MJ, Noone E, Anstöter CS, Ingleson MJ.   +4 more
europepmc   +3 more sources

Crystal structure of ethyl 4-[(1H-pyrazol-1-yl)methyl]benzoate

Acta Crystallographica Section E, 2014
In the title molecule, C13H14N2O2, the dihedral angle between the pyrazole and benzene ring mean planes is 76.06 (11)°, and the conformation of the ethyl side chain is anti [C—O—C—C = −175.4 (3)°].
Ju-Xian Wang, Chao Feng
doaj   +1 more source

C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins

Chemistry – A European Journal, EarlyView.
C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens, Mark Lambers, Romano V. A. Orru, Jordy M. Saya   +3 more
wiley   +1 more source

Potent Inhibition of Ca2+ Release-activated Ca2+ Channels and T-lymphocyte Activation by the Pyrazole Derivative BTP2*

Journal of Biological Chemistry, 2004
Ca2+ entry through store-operated Ca2+ release-activated Ca2+ (CRAC) channels is essential for T-cell activation and proliferation. Recently, it has been shown that 3,5-bistrifluoromethyl pyrazole (BTP) derivatives are specific inhibitors of Ca2 ...
C. Zitt, Bettina Strauss, Eva C. Schwarz, N. Spaeth, G. Rast, A. Hatzelmann, M. Hoth   +6 more
semanticscholar   +1 more source

Sustainable Hydrogen Production by Glycerol and Monosaccharides Catalytic Acceptorless Dehydrogenation (AD) in Homogeneous Phase

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Sustainable hydrogen production can be obtained from hydogen‐rich biomass‐derived organic molecules through Acceptorless Dehydrogenation (AD) reactions. Glycerol and sugars are available in large quantities from industry and can be successfully used as substrates in AD protocols, in the presence of tailored, selective, easily tunable and thermally ...
Sylwia Kostera, Luca Gonsalvi
wiley   +1 more source

Synthesis and therapeutic evaluation of isatin-linked pyrazole motif derivatives

Multi-target drugs possess significant therapeutic potential for the therapy of complex diseases and drug-resistant conditions. Based on this fact, isatin-pyrazole derivatives, namely, 5-substituted isatin-pyrazole derivatives 7a-d and N-alkyl isatin ...
Hamad M. Alkahtani, Mashooq A. Bhat, Hazem A. Ghabbour, Ahmed M. Naglah, Mohamed A. Al-Omar, Ashraf S. Hassan, Abdulrahman A. Almehizia, Wael M. Aboulthana   +7 more
core   +1 more source