Results 71 to 80 of about 15,610 (266)

New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.

Marine Drugs, 2017
Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella.
Amin Mokhlesi, Rudolf Hartmann, Tibor Kurtán, Horst Weber, Wenhan Lin, Chaidir Chaidir, Werner E. G. Müller, Georgios Daletos, Peter Proksch   +8 more
doaj   +1 more source

Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]

, 2019
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam, Alina Secrieru, Alkorta, Andes, Anwar, Behr, Brown, Castillo, Catalan, Chauhan, Clark, Elguero, Elnagdi, Favre, Fichez, Hall, Horta, Katritzky, Katritzky, Kost, Kumar, Larina, Maria Lurdes Santos Cristiano, Mert, Minkin, Minkin, Mohamed, Nagy, Nimbalkar, Paul Michael O’Neill, Schofield, Simons, Szajda, Taylor, Zerbi   +34 more
core   +2 more sources

Crystal structure of ethyl 4-[(1H-pyrazol-1-yl)methyl]benzoate

Acta Crystallographica Section E, 2014
In the title molecule, C13H14N2O2, the dihedral angle between the pyrazole and benzene ring mean planes is 76.06 (11)°, and the conformation of the ethyl side chain is anti [C—O—C—C = −175.4 (3)°].
Ju-Xian Wang, Chao Feng
doaj   +1 more source

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Frontiers in Physiology, 2018
The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications.
Neidiane R. Trindade, Paulo R. Lopes, Lara M. Naves, James O. Fajemiroye, Pedro H. Alves, Nathalia O. Amaral, Luciano M. Lião, Ana C. S. Rebelo, Carlos H. Castro, Valdir A. Braga, Ricardo Menegatti, Gustavo R. Pedrino   +11 more
doaj   +1 more source

Synthesis, DFT, Molecular docking Analysis and Antibacterial, Antioxidant Activities of tri-substituted pyrazoles

ASM Science Journal, 2021
Pyrazole and its derivatives are contemplated crucial compounds in heterocyclic chemistry which are also used extensively in organic synthesis. These cycles are known for their biological and pharmacological activities.
Golea Lynda
doaj   +1 more source

Discovery of orexant and anorexant agents with indazole scaffold endowed with peripheral antiedema activity [PDF]

, 2019
CB1 receptors and endocannabinoids are integrated components of neuronal networks controlling different organism’s functions, such as appetite and food intake in the hypothalamus.
Dimmito, Marilisa P., Dvorácskó, Szabolcs, MINOSI, PAOLA, MOLLICA, Adriano, PIERETTI, Stefano, Stefanucci, Azzurra, Tömböly, Csaba, Zengin, Gokhan   +7 more
core   +2 more sources

Two tautomers in the same crystal: 3-(4-fluorophenyl)-1H-pyrazole and 5-(4-fluorophenyl)-1H-pyrazole

Acta Crystallographica Section E, 2014
The title co-crystal, 3-(4-fluorophenyl)-1H-pyrazole–5-(4-fluorophenyl)-1H-pyrazole (1/1), C9H7FN2, crystallizes with four independent molecules (A, B, C and D) in the asymmetric unit exhibiting two tautomeric forms (A and D; B and C) due to N—H proton ...
Thammarse S. Yamuna, Manpreet Kaur, Jerry P. Jasinski, Brian J. Anderson, H. S. Yathirajan   +4 more
doaj   +1 more source

Aziridination of a Single Carbon Atom in Alkenes via Energy Transfer Catalysis

Angewandte Chemie International Edition, EarlyView.
Contrary to traditional alkene aziridination via (formal) nitrene transfer, we herein report a strategy that achieves intermolecular aziridination of a single alkene carbon atom and installs an additional group at the other. Enabled by metal‐free energy transfer (EnT) catalysis, alkenyl boronates and silanes are transformed into reactive intermediates ...
Fritz Paulus, Corinna Heusel, Felix H. Wessels, Bünyamin Sikora, Maik G. Niedziella, Kilian van der Beck, Constantin G. Daniliuc, Frank Glorius   +7 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Rhodium(I)-N-heterocyclic carbene catalyst for selective coupling of N-vinylpyrazoles with alkynes via C-H activation [PDF]

, 2016
The complex [Rh(μ-Cl)(IPr)(η2-coe)]2 {IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-carbene, coe = cis-cyclooctene} efficiently catalyzes the coupling of alkynes and N-vinylpyrazole via C–H activation, leading to Markovnikov-selective butadienylpyrazole
Azpíroz, Ramón, Castarlenas, Ricardo, Giuseppe, Andrea di, Lahoz, Fernando J., Oro, Luis A., Passarelli, Vincenzo, Pérez-Torrente, Jesús J., Rubio-Pérez, Laura   +7 more
core   +1 more source