Results 91 to 100 of about 1,937,826 (232)

Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones

European Journal of Organic Chemistry, EarlyView.
Straightforward access to complex ketones in a single synthetic step: This Review surveys the latest advances in three‐component alkene 1,2‐oxo‐functionalizations. The opportunities unlocked by the so‐called single‐electron (1e–) logic, including access to a broad pool of radical precursors and carbonyl oxygen atom sources, are highlighted.
Mattia Lepori, Luigi Dolcini, Alexander Bell, Joshua P. Barham   +3 more
wiley   +1 more source

Ethyl 5-amino-1-(4-chloro-2-nitrophenyl)-1H-pyrazole-4-carboxylate [PDF]

, 2009
Ethyl 5-amino-1-(4-chloro-2-nitrophenyl)-1H-pyrazole-4 ...
Muhammad Zia-ur-Rehman (7162790), Muhammad Fasih Ullah (7163192), Mark Elsegood (1249893), Jamil Anwar Choudary (7163189), Hamid Latif Siddiqui (7162796)   +4 more
core   +3 more sources

Tandem Synthesis and Photophysical Behavior of Pyrazolo[3,4‐h][1,6]naphthyridines: A Theoretical–Experimental Approach

European Journal of Organic Chemistry, EarlyView.
A tandem reaction of 5‐aroylpyrazolo[3,4‐b]pyridines with malononitrile and methanol to access pyrazolo[3,4‐h][1,6]naphthyridines was achieved in 60%–66% yield under microwave conditions. The tricyclic fluorophoric core bears groups of different stereoelectronic nature (i.e., alkyl, aryl, MeO, and CN), and thus their optoelectronic activity shows ...
Carlos Cifuentes, Alexander Ladino‐Bejarano, Cristian Rivera‐Moyano, Jaime Portilla   +3 more
wiley   +1 more source

Synthesis and some reactions of 4-benzoyl-5-phenyl-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid

, 2004
The 1H-pyrazole-3-carboxylic acid 2, obtained from the furandione 1 and 2-hydrazinopyridine, was decarboxylated to give 4-benzoyl-5-phenyl-1-pyridin-2-yl-pyrazole derivative 3.
Sener, MK, ŞENER, Muhammet Kasım, Akbas, E   +2 more
core   +2 more sources

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies

Future Journal of Pharmaceutical Sciences
Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer.
Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla   +3 more
doaj   +1 more source

The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo. [PDF]

Cancer Cell Int, 2023
Gimła M, Pyrczak-Felczykowska A, Malinowska M, Hać A, Narajczyk M, Bylińska I, Reekie TA, Herman-Antosiewicz A.   +7 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

The synthesis and evaluation of 3-benzoylbenzofurans and their pyrazole derivatives against HIV-1 infections and cancer

International Journal of Infectious Diseases
Introduction: The human immunodeficiency virus-1 (HIV-1) remains one of the leading global epidemics in the world. The HIV/AIDS epidemic is particularly dominant in Eastern and Southern Africa, as is evident by the 670 000 annual new infections in this ...
Ms Sinothile Khuzwayo, Dr Mamoalosi A Selepe, Prof. Debra Mayer, Dr Ntombenhle Hlengiwe Gama   +3 more
doaj   +1 more source

Synthesis of fluorescently labeled pyrazole derivative induceing a triple response in Arabidopsis seedlings. [PDF]

J Pestic Sci, 2022
Oh K, Jiang K.
europepmc   +1 more source