Results 101 to 110 of about 15,779 (274)

Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies

Future Journal of Pharmaceutical Sciences
Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer.
Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla   +3 more
doaj   +1 more source

Dichlorido{N,N,N′-trimethyl-N′-(1H-pyrazol-1-yl-κN2)methyl]ethane-1,2-diamine-κ2N,N′}copper(II) methanol monosolvate

IUCrData, 2019
In the title compound, [CuCl2(C9H18N4)]·CH3OH, the central CuII ion is coordinated by three N atoms from the pyrazole derivative ligand and two chloride co-ligands. The coordination geometry around the CuII ion is distorted trigonal–bipyramidal.
Ravindra Singh, Akram Ali, Md. Serajul Haque Faizi, Roona Singh, Turganbay S. Iskenderov, Necmi Dege   +5 more
doaj   +1 more source

An Approach towards the synthesis of furo[3,4-c]pyrazole [PDF]

, 2009
Synthesis of pyrazole and its N-aryl analogues has been a subject of consistent interest because of the wide applications of such heterocycles in pharmaceutical as well as in agrochemical industry.
Sahoo, Krushna Chandra
core  

Rapid Discovery of Pyrido[3,4- d ]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach [PDF]

, 2016
Monopolar spindle 1 (MPS1) plays a central role in the transition of cells from metaphase to anaphase and is one of the main components of the spindle assembly checkpoint.
Baker, R, Blagg, J, Box, G, Burke, R, Cronin, N, De Haven Brandon, A, Eccles, SA, Faisal, A, Hayes, A, Henley, AT, Hoelder, S, Innocenti, P, Linardopoulos, S, Mak, GW-Y, Matijssen, B, Naud, S, O’Fee, L, Raynaud, FI, Roberts, J, Saville, H, Schmitt, J, Solanki, S, Valenti, M, van Montfort, RLM, Westwood, IM, Woodward, HL   +25 more
core   +2 more sources

The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo. [PDF]

Cancer Cell Int, 2023
Gimła M, Pyrczak-Felczykowska A, Malinowska M, Hać A, Narajczyk M, Bylińska I, Reekie TA, Herman-Antosiewicz A.   +7 more
europepmc   +1 more source

Synthesis of Pyrazole Derivatives A Review

International Journal For Multidisciplinary Research
This review deals with various method of synthesis of pyrazole derivatives the pyrazole derivatives have numerous pharmacological activities from few decades pyrazole molecule synthesis has became an important strategy for development of drug like substances.
openaire   +1 more source

Gold(I)‐Mediated Reactivity of Allenes With Mesoionic Nucleophiles: A Computational Exploration

European Journal of Organic Chemistry, EarlyView.
The regioselective gold(I)‐mediated reactivity of allenes with mesoionic nucleophiles has been evaluated through computational analysis of the mechanisms involved. Instead of typical (3 + 2) pathways, sydnones and münchnones favour the formal (3 + 3) cyclizations affording substituted dihydropyridines.
Eduardo Garcia‐Padilla, Feliu Maseras
wiley   +1 more source

The synthesis and evaluation of 3-benzoylbenzofurans and their pyrazole derivatives against HIV-1 infections and cancer

International Journal of Infectious Diseases
Introduction: The human immunodeficiency virus-1 (HIV-1) remains one of the leading global epidemics in the world. The HIV/AIDS epidemic is particularly dominant in Eastern and Southern Africa, as is evident by the 670 000 annual new infections in this ...
Ms Sinothile Khuzwayo, Dr Mamoalosi A Selepe, Prof. Debra Mayer, Dr Ntombenhle Hlengiwe Gama   +3 more
doaj   +1 more source

Crystal structure of 6-amino-4-(3-bromo-4-methoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile dimethyl sulfoxide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the pyrazole molecule of the title solvate, C15H13BrN4O2·C2H6OS, the dihedral angle between the benzene ring and the mean plane of the dihydropyrano[2,3-c]pyrazole ring system [r.m.s deviation = 0.031 (2) Å] is 86.71 (14)°.
Sammer Yousuf, Huma Bano, Munira Taj Muhammad, Khalid Mohammed Khan   +3 more
doaj   +1 more source

The therapeutic aspects of the endocannabinoid system (ECS) for cancer and their development: from nature to laboratory [PDF]

, 2016
The endocannabinoid system (ECS) is a group of neuromodulatory lipids and their receptors, which are widely distributed in mammalian tissues. ECS regulates various cardiovascular, nervous, and immune system functions inside cells.
Botta, Bruno, Czarnecka, Anna M., Khan, Mohammed I., Król, Magdalena, Sobocińska, Anna A., Szczylik, Cezary   +5 more
core   +1 more source