Results 101 to 110 of about 1,937,826 (232)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Dichlorido{N,N,N′-trimethyl-N′-(1H-pyrazol-1-yl-κN2)methyl]ethane-1,2-diamine-κ2N,N′}copper(II) methanol monosolvate

IUCrData, 2019
In the title compound, [CuCl2(C9H18N4)]·CH3OH, the central CuII ion is coordinated by three N atoms from the pyrazole derivative ligand and two chloride co-ligands. The coordination geometry around the CuII ion is distorted trigonal–bipyramidal.
Ravindra Singh, Akram Ali, Md. Serajul Haque Faizi, Roona Singh, Turganbay S. Iskenderov, Necmi Dege   +5 more
doaj   +1 more source

Experimental and Theoretical Tests on the Corrosion Protection of Mild Steel in Hydrochloric Acid Environment by the Use of Pyrazole Derivative. [PDF]

Materials (Basel), 2023
Boudalia M, Fernández-Domene RM, Guo L, Echihi S, Belghiti ME, Zarrouk A, Zarrouk A, Bellaouchou A, Guenbour A, García-Antón J.   +9 more
europepmc   +1 more source

Band Engineering of Benzothiadiazole‐Derived Metal‐Organic Frameworks for Photocatalytic Organic Transformations

National Materials, EarlyView.
BTID‐functionalized metal‐organic frameworks provide a modular platform for tailoring photocatalytic electronic structures through acceptor‐linker engineering. By correlating band alignment, charge‐transfer characteristics, and reactive oxygen species generation, this review highlights design principles that enable efficient visible‐light‐driven ...
Xin Li, Long‐Shuang Chen, Meng‐Hao Li, Ying‐Wei Yang   +3 more
wiley   +1 more source

Enhanced Antibacterial Activity of a Cationic Macromolecule by Its Complexation with a Weakly Active Pyrazole Derivative. [PDF]

Biomedicines, 2022
Schito AM, Caviglia D, Brullo C, Zorzoli A, Marimpietri D, Alfei S.   +5 more
europepmc   +1 more source

Discovery and characterisation of succinate dehydrogenase inhibitor resistance in Plenodomus biglobosus (phoma stem canker of oilseed rape)

Pest Management Science, EarlyView.
SDHI resistance is reported and characterised for the first time in the oilseed rape phoma stem canker pathogen Plenodomus biglobosus (Leptosphaeria biglobosa). We investigate cross‐resistance patterns, associated SDH target‐site mutations, possible fitness costs, and consider the implications for disease and resistance management.
Kevin M King, Jonathan S West
wiley   +1 more source

N-{2-[2-(5-Methyl-1H-pyrazol-3-yl)acetamido]phenyl}benzamide monohydrate

IUCrData, 2017
The asymmetric unit of the title compound, C19H18N4O2·H2O, comprises the U-shaped pyrazole derivative and a solvent water molecule. The molecular conformation is partly determined by an intramolecular N—H...O hydrogen bond.
Karim Chkirate, Joel T. Mague, Nada Kheira Sebbar, Younes Ouzidan, El Mokhtar Essassi   +4 more
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

Molecules, 2013
In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules.
Giorgio Chelucci, Gérard A. Pinna, Giovanni Loriga, Giansalvo Pinna   +3 more
doaj   +1 more source

Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro. [PDF]

Biology (Basel), 2022
Hess JD, Macias LH, Gutierrez DA, Moran-Santibanez K, Contreras L, Medina S, Villanueva PJ, Kirken RA, Varela-Ramirez A, Penichet ML, Aguilera RJ.   +10 more
europepmc   +1 more source