Results 121 to 130 of about 15,610 (266)

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Xanthohumol Pyrazole Derivative Improves Diet-Induced Obesity and Induces Energy Expenditure in High-Fat Diet-Fed Mice. [PDF]

ACS Pharmacol Transl Sci, 2021
Paraiso IL, Mattio LM, Alcázar Magaña A, Choi J, Plagmann LS, Redick MA, Miranda CL, Maier CS, Dallavalle S, Kioussi C, Blakemore PR, Stevens JF.   +11 more
europepmc   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

The Effect of Nano-Pyrazole Derivative of Thiosemicarbazone Magnetite on BRCA1, p53 and Bcl-2 Gene Expression in MCF-7 Breast Cancer Cell Line

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Breast cancer is one of the most important causes of cancer deaths especially in developing countries. However, some synthetic compounds such as thiosemicarbazone and its metal derivatives can play a very significant role in ...
Mohammad Reza Izadpanah, Ali Saleh zadeh, Mohammad Zaiefi zadeh, Mohammad Nik pasand   +3 more
doaj  

Chan–Lam Cross‐Coupling With Alkylboron Reagents: From Transmetallation to Radical Pathways

European Journal of Organic Chemistry, EarlyView.
Alkylative Chan–Lam coupling overcomes intrinsic transmetallation limitations of alkylboron reagents by engaging radical pathways. Recent advances reveal how radical and radical–polar crossover mechanisms enable mild C(sp3)—heteroatom bond formation. This minireview highlights key mechanistic insights and emerging strategies that transform alkylboron ...
Nicolas G.‐Simonian, Andrea Serafino, Luc Neuville, Géraldine Masson   +3 more
wiley   +1 more source

Synthesis and Anti-Trypanosoma cruzi Activity of New Pyrazole-Thiadiazole Scaffolds

Molecules
Chagas disease, a silent but widespread disease that mainly affects a socioeconomically vulnerable population, lacks innovative safe drug therapy. The available drugs, benznidazole and nifurtimox, are more than fifty years old, have limited efficacy, and
Thamyris Perez de Souza, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Vitoria Barbosa Paes, Lucas Penha Dutra, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira   +6 more
doaj   +1 more source

Photochemical Decatungstate‐Catalyzed Hydroacylation of Maleimides

European Journal of Organic Chemistry, EarlyView.
A photocatalytic protocol to access substituted succinimides via tetra‐n‐butylammonium decatungstate photocatalysis is reported. This direct radical‐driven hydroacylation of a variety of N‐substituted maleimides shows tolerance to various aldehydes (or alkanes), affording differentially substituted succinimides in high yields. Succinimides constitute a
Manos V. G. Lantzanakis, Naya A. Stini, Christoforos G. Kokotos   +2 more
wiley   +1 more source

1,2‐Diazetidines − Structure, Synthesis, and Functionalization

European Journal of Organic Chemistry, EarlyView.
1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley   +1 more source

Designing and Synthesis of Novel Celecoxib Derivatives with Aminosulfonylmethyl and Azidomethyl Substituents as Selective Cyclooxygenase-2 Inhibitors [PDF]

, 2014
: Introduction: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are used in treating pathologic conditions such as fever, pain and inflammation by inhibiting cyclooxygenase and consequently prostaglandin production.
Ebrahimabadi A.H., Irannejad H.,
core  

Isoreticular Metal–Covalent Organic Frameworks With Engineered π‐Conjugation for Efficient Photocatalytic Hydrogen Production

Electron, EarlyView.
By constructing an isoreticular Cu3‐cluster‐based metal–covalent organic framework platform with systematically tunable π‐conjugation, the physicochemical properties can be finely modulated within a well‐defined structural framework, thereby establishing a precise conjugation–performance correlation to govern the charge separation/transport, and thus ...
Yu‐Qi Zhang, Jiao Tan, Hui‐Li Zheng, Jian‐Qiang Zhao, Zhouyu Jiang, Jie Chen, Dong‐Dong Ma, Xiaofang Li, Qi‐Long Zhu   +8 more
wiley   +1 more source