Molecules, 2013 In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules.
Giorgio Chelucci +3 more
doaj +1 more source
A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process. [PDF]
, 2015 A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated ...
Browne, Duncan L +2 more
core +5 more sources
Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro. [PDF]
Biology (Basel), 2022 Hess JD +10 more
europepmc +1 more source
The Chemical Record, EarlyView.This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros +5 more
wiley +1 more source
Towards Hybrid Density Functional Calculations of Molecular Crystals via Fragment-Based Methods
, 2018 We introduce and employ two QM:QM schemes (a quantum mechanical method embedded into another quantum mechanical method) and report their performance for the X23 set of molecular crystals.
Boese, A. Daniel +2 more
core +1 more source
Key Intermediates: A simple and Highly Selective Synthesis of 5-amino-1-aryl-1H-pyrazole-4-carbonitriles for Applications in the Crop Protection [PDF]
, 2015 A series of six pyrazoles was synthesized by Michael-type addition reaction. The molecules 5- amino-1-aryl-1H-pyrazole-4-carbonitrile (3a-f) were synthesized from (ethoxymethylene)malononitrile (1) and fluorinated and non-fluorinated aryl hydrazines (2a ...
Murguia, Marcelo Cesar +2 more
core +2 more sources
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
The Chemical Record, EarlyView.Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source
Design and Synthesis of New A2B Adenosine Receptor Antagonists [PDF]
, 2009 Starting from chemical structure of N-benzo-[1,3]dioxol-5-yl-2-[5-(2,6dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol3-yloxy]-acetamide, MRE2029F20* various structural modifications were realized to afford a new series of A2B ...
BARALDI, Stefania
core
Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative. [PDF]
Nanomaterials (Basel), 2021 Alfei S +3 more
europepmc +1 more source
Synthesis and Thermolysis of Ylidyl‐Substituted Stannylenes
Zeitschrift für anorganische und allgemeine Chemie, EarlyView.The synthesis of an amino(ylidyl)stannylene is reported. The title compound was characterized via X‐ray diffraction and features a Sn2C2 heterocycle. Thermal treatment of the stannylene leads to the elimination of the amine. The products of the thermolysis are discussed.
Pascal Weisenburger +3 more
wiley +1 more source