Results 121 to 130 of about 1,937,826 (232)

Regioselective Diversification of Aminopyrazoles via Ir‐Catalyzed C─H Borylation

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Aminopyrazoles, an important bioactive pharmacophore, are typically accessed inefficiently through de novo syntheses that yield isomeric mixtures of 3‐ and 5‐substituted derivatives. To address this challenge, we have elaborated readily available 3‐ and 5‐aminopyrazole fragments using Ir C─H borylation, regioselectively furnishing boronates for ...
Jay S. Wright, Felipe M. Nogueira, Andrew C. Hones, Mingyan Ding, Mark A. Fox, Wender A. Silva, Angelo H. de Lira Machado, Alpay Dermenci, David C. Blakemore, Patrick G. Steel   +9 more
wiley   +1 more source

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source

Synthesis and Anti-Trypanosoma cruzi Activity of New Pyrazole-Thiadiazole Scaffolds

Molecules
Chagas disease, a silent but widespread disease that mainly affects a socioeconomically vulnerable population, lacks innovative safe drug therapy. The available drugs, benznidazole and nifurtimox, are more than fifty years old, have limited efficacy, and
Thamyris Perez de Souza, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Vitoria Barbosa Paes, Lucas Penha Dutra, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira   +6 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Synthesis and crystal structures of mononuclear CuII/CoII coordination complexes from pyrazole-dicarboxylate acid derivatives

, 2015
Three novel pyrazole-dicarboxylate acid derivatives namely 1-(carboxymethyl)-5-methyl-1H-pyrazole-3-carboxylic acid [L1], 1-[(3-carboxy-5-methyl-1H-pyrazol-1-yl) methyl]-5-methyl-1H-pyrazole-3-carboxylic acid [L2] and 1-[3-(3-carboxy-5-methyl-1H-pyrazol ...
Nayarassery Narayanan, Adarsh, Ettouhami, A., Robeyns, Koen, Yahyi, A., Chaudary Jha, A., Radi, S., Garcia, Yann   +6 more
core   +1 more source

Synthesis of Heterocyclic Compounds Derived from 2-Mercapto Quinoline

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
2-Mercapto quinoline was used as precursor for synthesis of new heterocyclic derivatives of quinoline nucleus such as pyrazole (3), pyrazolone (4), 1,3,4-oxadiazole (5) and 1,2,4-triazole (8). New Schiff bases (9a-e) were obtained from the reaction of
A. H. Sharba, H. A. Hassan, D. F. Hassan
doaj  

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, Volume 82, Issue 11, Page 10615-10624, November 2026.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

, 2013
International audienceWe report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids.
Janin, Yves, Louis, Guillou, Sandrine, Ermolenko, Mikhail, S.   +2 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Facile synthesis of novel α-methylene-pyrazole-carboxylate substituted imines and trans-β-lactams: Versatile synthons for diverse heterocyclic molecules

, 2018
A simple, facile, and high yielding stereoselective approach for the integration of α-methylene-pyrazole-carboxylates at the β-lactam nucleus is described.
Aman Bhalla (3832465), Shiwani Berry (4404241), Shamsher S. Bari (3832459), Qudrat Hundal (5008523), Dipika Narula (5008526)   +4 more
core   +1 more source