Results 141 to 150 of about 1,937,826 (232)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Chiral Pyrazolinylidene Complexes for Asymmetric Catalysis

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
The synthesis and application of pyrazolin‐5‐ylidene NHC chiral‐at‐ruthenium catalysts is reported. The strong donating pyrazolin‐5‐ylidene ligands led to highly electron rich ruthenium complexes, which showed excellent catalytic activity and enantioselectivity in the intramolecular aziridination of an alkene.
Felix Möller, Nemrud Demirel, Thomas Krüger, Linus Plohnke, Jennifer Schröder, Sergei I. Ivlev, Eric Meggers   +6 more
wiley   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Studies on reactions of cyclic oxalyl compounds with hydrazines or hydrazones - 2. Synthesis and reactions of 4-benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid

, 2004
4-Benzoyl-1-(4-nitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, obtained from corresponding furan-2,3-dione and N-benzylidene-N'-(4-nitrophenyl)hydrazine, was converted via reactions of its acid chloride with various alcohols or N-nucleophiles into ...
Sener, MK, Kasimogullari, R, Sener, A, Genc, H   +3 more
core   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

Hepatoprotective potential of M3F, a benzimidazole pyrazole derivative, against paracetamol induced hepatotoxicity. [PDF]

Sci Rep
Ilyas Z, Rehman A, Nadeem H, Noman M, Noor R, Irshad N.   +5 more
europepmc   +1 more source

Indolenine-substituted pyrazole derivative 4e inhibits planktonic <i>Staphylococcus lugdunensis</i> growth and biofilm formation by disrupting purine biosynthesis and compromising cell wall and membrane integrity. [PDF]

Antimicrob Agents Chemother
Hidrosollo JH, Liao H-W, Yap CH, James JJ, Lu J-J, Tai Y-H, Wei C, Thuy TTD, Chin SP, Tay ST, Chee CF, Kao CY.   +11 more
europepmc   +1 more source

A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca2+ Influx and IL-2 Production in T Lymphocytes

Journal of Immunology, 2003
J. Ishikawa, Keiko Ohga, T. Yoshino, Ryuichi Takezawa, A. Ichikawa, H. Kubota, T. Yamada   +6 more
semanticscholar   +1 more source

Discovery of New Pyrazole-Linked Pyridine Derivatives as Multi-Target Anti-Inflammatory Agents With Immunomodulatory Potential. [PDF]

Drug Dev Res
Salem MA, Raslan RR, Gohar NA, Abusaif MS, Ammar YA, Ragab A.   +5 more
europepmc   +1 more source