Results 141 to 150 of about 340,649 (242)
N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides
Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison +6 more
wiley +2 more sources
Indolenine-substituted pyrazole derivative 4e inhibits planktonic <i>Staphylococcus lugdunensis</i> growth and biofilm formation by disrupting purine biosynthesis and compromising cell wall and membrane integrity. [PDF]
Antimicrob Agents ChemotherHidrosollo JH +11 more
europepmc +1 more source
European Journal of Soil Science, Volume 77, Issue 5, September–October 2026.ABSTRACT Long‐term integrated soil management strategies are essential for enhancing soil organic matter (SOM) quality and promoting the availability of mineralizable nitrogen (N). This study employed a tripartite analytical framework to investigate how crop rotations and organic N amendments influence soil N availability and SOM chemistry.
Sevendeep Kaur Chahal +4 more
wiley +1 more source
Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 5, Page 515-524, September 2026.ABSTRACT This study characterized the long‐term pharmacokinetic profile of a 1% fipronil pour‐on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC–MS/MS.
Stefani Maria Ferreira +8 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti +10 more
wiley +1 more source
Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo +8 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 16, 27 August 2026.Air stable bimetallic iron one‐component systems capable of CO2 cycloaddition to epoxides under 1 bar of pressure of CO2. In this work, one‐component iron catalysts for the atom‐economical reaction of CO2 with epoxides have been used as efficient catalysts for the carbon dioxide cycloaddition into cyclic carbonates in excellent yields.
María P. Caballero +10 more
wiley +1 more source
Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation
Angewandte Chemie International Edition, Volume 65, Issue 35, 24 August 2026.An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier +2 more
wiley +1 more source
Chemoselective synthesis of pyrazole derivatives via beta-enamino keto esters
, 2000 beta -Enamino keto ester (2a) reacts with hydroxylamine to give an isoxazole derivative (3). Compound (2a) reacts with hydrazine, alkyl- and arylhydrazines to give pyrazole derivatives (4a-e) as only reaction products.
C. F. Morelli +2 more
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Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes
Chemistry – A European Journal, Volume 32, Issue 32, 24 August 2026.The synthesis, functionalization, and reactivity as dipoles of 3‐aminosydnones have been investigated. These neglected compounds undergo smooth cycloaddition reactions with strained alkynes, leading to 1‐aminopyrazoles. ABSTRACT We present in this article the synthesis, functionalization, and properties of 3‐aminosydnones, a forgotten class of ...
Apolline Dominic +7 more
wiley +1 more source