Results 151 to 160 of about 15,610 (266)

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Cytotoxicity study of pyrazole derivatives

Bangladesh Journal of Pharmacology, 2007
Pyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2). Their cytotoxicity effects were measured by brine shrimp lethality bioassay. Among them the compounds 2(b),
openaire   +1 more source

ChemBang: Expanding the Chemical Space Around Small Molecules

Molecular Informatics, Volume 45, Issue 5, May 2026.
Schematic diagram of the underlying concepts behind ChemBang and the molecular generation process from a seed molecular structure by applying the three main categories of chemical transformations, namely, interchange of small substituents, replacement of ring systems, and scaffold enlargement by additional ring systems.
Diana Montes‐Grajales, Luca Menestrina, Ricard Garcia‐Serna, Jordi Mestres   +3 more
wiley   +1 more source

Pyrazole Based Inhibitors against Enzymes of Staphylococcus aureus:A Computational Study [PDF]

, 2015
Aravindhan, S., Jagadeesan, G., Krishnaswamy, Gunasekaran, Palayam, Malathy, Peters, Günther H.J., Suresh, G., Vijayakuma, Vinodhkumar   +6 more
core   +1 more source

Hybrid Modification Strategies of Metal–Organic Frameworks: A Review on Structural Design and Environmental Applications

ChemistryOpen, Volume 15, Issue 5, May 2026.
This review examines how hybrid modification strategies enhance the structural design and environmental performance of metal–organic frameworks (MOFs). It outlines key synthesis routes, functionalization approaches, and integration with complementary materials, highlighting advances in pollutant removal, sensing, and sustainable remediation.
Samar H. Elagamy, Adel M. Michael, Reem H. Obaydo, Hayam M. Lotfy   +3 more
wiley   +1 more source

Azobenzene‐Functionalized Ionic Liquids: Light‐Responsive Surfactants With Catalytic Potential

ChemistryOpen, Volume 15, Issue 5, May 2026.
Surface‐active imidazolium‐based ionic liquids containing an azobenzene group exhibit different micellization properties upon photoisomerization. Applying a sulfonate tag to the azobenzene moiety profoundly affects the physicochemical behavior of both isomers in water.
Markus Hegelmann, Stefan Frei, Julian Zuber, Johannes Luibl, Wolfgang Korth, Andreas Jess, Peter Coburger, Mirza Cokoja   +7 more
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Sustainable Oxidation of Azoles: Structure‐Reactivity Controls and Reactive Species Dynamics in UV‐Activated Persulfate Processes

ChemSusChem, Volume 19, Issue 8, 28 April 2026.
The UV‐activated persulfate process rapidly decomposes azoles, while mineralization depends on oxidant type and molecular structure. PR and TA achieve high mineralization via O2•‐ pathways, whereas BTA and 5MBTA show limited mineralization dominated by 1O2.
Heejin Yang, Ahyeon Jo, Sungju Yu, Chang‐Gu Lee, Gyu Leem   +4 more
wiley   +1 more source

Hepatoprotective potential of M3F, a benzimidazole pyrazole derivative, against paracetamol induced hepatotoxicity. [PDF]

Sci Rep
Ilyas Z, Rehman A, Nadeem H, Noman M, Noor R, Irshad N.   +5 more
europepmc   +1 more source

Porphyrin‐Geländer–Helical Conjugated Banister Type Porphyrin Dyads

Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.
Porphyrin arrays go chiral–A porphyrin Geländer macrocycle represents the intriguing prototype architecture of helically chiral butadiyne‐linked porphyrin arrays. This study combines synthetic, spectroscopic, and computational methods to shed light on its structure, chiroptical properties, and tunability, highlighting its promise for advancing ...
Joël F. Keller, Adriano D'Addio, Marcel Mayor   +2 more
wiley   +1 more source