Results 171 to 180 of about 340,649 (242)

Design and synthesis of 1,3,4-oxadiazole-tethered <i>N</i>-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and <i>in silico</i> studies. [PDF]

RSC Adv
Al-Warhi T, Islam Mukim MS, Elsayed ZM, Omar YM, Elimam DM, Shaldam MA, El-Damasy AK, Elbadawi MM, Tawfik HO, Song DG, Eldehna WM.   +10 more
europepmc   +1 more source

Exploring Novel Indazole and Pyrazole Nucleoside Analogues: Enzymatic Synthesis, Characterization, and Biological Evaluation. [PDF]

Int J Mol Sci
Mironov AF, Eletskaya BZ, Antonov KV, Paramonov AS, Esipov RS, Konstantinova ID, Andreevskaya SN, Smirnova TG, Karpenko IL, Sokhraneva VA, Zhivotova IS, Kochetkov SN, Khandazhinskaya AL, Matyugina ES.   +13 more
europepmc   +1 more source

Unlocking the Potential of Isatin Scaffolds in Acetylcholinesterase Inhibition. [PDF]

Arch Pharm (Weinheim)
Tharwat T, El-Nassan HB, Adly ME, Kamel MM.   +3 more
europepmc   +1 more source

The Pyrazole Scaffold in Anticancer Drug Discovery: A Review of Synthetic Approaches, Structure-Activity Relationships, and Target-Based Mechanism of Action. [PDF]

Int J Mol Sci
K R K, Hacholli VB, Gackowski M, Pisklak DM, Kumar A, Szeleszczuk Ł.   +5 more
europepmc   +1 more source

Design, synthesis, molecular docking and molecular dynamics simulations of pyrazolo[3,4-<i>d</i>]pyrimidine scaffolds as selective COX-2 and CDK2 kinase inhibitors with dual anti-inflammatory and anti-proliferative activities. [PDF]

RSC Adv
Ewieda SY, Ziko L, Elshewy A, Salem M, Ibrahim ML, Lotfy Khaled M, Abdalla M, Eltayb WA, Elnagar MR, Tawfik MM, Abdullah Alzahrani AY, Nemr MTM.   +11 more
europepmc   +1 more source

Discovery of a Novel 4,5-Dihydro-1<i>H</i>-pyrazole-1-carbothioamide Derivative with Cytotoxic, Apoptotic, and ABL1 Inhibitory Activities Against Chronic Myeloid Leukemia. [PDF]

Biomedicines
Erkan A, Irgit Calayir A, Ciftci H, Sever B.   +3 more
europepmc   +1 more source

Facile Synthesis of Indole-, Pyrazole-, and Indazole-Pyrrolidine Hybrids as Novel Chiral Heterocyclic Building Blocks. [PDF]

Molecules
Jankauskas R, Kleizienė N, Račkauskienė G, Bieliauskas A, Dagilienė M, Krikštolė S, Belyakov S, Sløk FA, Šačkus A.   +8 more
europepmc   +1 more source

Recent Advances in Pyrazole-Based Cholinesterase Inhibitors: Medicinal Chemistry Perspectives from 2020 to 2025. [PDF]

Pharmaceuticals (Basel)
Yeysin L, Akın D, Çalışkan S, Hasanoğlu Özkan E, Hashem H, Akocak S, Bräse S, Çete S.   +7 more
europepmc   +1 more source

Bioactive Composition and Antioxidant and Glycemic-Regulating Properties of <i>Basella alba</i> L. Leaf, Fruit, and Stem: GC-MS, FTIR, In Vitro and In Silico Insights. [PDF]

Food Sci Nutr
Das S, Rony SR, Sarkar BK, Kundu SK, Debnath P.   +4 more
europepmc   +1 more source

Solvent-free synthesis of coumarin derivatives for improved anti-corrosion and mechanical performance of primer coatings. [PDF]

Sci Rep
Abdel-Aziem A, Hussein WA, Ahmed MA, Elsawy MM.   +3 more
europepmc   +1 more source