Results 181 to 190 of about 1,937,826 (232)

Discovery of a Novel 4,5-Dihydro-1<i>H</i>-pyrazole-1-carbothioamide Derivative with Cytotoxic, Apoptotic, and ABL1 Inhibitory Activities Against Chronic Myeloid Leukemia. [PDF]

Biomedicines
Erkan A, Irgit Calayir A, Ciftci H, Sever B.   +3 more
europepmc   +1 more source

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Synthesis of and anti-fibrotic effect of pyrazole derivative J-1048: Inhibition of ALK5 as a novel approach to liver fibrosis targeting inflammation.

Bioorganic chemistry (Print), 2023
Liver fibrosis is a worldwide challenge of health issue. Developing effective new drugs for treating liver fibrosis is of great importance. In recent years, chemically synthesized drugs have significant advantages in treating liver fibrosis.
Hong-Xu Yang, Fang-Yan Guo, Yong-Ce Lin, Yan-Ling Wu, Ji-Xing Nan, C. Jin, Li-Hua Lian   +6 more
semanticscholar   +1 more source

The in vitro and in vivo study of a pyrazole derivative, J-1063, as a novel anti-liver fibrosis agent: Synthesis, biological evaluation, and mechanistic analysis.

Bioorganic chemistry (Print), 2022
In the present study, we completed the synthesis of a pyrazole derivative J-1063 and evaluated the kinase inhibitory activity of J-1063 activin receptor-like kinase 5 (ALK5) and p38α mitogen-activated protein (MAP) in the enzymatic assay.
Guangfa Zheng, Jian Liu, Fang-Yan Guo, Zhi-Hong Zhang, Yin Jiang, Yong-Ce Lin, Xiaochen Lan, Jie Ren, Yan-Ling Wu, Ji-Xing Nan, Cheng-Hua Jin, Li-Hua Lian   +11 more
semanticscholar   +1 more source

Synthesis, characterization, and biological evaluation of new chitosan derivative bearing diphenyl pyrazole moiety.

International Journal of Biological Macromolecules, 2023
This work reports the synthesis of a new pyrazole derivative by reacting 5-amino-1,3-diphenyl pyrazole with succinic anhydride and bearing the product chemically on the chitosan chains via amide linkage to achieve a new chitosan derivative (DPPS-CH). The
Ahmed G. Hamodin, Walid E. Elgammal, A. Eid, A. Ibrahim   +3 more
semanticscholar   +1 more source

Experimental and theoretical investigation of optical nonlinearities in (nitrovinyl)-1H-pyrazole derivative.

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, 2013
This work reports on the optical nonlinearities of a newly synthesized pyrazole derivative, namely (E)-1-(4-chlorophenyl)-4-(2-nitrovinyl)-1H-pyrazole.
Y. Dwivedi, L. de Boni, P. Gonçalves, L. M. Mairink, R. Menegatti, T. L. Fonseca, S. Zílio   +6 more
semanticscholar   +2 more sources

Photovoltaic Solar Cells Based on Pyrazole Derivative

Materials Letters, 2013
Ewa Gondek
exaly   +2 more sources

Nickel (II) and cobalt (II) complexes with bidentate nitrogen-sulfur donor pyrazole derivative ligands: Syntheses, characterization, X-ray structure, electrochemical studies, and antibacterial activity

, 2020
The synthesis, characterization, antibacterial activity and cyclic voltammetry of bidentate N,S donor pyrazole derivative ligands abbreviated as Na(EtNCSPz) (1), Na(PhNCSPz) (2), Na(PhNCSPzme2) (3), Na(PhNCSPzme3) (4) and their metal complexes with Ni(II)
Behzad Soltani, Monireh Ghorbanpour, C. Ziegler, Mostafa Ebadi-Nahari, R. Mohammad-Rezaei   +4 more
semanticscholar   +1 more source

Development of novel pyrazole, imidazo[1,2-b]pyrazole, and pyrazolo[1,5-a]pyrimidine derivatives as a new class of COX-2 inhibitors with immunomodulatory potential.

European journal of medicinal chemistry, 2023
Searching for new compounds with anti-inflammatory properties is a significant target since inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and pyrazolopyrimidine derivatives were designed and synthesized by reaction of 3 ...
Radwa Ayman, Moustafa S. Abusaif, A. Radwan, A. M. Elmetwally, A. Ragab   +4 more
semanticscholar   +1 more source