Results 111 to 120 of about 20,139 (226)

Ligand‐Based Pharmacophore Modeling and Structure‐Based Virtual Screening for Identifying Potential Therapeutic Agents Targeting the SARS‐CoV‐2 Spike Protein‐ACE2 Receptor Interaction

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A protocol guided by ligand‐based pharmacophore modeling and structure‐based virtual screening enabled the identification of 1H‐pyrazol‐5‐ol derivatives as novel inhibitors of the SARS‐CoV‐2 spike protein. The lead inhibitors, C‐3 and C‐4, could serve as templates for the design of potent antiviral agents targeting viral entry into host cells ...
Timoteo Delgado‐Maldonado, Gilberto Vargas‐Salas, Debasish Bandyopadhyay, Adriana Moreno‐Rodríguez, Eyra Ortiz‐Pérez, Gildardo Rivera   +5 more
wiley   +1 more source

Photochemical Decatungstate‐Catalyzed Hydroacylation of Maleimides

European Journal of Organic Chemistry, Volume 29, Issue 20, 27 May 2026.
A photocatalytic protocol to access substituted succinimides via tetra‐n‐butylammonium decatungstate photocatalysis is reported. This direct radical‐driven hydroacylation of a variety of N‐substituted maleimides shows tolerance to various aldehydes (or alkanes), affording differentially substituted succinimides in high yields. Succinimides constitute a
Manos V. G. Lantzanakis, Naya A. Stini, Christoforos G. Kokotos   +2 more
wiley   +1 more source

Unlocking the antidiabetic potential of novel pyrazole-triazole hybrids through synthesis, dual α-amylase/α-glucosidase inhibition, multiscale biological evaluation, and molecular dynamics studies. [PDF]

RSC Adv
Fakhry MM, Elkotamy MS, Elgohary MK, Alkabbani MA, Mohamed MH, Almehizia AA, Naglah AM, Fakhry MM, Fares M, Abdel-Aziz HA, Bouajila J.   +10 more
europepmc   +1 more source

A photochemical strategy for pyrazole to imidazole conversion. [PDF]

Chem Sci
Wei Y, Kasama K, Igartua A, Yildiz DB, Ceuninck A, Dos Santos T, Büttner C, Thevenet D, Bossart M, Derdau V, Méndez M, Jubault P, Poisson T, Roure B, Leonori D.   +14 more
europepmc   +1 more source

Enantioselective Pyrazole Alkylation via Iridium and Squaramide Catalyzed N-H Insertion. [PDF]

J Am Chem Soc
Ruud KJ, Antonucci AJ, Lukovic V, Vennemeyer A, Dong VM.   +4 more
europepmc   +1 more source

Ion-Electron Coupling-Driven Redox Behavior in Metal-Organic Frameworks. [PDF]

J Am Chem Soc
Avilés A, Ghotbi M, Ferguson AJ, Blackburn JL, Talin AA, Darensbourg MY, Balbuena PB.   +6 more
europepmc   +1 more source

Chemistry and Pharmacological Activities of Pyrazole and Pyrazole Derivatives: A Review

International Journal of Pharmaceutical Sciences Review and Research, 2020
Gurdeep ., Phool Chandra, Neetu Sachan
openaire   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, Volume 32, Issue 19, 22 May 2026.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Green synthesis of diazo-pyrazole derivatives and their application as functional disperse dyes for dyeing polyester fabric. [PDF]

Sci Rep
Kafafy H, Hussien AM, Sayed GH, Mashaly H, Anwer KE.   +4 more
europepmc   +1 more source