Results 111 to 120 of about 36,678 (260)

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Preparation of 5-(β-D-ribofuranosyl)pyrazole-3-carboxamide

, 1982
Synthesis of the pyrazole analogue of ribavirin (I), 5-(β-D-ribofuranosyl)pyrazole-3-carboxamide (II), is described. The compound II exhibits low virostatic activity.
Jiří Gut, Tomáš Vaněk
core   +1 more source

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, Volume 82, Issue 11, Page 10615-10624, November 2026.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

Recent biological evaluations of novel bioactive pyrazole derivatives developed between 2025 and 2026

Discover Chemistry
Pyrazoles represent a privileged heterocyclic scaffold in modern medicinal chemistry owing to their remarkable structural versatility and broad spectrum of biological activities.
Nikunj Patadiya, Vipul Vaghela
doaj   +1 more source

SYNTHESIS AND REACTIONS OF SOME 1H-PYRAZOLE-3 CARBOXYLIC ACID CHLORIDE

, 2009
The pyrazole-carboxylic acid chloride 2 was obtained from the reaction of 4-Benzoyl-1-(2,4-dinitrophenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid I and thionyl chloride.
Sarıpınar, Emin, Sevgi Zühal, İLHAN, Ilhan Özer, İhan Özer İlhan, Kökbudak, Zülbiye, SARIPINAR, Emin, ZUHAL, Sevgi, Zülbiye Önal, Onal, Zulbiye, Emin Saripinar   +9 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Pyrazole derivatives as polyethylene oxidative destruction stabilizers [PDF]

, 2012
The possibility of newly synthesized pyrazole derivatives using as heat stabilizers of high-pressure polyethylene (LDPE): 1-acetyl-4-methyl-3(5)-(2-(3-nitrophenyl)vinyl)-1H-pyrazole (additive 1) and 4benzoyl-3-(2-(4-nitrophenyl)vinyl-5-phenyl-1-tosyl-1H ...
Kuz’menok, N. M., Baulin, I. S., Yatsenko, V. V., Кoval’chuk, T. A., But’ko, T. A., Mikhalyonok, S. G., Nesterova, S. V.   +6 more
core   +1 more source

Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

British Journal of Pharmacology, Volume 183, Issue 21, Page 6501-6518, November 2026.
Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca, Patricia Raposo Afonso, Valentin Morfin, James Cantley, Jenni Harvey   +4 more
wiley   +1 more source

Copper pyrazole addition regulates soil mineral nitrogen turnover by mediating microbial traits

Frontiers in Microbiology
The huge amount of urea applied has necessitated best-developed practices to slow down the release of nitrogen (N) fertilizer while minimizing nitrate loss.
Yuming Wang, Yuming Wang, Yuming Wang, Wenling Zhong, Wenling Zhong, Wenling Zhong, Xiwen Zhang, Xiwen Zhang, Xiwen Zhang, Minghui Cao, Minghui Cao, Zheng Ni, Zheng Ni, Zheng Ni, Mengxia Zhang, Mengxia Zhang, Mengxia Zhang, Jiangye Li, Yan Duan, Yan Duan, Lifang Wu, Lifang Wu   +21 more
doaj   +1 more source

A KATing Edge Perspective on KAT6A Inhibitors as Anticancer Agents

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
This perspective efficiently summarizes the development of lysine acetyltransferase (KAT) inhibitors as anticancer agents, and the most clinically advanced KAT6A inhibitor, prifetrastat, entered Phase III clinical trials in 2025. KAT6A structural biology and structure activity relationships for acylsulfonylhydrazides, [1,2,4]thiadiazines, and ...
Rochelle Woodland, Adi Suwandi, Awgichew Behaile Teklemariam, Nidhish Francis, Li Li, Kenneth A. Chinkwo, Jonathan B. Baell, David J. Leaver   +7 more
wiley   +1 more source