Results 91 to 100 of about 20,186 (218)
The Chemical Record, EarlyView.This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros +5 more
wiley +1 more source
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
The Chemical Record, EarlyView.Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source
Complex Chemistry of a Chiral Terpyridine Ligand Based on (1R)‐(+)‐Camphor
Zeitschrift für anorganische und allgemeine Chemie, EarlyView.From (1R)‐(+)‐camphor, a chiral terpyridine ligand is accessible in a few steps that coordinates to divalent metal ions of the first and second transition metal row. From structural characterization, the steric repulsion of the two equatorial methyl groups of the tetrahydromethanoquinoline units becomes evident, which causes cyclometalation of the ...
Julia Ehrhard +2 more
wiley +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca +4 more
wiley +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT This study characterized the long‐term pharmacokinetic profile of a 1% fipronil pour‐on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC–MS/MS.
Stefani Maria Ferreira +8 more
wiley +1 more source
Synthesis and Thermolysis of Ylidyl‐Substituted Stannylenes
Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 12, 3 August 2026.The synthesis of an amino(ylidyl)stannylene is reported. The title compound was characterized via X‐ray diffraction and features a Sn2C2 heterocycle. Thermal treatment of the stannylene leads to the elimination of the amine. The products of the thermolysis are discussed.
Pascal Weisenburger +3 more
wiley +1 more source
Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter +5 more
wiley +2 more sources
Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.An enantioselective Mannich reaction using barbituric acids as nucleophiles provides access to chiral heterocycles bearing quaternary stereocenters. The transformation is catalyzed by a bifunctional thiourea with high selectivity. An immobilized catalyst enables recycling and application under continuous‐flow conditions, offering an efficient and ...
Rodrigo Sánchez‐Molpeceres +4 more
wiley +1 more source