Results 91 to 100 of about 35,216 (249)

Grafting of multiwalled carbon nanotubes with pyrazole derivatives: characterization, antimicrobial activity and molecular docking study

International Journal of Nanomedicine, 2019
Nadia Hanafy Metwally,1 Gamal Riad Saad,1 Esraa Azmy Abd El-Wahab21Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt; 2Department of Engineering Mathematics and Physics, Faculty of Engineering Shoubra, Benha UniversityCorrespondence:
Metwally NH, Saad GR, Abd El-Wahab EA
doaj  

Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies

Future Journal of Pharmaceutical Sciences
Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer.
Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla   +3 more
doaj   +1 more source

Adsorption of Mn2+, Co2+, and Ni2+ in MOF-808 and pyrazole-modified MOF-808: Selectivity trends assessed with microcalorimetry and spectroscopic analysis

Chemical Engineering Journal Advances
Zirconium(IV)-based metal-organic framework (MOF) MOF-808 and pyrazole-functionalized MOF-808 were investigated for the selective adsorption of Mn2+, Co2+, and Ni2+, the key components of lithium-ion battery cathodes.
Boyoung Song, Nadine Kabengi, Jackson Geary, Dorina F. Sava Gallis, Kevin Leung, Anastasia G. Ilgen   +5 more
doaj   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, EarlyView.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile

Acta Crystallographica Section E, 2012
In the title pyrazole derivative, C19H15N3O, the central pyrazole ring makes dihedral angles of 42.71 (9) and 61.34 (9)°, respectively, with the phenyl and p-tolyl rings.
Hatem A. Abdel-Aziz, Hazem A. Ghabbour, Suchada Chantrapromma, Hoong-Kun Fun   +3 more
doaj   +1 more source

Anticancer effects of the Novel Pyrazolyl-Urea GeGe-3 [PDF]

In a screen of over 200 novel pyrazole compounds, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl)ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a potential anticancer compound.
Michael Ladomery, E. Cooper, Williams, Ashleigh, Greenhough, Alexander, Ladomery, Michael, Bethany Clark, Perry, Laura, Williams, Erika Iervasi, Ponassi, Marco, Iervasi, Erika, Emma Cooper, B. Clark, Chiara Brullo, E. Iervasi, Brullo, Chiara, Ashleigh Williams, Marco Ponassi, Alexander Greenhough, Laura Perry, Cooper, Emma, Clark, Bethany, L. Perry, M. Ladomery, A. Greenhough, M. Ponassi, C. Brullo   +26 more
core   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, EarlyView.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

tert-Butyl 4-{[5-(4-chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}piperazine-1-carboxylate

Acta Crystallographica Section E, 2010
In the title pyrazole derivative, C25H26ClFN4O3, both benzene rings are twisted out of the plane through the pyrazole ring, with dihedral angles of 67.62 (10) and 27.63 (10)° for the fluoro- and chloro-substituted rings ...
Seik Weng Ng, S. Sarveswari, V. Vijayakumar, R. Venkat Ragavan, Edward R. T. Tiekink   +4 more
doaj   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source