Results 41 to 50 of about 16,147 (226)

Isoxazole Nucleosides as Building Blocks for a Plausible Proto‐RNA [PDF]

, 2022
The question of how RNA, as the principal carrier of genetic information evolved is fundamentally important for our understanding of the origin of life.
Thea Schinkel, Rovo, Petra ; https://orcid.org/, Carell, Thomas, Florian Schelter, Sidney Becker, Sarah Hübner, Hübner, Sarah, Antony Crisp, Xu, Felix, Rovo, Petra, Felix Xu, Becker, Sidney, Crisp, Antony, Romeo C. A. Dubini, Schinkel, Thea, Thomas Carell, Schelter, Florian, Petra Rovó, Dubini, Romeo C. A.   +18 more
core   +1 more source

4-(4-Chlorophenyl)-5-phenylisoxazole

Acta Crystallographica Section E, 2009
The title compound, C15H10ClNO, is a functionalized isoxazole with a chlorophenyl and a phenyl substitutent. The mean plane of the isoxazole ring is inclined to those of the two benzene ring mean planes by 38.32 (16) and 43.91 (18 ...
M. Krishnaiah, R. Ravi Kumar, Thanzaw Oo, Pho Kaung   +3 more
doaj   +1 more source

Therapeutic Potential of Isoxazole-(Iso)oxazole Hybrids: Three Decades of Research. [PDF]

Int J Mol Sci
Heterocyclic compounds are a common subject in the field of medicinal chemistry due to their numerous pharmaceutical applications. Among these, nitrogen- and oxygen-containing five-membered heterocyclic rings, namely oxazole and isoxazole, are ...
Bąchor U, Mączyński M, Sochacka-Ćwikła A.   +2 more
europepmc   +2 more sources

A Synergistic Inhibitor Development Strategy Against Human UDP-Galactose-4-Epimerase. [PDF]

Angew Chem Int Ed Engl
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
Browne WM, Pettinger J, Weckwerth T, Purkiss A, Lok SH, Penicaut L, Ogrodowicz R, Prema R, Kunzelmann S, Roustan C, Bineva-Todd G, Pieters S, Zappacosta F, Doherty AE, Oram I, Soudy C, Quinlan R, Redmond J, Kjaer S, House D, Mouilleron S, Bush JT, Schumann B.   +22 more
europepmc   +2 more sources

Synthesis of Some Novel Heterocyclic and Schiff Base Derivatives as Antimicrobial Agents

Molecules, 2015
Treatment of 2,3-diaryloxirane-2,3-dicarbonitriles 1a–c with different nitrogen nucleophiles, e.g., hydrazine, methyl hydrazine, phenyl hydrazine, hydroxylamine, thiosemicarbazide, and/or 2-amino-5-phenyl-1,3,4-thiadiazole, afforded pyrazole, isoxazole ...
Mohamed E. Azab, Sameh A. Rizk, Abd El-Galil E. Amr   +2 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

A Facile Approach to Bis(isoxazoles), Promising Ligands of the AMPA Receptor

Molecules, 2021
A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated.
Dmitry A. Vasilenko, Kirill S. Sadovnikov, Kseniya N. Sedenkova, Dmitry S. Karlov, Eugene V. Radchenko, Yuri K. Grishin, Victor B. Rybakov, Tamara S. Kuznetsova, Vladimir L. Zamoyski, Vladimir V. Grigoriev, Vladimir A. Palyulin, Elena B. Averina   +11 more
doaj   +1 more source

Relapses, Comorbidities, and Predictors of Outcome in Anti‐GABAA Receptor Encephalitis

Annals of Neurology, EarlyView.
Objectives To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti‐γ‐aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utility of LIM‐domain‐only‐protein 5 (LMO5) antibodies as tumor markers.
Claudia Papi, Chiara Milano, Laura Marmolejo, Ana Beatriz Serafim, Esther Aguilar, Mar Guasp, Elianet Fonseca, Mateus Mistieri Simabukuro, Raffaele Iorio, Yuki Fukami, Maria Lucia Schmitz Ferreira Santos, Takashi Miwa, Takashi Araga, Yuto Uchida, Masanori Kurihara, Satoshi Okada, Luz Victoria Garcia, Kenichi Kaida, Natalia Spinola Costa da Cunha, Alberto Vogrig, Florian Lamblin, Juna M. de Vries, Livia Almeida Dutra, Romana Höftberger, Maarten J. Titulaer, Jesús Planagumà, Lidia Sabater, Eugenia Martinez‐Hernandez, Thais Armangué, Francesc Graus, Takahiro Iizuka, Josep Dalmau, Marianna Spatola, Anti‐GABAAR encephalitis study group   +33 more
wiley   +1 more source

Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents

Acta Pharmaceutica, 2014
A novel series of thiophenes having biologically active sulfonamide 2-11, 3-methylisoxazole 12, 4-methoxybenzo[d] thiazole 13, quinoline 14, 15, benzoylphenylamino 16, and anthracene-9,10-dione 17 moieties were prepared.
Ghorab Mostafa M., Bashandy Mahmoud S., Alsaid Mansour S.   +2 more
doaj   +1 more source

Synthesis, chemo-informatics, and anticancer evaluation of fluorophenyl-isoxazole derivatives

Open Chemistry, 2021
The current study aimed to design and synthesize a novel series of fluorophenyl-isoxazole-carboxamide derivatives and evaluate their antiproliferative activities.
Hawash Mohammed, Jaradat Nidal, Abualhasan Murad, Amer Johnny, Levent Serkan, Issa Shahd, Ibrahim Sameeha, Ayaseh Aseel, Shtayeh Tahrir, Mousa Ahmed   +9 more
doaj   +1 more source