Results 61 to 70 of about 16,147 (226)

Ring-Opening Fluorination of Isoxazoles

Organic Letters, 2022
A ring-opening fluorination of isoxazoles has been developed. Upon treatment of isoxazoles with an electrophilic fluorinating agent (Selectfluor), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds. This method features mild reaction conditions, good functional group tolerance, and a simple experimental procedure ...
Masaaki Komatsuda, Hugo Ohki, Hiroki Kondo Jr., Ayane Suto, Junichiro Yamaguchi   +4 more
openaire   +2 more sources

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

3,5-Bis(4-fluorophenyl)isoxazole

, 2012
In the crystal structure of the title compound, C15H9F2NO, the complete molecule is generated by a crystallographic twofold rotation axis and the O and N atoms of the central isoxazole ring are statistically disordered with equal site occupancies.
S. Samshuddin, B. Narayana, Hoong-Kun Fun, Suhana Arshad, B. K. Sarojini   +4 more
core   +1 more source

Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β‑Cells

, 2016
Novel strategies are needed to modulate β-cell differentiation and function as potential β-cell replacement or restorative therapies for diabetes. We previously demonstrated that small molecules based on the isoxazole scaffold drive neuroendocrine ...
Svetlana Earnest (1418557), Claudia Savoia (1418551), Jay W. Schneider (1418569), Zhimin Huang (147312), Chonlarat Wichaidit (1418560), Elhadji M. Dioum (1418566), Michele R. Hutchison (420537), Melanie H. Cobb (1418563), Michael A. Kalwat (1418572), Kathleen McGlynn (1418554)   +9 more
core   +2 more sources

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Machine learning‐driven advances in carbon‐based quantum dots: Opportunities accompanied by challenges

Responsive Materials, EarlyView.
Machine learning provides a unifying framework to connect structure, fluorescence properties, and applications of carbon‐based quantum dots. This review highlights how data‐driven strategies enable fluorescence regulation, reveal underlying mechanisms, and accelerate the rational design of functional carbon dots.
Liangfeng Chen, Siwei Yang, Xiangqian Cui, Ziheng Liu, Hang Wang, Yongqiang Li, Peng He, Miao Wang, Guqiao Ding   +8 more
wiley   +1 more source

Synthesis and Structure of Unsymmetrical Anthracenyl-Isoxazole Antitumor Agents Via the Diastereoselective Bromination of 3-(9′-Anthryl)-Isoxazole Esters

Crystals
In pursuit of unsymmetrical precursors for the novel series of anthracenyl-isoxazole amide (AIM) antitumor agents, a series of substituted anthracenes were subjected to bromination and re-aromatization in our study, during which we solved four single ...
Michael J. Campbell, Daniel A. Decato, Chun Li, Matthew J. Weaver, Nicholas R. Natale   +4 more
doaj   +1 more source

1-(3-p-Tolylisoxazol-5-yl)cyclohexanol

Acta Crystallographica Section E, 2009
The title compound, C16H19NO2, contains two molecules in the asymmetric unit. Each molecule is composed of three interconnected rings, two essentially planar rings, viz.
Lahcen El Ammari, Mohamed Soufiaoui, Rachid Benhida, Khalid Bougrin, Ouafaa Khalil   +4 more
doaj   +1 more source

Unusual backfolded binding poses of BAZ2A bromodomain binders

Acta Crystallographica Section D, EarlyView.
We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove, Giulia Cazzanelli, Vito Giuseppe D'Agostino, Pablo Andres Vargas Rosales, Amedeo Caflisch, Graziano Lolli   +5 more
wiley   +1 more source

Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry [PDF]

, 2011
The versatility of the isoxazole generating nitrile oxide–alkyne Huisgen cycloaddition for provision of chemically modified oligonucleotides has been extended; in a novel approach isoxazole conjugated oligodeoxyribonucleotides have been constructed by ...
Ni Cheallaigh, Aisling, Colin Freeman, Freeman, Colin, Heaney, Frances, Frances Heaney, Aisling Ni Cheallaigh   +5 more
core   +1 more source