Results 71 to 80 of about 17,124 (205)
Beiträge zur Kenntniss der Isoxazole
, 1899 BEITRÄGE ZUR KENNTNISS DER ISOXAZOLE Beiträge zur Kenntniss der Isoxazole ([1]) Binding ( - ) Title page ([1]) Dedication ([3]) Einleitung. ([5]) Experimenteller Teil (19) A.
Zöpfchen, Hermann
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Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo +8 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 29, 7 August 2026.A Pd/Cu cooperative catalytic system enables the direct C–H functionalization of a diverse range of five‐membered and benzo‐fused heterocycles with iodinated hexaarylborazines, providing efficient access to previously inaccessible heterocycle‐functionalized borazines.
Fan Huang +5 more
wiley +1 more source
, 2016 Novel strategies are needed to modulate β-cell differentiation and function as potential β-cell replacement or restorative therapies for diabetes. We previously demonstrated that small molecules based on the isoxazole scaffold drive neuroendocrine ...
Svetlana Earnest (1418557) +9 more
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Crystal structure of (5-chloro-2-hydroxyphenyl)(3-methylisoxazolo[5,4-b]pyridin-5-yl)methanone
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C14H9ClN2O3, the fused pyridine and isoxazole rings are approximately planar, making a dihedral angle of 1.14 (16)°. The molecule is twisted with the benzene ring and the mean plane through the fused pyridine-isoxazole ring system ...
Rajamani Raja +3 more
doaj +1 more source
A concise synthesis of isoxazole-based side chain of Micafungin
, 2019 A concise synthesis of key isoxazole-based side chain of Micafungin, an USFDA approved anti-fungal agent, has been delineated. The route design notably involves a one pot regioselective isoxazole construction from the corresponding aryl aldehyde and ...
Ismail Hussain (6840758) +4 more
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Synthesis of some n-substituted hydrazidescontaining isoxazole heterocycle
, 2019 Ethyl 4-(4-nitrophenyl)-2,4-dioxobutanoate (1), ethyl 5-(4-nitrophenyl)isoxazole-3-carboxylate (2), 5-(4-nitrophenyl)isoxazole-3-carbohydrazide (3) and eight new N-substituted hydrazides (4a-h) containing isoxazole heterocycle were synthesized.
Nguyen Dang Dat +2 more
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Therapeutic Potential of Isoxazole-(Iso)oxazole Hybrids: Three Decades of Research. [PDF]
Int J Mol SciHeterocyclic compounds are a common subject in the field of medicinal chemistry due to their numerous pharmaceutical applications. Among these, nitrogen- and oxygen-containing five-membered heterocyclic rings, namely oxazole and isoxazole, are ...
Bąchor U +2 more
europepmc +2 more sources
1,3′-Dimethyl-2-oxo-6′-phenyl-7′H-spiro[indoline-3,4′-isoxazolo[5,4-b]pyridine]-5′-carbonitrile
IUCrDataThe title compound, C22H16N4O2, crystallizes in the monoclinic space group P21/c with two independent molecules, A and B, in the asymmetric unit. The isoxazole ring is inclined to the pyridine ring system, the indoline ring, and the phenyl ring by 8.00 ...
S. Logalakshmi +4 more
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Synthesis of Carbohydrate-Isoxazole Conjugates
Herein we report the synthesis of galactose and gulose derivatives that contain isoxazole moiety at C(3 ...
Lugiņina, Jevgeņija +3 more
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