Results 71 to 80 of about 16,147 (226)

3-Benzyl-5-methyl-1,2-benzoxazole 2-oxide

Acta Crystallographica Section E, 2012
In the title compound, C15H13NO2, the isoxazole unit and the attached benzene ring are almost coplanar, making a dihedral angle of 1.42 (8)°.
G. Anuradha, Vasuki Gopalsamy, A. Veera Reddy, G. Laxminarasimhulu   +3 more
doaj   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Theoretical Study of Thermal Decomposition Mechanisms of Isoxazole

, 1997
Density functional theory and ab initio calculations were carried out to investigate two probable unimolecular decomposition channels of isoxazole. The calculated structural parameters, dipole moment, and vibrational frequencies of isoxazole are in good ...
Zhou, Xuefeng, Liu, Ruifeng, Higgins, James   +2 more
core   +1 more source

Methyl 3-(4-isopropylphenyl)-1-phenyl-3,3a,4,9b-tetrahydro-1H-chromeno[4,3-c]isoxazole-3a-carboxylate

Acta Crystallographica Section E, 2011
In the title compound, C27H27NO4, the five-membered isoxazole ring adopts an envelope conformation and the six-membered pyran ring adopts a half-chair conformation.
J. Kanchanadevi, G. Anbalagan, J. Srinivasan, M. Bakthadoss, V. Manivannan   +4 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Methyl 3-phenylisoxazole-5-carboxylate

Acta Crystallographica Section E, 2014
In the title compound, C11H9NO3, the dihedral angle between the isoxazole and phenyl rings is 19.79 (12), while the ester group is inclined to the isoxazole group by 12.14 (6)°.
Li Wang, Ya-jun Li, Yao-dong Li, Wei Zhang, Rui Xu   +4 more
doaj   +1 more source

Synthesis and biological evaluation of (3-arylisoxazol-5-yl) methyl 6-fluoro-4-oxo-4H-chromene-2-carboxylates as antioxidant and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2017
A series of novel (3-aryl-1,2-oxazol-5-yl) methyl 6-fluoro-4-oxo-4H- -chromene-2-carboxylate derivatives (C1-C12) were synthesized by Cu (I) catalyzed reaction of in situ generated nitrile oxides with prop-2-yn-1-yl 6-fluoro-4-oxo-4H-chromene-2 ...
Battula Kumaraswamy, Narsimha Sirassu, Nagavelli Vasudeva Reddy, Srinivasa Rao Mutheneni   +3 more
doaj   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Solvent‐Induced Covalent Bond Softening Boosts Battery Voltage

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
The strong attractive interaction between the nucleophilic center of the solvent and the electrophilic region of the covalently bonded cathode fragment triggers charge transfer. This results in the electron population in the antibonding orbital of the covalent bond, leading to bond weakening and elongation, and consequently increasing the cathode ...
Yanyan Wang, Zhijie Wang, Mengzi Geng, Chunzhen Yang, Guangchao Li, Jean‐Marie Tarascon, Biao Zhang   +6 more
wiley   +2 more sources

Development of a Brain‐Penetrant Nurr1 Agonist Tool

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Nuclear receptor‐related 1 (Nurr1) is a ligand‐activated transcription factor with neuroprotective properties, thought to hold therapeutic potential in neurodegeneration. Here, we developed a potent, brain‐penetrant Nurr1 agonist to study the effects of pharmacological Nurr1 activation in the CNS in vivo. The ligand‐sensing transcription factor nuclear
Jan Vietor, Tanja Stiller, Christian Gege, Wael Saeb, Úrsula López‐García, Hella Kohlhof, Daniel Vitt, Daniel Merk   +7 more
wiley   +1 more source