Results 81 to 90 of about 24,259 (231)

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, EarlyView.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]

, 2012
In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F, Burley, Glenn A, Ravoo, Bart Jan, Rinnen, Stefan, Schulz, Christian, Singh, Ishwar, Wendeln, Christian   +6 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Stereoselective synthesis of α-amino-C-phosphinic acids and derivatives [PDF]

, 2016
α-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have
Cativiela, Carlos, Ordóñez, Mario, Sayago, Francisco J., Viveros-Ceballos, José Luis   +3 more
core   +3 more sources

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Machine learning‐driven advances in carbon‐based quantum dots: Opportunities accompanied by challenges

Responsive Materials, EarlyView.
Machine learning provides a unifying framework to connect structure, fluorescence properties, and applications of carbon‐based quantum dots. This review highlights how data‐driven strategies enable fluorescence regulation, reveal underlying mechanisms, and accelerate the rational design of functional carbon dots.
Liangfeng Chen, Siwei Yang, Xiangqian Cui, Ziheng Liu, Hang Wang, Yongqiang Li, Peng He, Miao Wang, Guqiao Ding   +8 more
wiley   +1 more source

Crystal structure of (5-chloro-2-hydroxyphenyl)(3-methylisoxazolo[5,4-b]pyridin-5-yl)methanone

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C14H9ClN2O3, the fused pyridine and isoxazole rings are approximately planar, making a dihedral angle of 1.14 (16)°. The molecule is twisted with the benzene ring and the mean plane through the fused pyridine-isoxazole ring system ...
Rajamani Raja, Nataraj Poomathi, Paramasivam T. Perumal, A. SubbiahPandi   +3 more
doaj   +1 more source

Metal‐Free Electrophilic Borylative Cyclizations of Alkynes

The Chemical Record, EarlyView.
Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil, Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +3 more
wiley   +1 more source

1,3′-Dimethyl-2-oxo-6′-phenyl-7′H-spiro[indoline-3,4′-isoxazolo[5,4-b]pyridine]-5′-carbonitrile

IUCrData
The title compound, C22H16N4O2, crystallizes in the monoclinic space group P21/c with two independent molecules, A and B, in the asymmetric unit. The isoxazole ring is inclined to the pyridine ring system, the indoline ring, and the phenyl ring by 8.00 ...
S. Logalakshmi, Panneerselvam Yuvaraj, Dhruba Jyoti Boruah, R. Raja, G. Puthilibai   +4 more
doaj   +1 more source

Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay [PDF]

, 2013
Many microbial pathogens rely on a type II fatty acid synthesis (FASII) pathway that is distinct from the type I pathway found in humans. Enoyl-acyl carrier protein reductase (ENR) is an essential FASII pathway enzyme and the target of a number of ...
Afanador, G.A., Anderson, J.W., Cheng, G., Fidock, D.A., Fishwick, C.W., Fomovska, A., Freire, E., Freundlich, J.S., Jacobus, D.P., Kozikowski, A.P., McLeod, R., McPhillie, M., Muench, S.P., Prigge, S.T., Rice, D.W., Schoen, A., Shieh, H-M., Stec, J., Zhou, Y.   +18 more
core   +1 more source