Results 81 to 90 of about 17,124 (205)

An Easy Entry to Sugar Isoxazole Derivatives Via Michael Addition/1,3-Dipolar Cycloaddition Reactions

We report a novel approach for isoxazole- or/and thioether-linked glycoconjugates whic are based on sequential Michael addition - 1,3-dipolar ...
Lugiņina, Jevgeņija, Beļakovs, Sergejs, Turks, Māris, Rjabovs, Vitālijs   +3 more
core  

4-[4-(4-Fluorophenyl)-1,2-oxazol-5-yl]pyridine

IUCrData
The title compound, C14H9FN2O, crystallizes in the monoclinic space group P21/c. The dihedral angles between the central isoxazole ring and the 4-fluorophenyl and pyridine rings are 37.51 (10) and 12.11 (15)°, respectively.
Pierre Koch, Dieter Schollmeyer
doaj   +1 more source

Targeting hematological malignancies with isoxazole derivatives [PDF]

Compounds with a heterocyclic isoxazole ring are well known for their diverse biologic activities encompassing antimicrobial, antipsychotic, immunosuppressive, antidiabetic and anticancer effects.
Majirská, M, Diniz, C, Vojtek, M, Pilátová, MB, Kudlicková, Z   +4 more
core   +1 more source

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

Beilstein Journal of Organic Chemistry, 2016
Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov, Marsel Z. Shafikov, Nikolai A. Beliaev, Natalia N. Volkova, Tetyana V. Beryozkina, Wim Dehaen, Zhijin Fan, Viktoria V. Grishko, Gert Lubec, Pavel A. Slepukhin, Vasiliy A. Bakulev   +10 more
doaj   +1 more source

Collision Induced Dissociation of Deprotonated Isoxazole and 3‑Methyl Isoxazole via Direct Chemical Dynamics Simulations

Isoxazoles are an important class of organic compounds widely employed in synthesis and drug design. Fragmentation chemistry of the parent isoxazole molecule and its substituents has been the subject of several experimental and theoretical investigations.
Manikandan Paranjothy (2018071), Himani Priya (14831456)   +1 more
core   +1 more source

Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors

, 2016
The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an amino-isoxazole fragment and known BET inhibitors, a structure-based drug design effort lead to a novel isoxazole azepine ...
Brian K. Albrecht (1417963), Shivangi Joshi (1398922), Florence Poy (240698), Jean-Christophe Harmange (1398934), Yves Leblanc (1398952), Christopher G. Nasveschuk (334912), Rishi G. Vaswani (1398928), Nandana Bangalore Srinivasamurthy (1912945), Eneida Pardo (1398916), James E. Audia (1398949), Sreegouri Yellapantula (1912942), Victor S. Gehling (1398931), Alexandre Côté (1398955), Barbara M. Bryant (1912939), Swarnakumari Birudukota (1912951), Louise Bergeron (1417939), Steve Bellon (1398937), Robert J. Sims (1417966), Michael C. Hewitt (1912948), Hariharan Jayaram (1417942), Jennifer A. Mertz (1417945), Ravichandran Sankaranarayanan (1912954), Peter Sandy (235034), Alexander M. Taylor (1398943)   +23 more
core   +1 more source

Use of isoxazole derivatives as cyclooxygenase inhibitors

, 2010
isoxazole derivatives development as cyclooxygenase ...
TACCONELLI S, VITALE, PAOLA, DI NUNNO L, STUPPIA L., PATRIGNANI P, SCILIMATI, Antonio, PORRECA E   +6 more
core  

Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Molecules
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Altynay Zh. Shaibek, Manshuk S. Nurmaganbetova, Aigerym R. Zhasymbekova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Irina A. Kolesnik, Evgenij A. Dikusar, Tatiana I. Terpinskaya, Vladimir A. Kulchitsky, Vladimir I. Potkin, Alexander L. Pushkarchuk, Dmitry A. Lyakhov, Dominik L. Michels   +14 more
doaj   +1 more source

New Quinazolin-4(3H)-One Derivatives Incorporating Isoxazole Moiety as Antioxidant Agents: Synthesis, Structural Characterization, and Theoretical DFT Mechanistic Study

Pharmaceuticals
Background: This research centers on the development and spectroscopic characterization of new quinazolin-4(3H)-one-isoxazole derivatives (5a–e). The aim was to investigate the regioselectivity of the 1,3-dipolar cycloaddition involving arylnitriloxides ...
Yassine Rhazi, Riham Sghyar, Noemi Deak, Bouchra Es-Sounni, Bouchra Rossafi, Albert Soran, Mustapha Laghmari, Azize Arzine, Asmae Nakkabi, Khalil Hammani, Samir Chtita, Mohammed M. Alanazi, Gabriela Nemes, Mohamed El. Yazidi   +13 more
doaj   +1 more source

tert-Butyl [(4-fluoro-3-isopropoxyisoxazol-5-yl)methyl](phenylsulfonyl)carbamate

IUCrData
The title compound, C18H23FN2O6S, a new derivative of a fluoroisoxazole containing sulfonamide functionality has been structurally characterized. The C—S—N—Cipr and C—S—N—Ccarb (ipr = 3-isopropoxyisoxazole, carb = carbamate) torsion angles are 111.1 (3)°
Mohd Abdul Fatah Abdul Manan, David B. Cordes   +1 more
doaj   +1 more source