Results 81 to 90 of about 16,147 (226)
Photocatalytic Vanadium‐Mediated Amination of Benzene With Hydroxylamine
Chemistry – A European Journal, Volume 32, Issue 22, 9 June 2026.Photochemical activation of N‐phenylphenothiazine (PPT) enables a selective direct benzene amination with hydroxylamine in the presence of various vanadium catalysts under mild reaction conditions. Spectroscopic and kinetic analyses identify a key vanadium(IV)‐hydroxylamine intermediate, elucidate the crucial roles of the acidic medium, the ...
Dana Králová +6 more
wiley +1 more source
Bayesian Optimization of Solvent‐Free Thermal Amidation via Reactive Extrusion
Chemistry – A European Journal, Volume 32, Issue 22, 9 June 2026.Thermal amidation between a carboxylic acid and an amine was successfully conducted in an extruder in the absence of solvent, coupling agent, or catalyst, relying on an adapted Bayesian Optimization protocol. Active pharmaceutical ingredient moclobemide was synthesized on a larger scale, achieving excellent yield and low Process Mass Intensity (PMI ...
Matthieu Lavayssiere +2 more
wiley +1 more source
A concise synthesis of isoxazole-based side chain of Micafungin
, 2019 A concise synthesis of key isoxazole-based side chain of Micafungin, an USFDA approved anti-fungal agent, has been delineated. The route design notably involves a one pot regioselective isoxazole construction from the corresponding aryl aldehyde and ...
Ismail Hussain (6840758) +4 more
core +1 more source
Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II
European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley +1 more source
Crystal structure of (5-chloro-2-hydroxyphenyl)(3-methylisoxazolo[5,4-b]pyridin-5-yl)methanone
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C14H9ClN2O3, the fused pyridine and isoxazole rings are approximately planar, making a dihedral angle of 1.14 (16)°. The molecule is twisted with the benzene ring and the mean plane through the fused pyridine-isoxazole ring system ...
Rajamani Raja +3 more
doaj +1 more source
Dual‐Site Catalysis in Electrocatalytic C–N Coupling: Challenges and Design Principles
ChemElectroChem, Volume 13, Issue 11, 3 June 2026.This review examines dual‐site catalysis in electrocatalytic C─N coupling through four recurring challenges: energetic barriers, kinetic mismatch, selectivity loss, and systemic constraints. It highlights how rationally designed dual‐site catalysts cooperatively lower reaction barriers, synchronize intermediate generation, suppress competing pathways ...
Tao You +3 more
wiley +1 more source
ChemistryEurope, Volume 4, Issue 6, June 2026.Polycyclic intermediates enable stereocontrolled synthesis of densely functionalized cis‐1,3‐diamine and amino alcohol carbocycles and heterocycles via structural‐to‐functional complexity transformations from low‐complexity starting material. Cis‐1,3‐functionalized carbocycles and saturated heterocycles are ubiquitous motifs in natural products ...
Jiayi Zhu +2 more
wiley +1 more source
Beiträge zur Kenntnis der Isoxazole
, 1902 BEITRÄGE ZUR KENNTNIS DER ISOXAZOLE Beiträge zur Kenntnis der Isoxazole ([1]) Binding ( - ) Title page ([1]) Dedication ([3]) Section ([5]) Einleitung. ([6]) Experimenteller Teil.
Mumm, Otto
core
Targeting hematological malignancies with isoxazole derivatives [PDF]
Compounds with a heterocyclic isoxazole ring are well known for their diverse biologic activities encompassing antimicrobial, antipsychotic, immunosuppressive, antidiabetic and anticancer effects.
Majirská, M +4 more
core +1 more source
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, Volume 3, Issue 2, Page 237-251, June 2026.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source