Results 91 to 100 of about 16,147 (226)
An isoxazole approach to the coleophomones [PDF]
, 2007 Coleophomones, metabolites reported first in a Japanese patent in 1998 and then by Merck in 2000 from a Coleophoma fungus, have antifungal and antibacterial properties and inhibit bacterial cell-wall transglycosylase and human heart chymase. Their unique
Wing Hoi (Angella) Yuen (7166246) +1 more
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Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors
, 2016 The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an amino-isoxazole fragment and known BET inhibitors, a structure-based drug design effort lead to a novel isoxazole azepine ...
Brian K. Albrecht (1417963) +23 more
core +1 more source
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner +6 more
wiley +1 more source
Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne +22 more
wiley +1 more source
Beiträge zur Kenntnis der Isoxazole
, 1900 BEITRÄGE ZUR KENNTNIS DER ISOXAZOLE Beiträge zur Kenntnis der Isoxazole ([1]) Binding ( - ) Title page ([1]) Dedication ([3]) Section ([5]) Einleitung. ([7]) Experimenteller Teil. (18) I.
Thomaschewski, Paul
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Beiträge zur Kenntniss der Isoxazole
, 1899 BEITRÄGE ZUR KENNTNISS DER ISOXAZOLE Beiträge zur Kenntniss der Isoxazole ([1]) Binding ( - ) Title page ([1]) Dedication ([3]) Einleitung. ([5]) Experimenteller Teil (19) A.
Zöpfchen, Hermann
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1,3′-Dimethyl-2-oxo-6′-phenyl-7′H-spiro[indoline-3,4′-isoxazolo[5,4-b]pyridine]-5′-carbonitrile
IUCrDataThe title compound, C22H16N4O2, crystallizes in the monoclinic space group P21/c with two independent molecules, A and B, in the asymmetric unit. The isoxazole ring is inclined to the pyridine ring system, the indoline ring, and the phenyl ring by 8.00 ...
S. Logalakshmi +4 more
doaj +1 more source
Synthetic isoxazole as antiplatelet agent
Platelets, 2013 Abstract Nine synthetic isoxazoles were evaluated as antiplatelet agents and studied the possible mechanism of more active compound. The initial screening was evaluating all compounds against platelet aggregation assays. The most active compound was isoxazole 8 showing an inhibition of platelet aggregation around 70%. In subsequent experiments, ADP and
Gutierrez, Margarita +4 more
openaire +4 more sources
Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application
European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C16H17ClN2O3, two molecules, A and B, with different conformations, comprise the asymmetric unit. In molecule A, the C=O group of the ester points away from the benzene ring [C—C—C=O = −170.8 (3)°], whereas in molecule B, it points
Ilya Efimov +2 more
doaj +1 more source