Results 111 to 120 of about 16,147 (226)

Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives

, 2019
Background Isoxazole is an important pharmacophore in medicinal chemistry with a wide range of pharmacological activities. The present study deals with the synthesis and evaluation of antinociceptive potential of nine novel 3-substituted-isoxazole-4 ...
Hajira Bibi, Muzaffar Abbas, Humaira Nadeem, Muazzam Arif   +3 more
core   +1 more source

Isoxazole Derivatives as Regulators of Immune Functions

, 2018
In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds.
Marcin Mączyński, Michał Zimecki, Urszula Bąchor   +2 more
core   +1 more source

5-Amino-3-(4-pyridyl)isoxazole

, 2008
In the title compound, C8H7N3O, there are two independent molecules in the asymmetric unit, in which the angles between the pyridine ring and the isoxazole ring are 35.8 (6) and 10.6 (2)°.
Jian-Cheng Deng, Zheng Yao
core   +1 more source

Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

Molecules
Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely
Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Altynay Zh. Shaibek, Manshuk S. Nurmaganbetova, Aigerym R. Zhasymbekova, Oralgazy A. Nurkenov, Ekaterina A. Akishina, Irina A. Kolesnik, Evgenij A. Dikusar, Tatiana I. Terpinskaya, Vladimir A. Kulchitsky, Vladimir I. Potkin, Alexander L. Pushkarchuk, Dmitry A. Lyakhov, Dominik L. Michels   +14 more
doaj   +1 more source

Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents

, 2002
The 3-substituted phenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation.
Bhaduri, A. P., Kundu, B., Patra, A., Srinivasan, T., Dixit, M., Rastogi, S. K., Batra, S.   +6 more
core   +1 more source

New Quinazolin-4(3H)-One Derivatives Incorporating Isoxazole Moiety as Antioxidant Agents: Synthesis, Structural Characterization, and Theoretical DFT Mechanistic Study

Pharmaceuticals
Background: This research centers on the development and spectroscopic characterization of new quinazolin-4(3H)-one-isoxazole derivatives (5a–e). The aim was to investigate the regioselectivity of the 1,3-dipolar cycloaddition involving arylnitriloxides ...
Yassine Rhazi, Riham Sghyar, Noemi Deak, Bouchra Es-Sounni, Bouchra Rossafi, Albert Soran, Mustapha Laghmari, Azize Arzine, Asmae Nakkabi, Khalil Hammani, Samir Chtita, Mohammed M. Alanazi, Gabriela Nemes, Mohamed El. Yazidi   +13 more
doaj   +1 more source

Synthesis of Isoxazole Glycohybrids

We report a novel approach to isoxazole- or/and thioether-amine-linked ...
Lugiņina, Jevgeņija, Turks, Māris, Rjabovs, Vitālijs   +2 more
core  

tert-Butyl [(4-fluoro-3-isopropoxyisoxazol-5-yl)methyl](phenylsulfonyl)carbamate

IUCrData
The title compound, C18H23FN2O6S, a new derivative of a fluoroisoxazole containing sulfonamide functionality has been structurally characterized. The C—S—N—Cipr and C—S—N—Ccarb (ipr = 3-isopropoxyisoxazole, carb = carbamate) torsion angles are 111.1 (3)°
Mohd Abdul Fatah Abdul Manan, David B. Cordes   +1 more
doaj   +1 more source

Synthesis of some New Pyrazole and Isoxazole Derivatives of Sulphonamides

, 1995
School of Studies in Chemistry, Jiwaji University, Gwalior-474 011 Manu.1cript recei1•ed 9 March 1992. received 23 May 1994, accepted 15 June 1994 Synthesis of some New Pyrazole and Isoxazole Derivatives of ...
D. D. AGARWAL, M. DAMODHARAN, RAJEEV JAIN   +2 more
core   +1 more source

The preparation of an isoxazole derivative of 4-hydroxycoumarin

, 1998
A method for preparation of an isoxazole derivative of 4-hydroxycoumarin, 3-phenyl-5-(4-hydroxy-3-coumarinyl)-isoxazole has been described. The reaction sequence includes addition of bromine to 3-cinnamoyl-4-hydroxycoumarin, and the subsequent treatment ...
Krstic, L, Sukdolak, S, Stefanović, Milutin, Solujic, S, Sladić, Dušan   +4 more
core