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Isoxazole anthelmintics

Journal of Medicinal Chemistry, 1977
A series of 3-halo-5-phenyl- and 3-phenyl-5-haloisoxazoles has demonstrated anthelmintic activity at doses ranging from 16 to 500 mg/kg orally against the rat roundworm, Nippostrongylus braziliensis. In the 5-phenyl series a halogen at the 3 position of the isoxazole ring was required for activity.
J B, Carr, H G, Durham, D K, Hass
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Isoxazole Hydrate

Canadian Journal of Chemistry, 1974
X-Ray, n.m.r., and dielectric studies show that the hydrate of isoxazole is a typical type II clathrate hydrate in structure, in reorientation rates of host and guest molecules, and in composition.
Gough, S.R.   +3 more
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The isoxazole alkaloids

2001
Publisher Summary Natural products based on the isoxazole (1,2-oxazole) skeleton constitute a small, heterogeneous group of natural products encompassing at present more than 90 structures. This group has not traditionally been classified as a special alkaloid group and has never been reviewed as a group previously.
L, Rahbaek, C, Christophersen
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Isoxazoles with antipicornavirus activity

Journal of Medicinal Chemistry, 1985
The synthesis and evaluation of a series of 3,5-disubstituted isoxazoles as antipicornavirus agents have led to the discovery of several compounds effective in vitro against rhinovirus type 2 and poliovirus type 2. Compound 32 was found more effective than 4',6-dichloroflavan against both viruses and was evaluated orally in mice infected ...
G D, Diana   +5 more
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