Results 51 to 60 of about 12,790 (182)

3-Benzyl-5-methyl-1,2-benzoxazole 2-oxide

Acta Crystallographica Section E, 2012
In the title compound, C15H13NO2, the isoxazole unit and the attached benzene ring are almost coplanar, making a dihedral angle of 1.42 (8)°.
G. Anuradha, Vasuki Gopalsamy, A. Veera Reddy, G. Laxminarasimhulu   +3 more
doaj   +1 more source

Methyl 3-(4-isopropylphenyl)-1-phenyl-3,3a,4,9b-tetrahydro-1H-chromeno[4,3-c]isoxazole-3a-carboxylate

Acta Crystallographica Section E, 2011
In the title compound, C27H27NO4, the five-membered isoxazole ring adopts an envelope conformation and the six-membered pyran ring adopts a half-chair conformation.
J. Kanchanadevi, G. Anbalagan, J. Srinivasan, M. Bakthadoss, V. Manivannan   +4 more
doaj   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain‐Containing Proteins

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley   +1 more source

Methyl 3-phenylisoxazole-5-carboxylate

Acta Crystallographica Section E, 2014
In the title compound, C11H9NO3, the dihedral angle between the isoxazole and phenyl rings is 19.79 (12), while the ester group is inclined to the isoxazole group by 12.14 (6)°.
Li Wang, Ya-jun Li, Yao-dong Li, Wei Zhang, Rui Xu   +4 more
doaj   +1 more source

Synthesis and biological evaluation of (3-arylisoxazol-5-yl) methyl 6-fluoro-4-oxo-4H-chromene-2-carboxylates as antioxidant and antimicrobial agents [PDF]

Journal of the Serbian Chemical Society, 2017
A series of novel (3-aryl-1,2-oxazol-5-yl) methyl 6-fluoro-4-oxo-4H- -chromene-2-carboxylate derivatives (C1-C12) were synthesized by Cu (I) catalyzed reaction of in situ generated nitrile oxides with prop-2-yn-1-yl 6-fluoro-4-oxo-4H-chromene-2 ...
Battula Kumaraswamy, Narsimha Sirassu, Nagavelli Vasudeva Reddy, Srinivasa Rao Mutheneni   +3 more
doaj   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Relapses, Comorbidities, and Predictors of Outcome in Anti‐GABAA Receptor Encephalitis

Annals of Neurology, Volume 100, Issue 1, Page 139-150, July 2026.
Objectives To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti‐γ‐aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utility of LIM‐domain‐only‐protein 5 (LMO5) antibodies as tumor markers.
Claudia Papi, Chiara Milano, Laura Marmolejo, Ana Beatriz Serafim, Esther Aguilar, Mar Guasp, Elianet Fonseca, Mateus Mistieri Simabukuro, Raffaele Iorio, Yuki Fukami, Maria Lucia Schmitz Ferreira Santos, Takashi Miwa, Takashi Araga, Yuto Uchida, Masanori Kurihara, Satoshi Okada, Luz Victoria Garcia, Kenichi Kaida, Natalia Spinola Costa da Cunha, Alberto Vogrig, Florian Lamblin, Juna M. de Vries, Livia Almeida Dutra, Romana Höftberger, Maarten J. Titulaer, Jesús Planagumà, Lidia Sabater, Eugenia Martinez‐Hernandez, Thais Armangué, Francesc Graus, Takahiro Iizuka, Josep Dalmau, Marianna Spatola, Anti‐GABAAR encephalitis study group   +33 more
wiley   +1 more source

Clinical validation of a patient‐friendly saliva microsampling approach to monitor perampanel levels in people with epilepsy

Epilepsia, Volume 67, Issue 7, Page e102-e108, July 2026.
Abstract Perampanel (PER) is a third‐generation antiseizure medication (ASM) with a well‐established concentration–effect relationship. Saliva represents a non‐invasive alternative to plasma for therapeutic drug monitoring (TDM) of PER, as it reflects the free plasma fraction.
Valentina Franco, Francesca Dattrino, Michela Palmisani, Federica Tacchella, Elena Tartara, Valentina De Giorgis, Carlo Alberto Quaranta, Ludovica Pasca, Paola Rota, Emilio Russo, Andrea Romigi, Cecilie Johannessen Landmark, Guido Fedele, Cristina Tassorelli, Pierluigi Nicotera   +14 more
wiley   +1 more source

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source