Results 41 to 50 of about 8,235 (246)

Effects of RDL GABA Receptor Point Mutants on Susceptibility to Meta-Diamide and Isoxazoline Insecticides in Drosophila melanogaster. [PDF]

Insects
Simple Summary Insects have special receptors called RDL that regulate the effects of a neurotransmitter GABA in their nervous system. Interestingly, these receptors are also the main targets of many insecticides used to control pests.
Zhou T, Wu W, Ma S, Chen J, Huang J, Qiao X.   +5 more
europepmc   +2 more sources

Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity

Molecules, 2022
The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance.
K. Sedenkova, K. S. Andriasov, Marina G. Eremenko, Y. Grishin, V. Alferova, A. Baranova, N. Zefirov, O. Zefirova, V. Zarubaev, Y. Gracheva, E. Milaeva, E. Averina   +11 more
semanticscholar   +1 more source

Metal Chelates Based on Isoxazoline[60]fullerenes

, 2016
Fullerene C60 reacts with a variety of nitrile oxides, providing access to an array of fullerene-fused heterocycles bearing covalently linked chelate moieties.
Timothy M. Swager (1308438), Armando Ramírez-Monroy (2202334)   +1 more
core   +4 more sources

Synthesis, biological evaluation, molecular docking and in silico ADMET screening studies of novel isoxazoline derivatives from acridone

Arabian Journal of Chemistry, 2021
A series of new acridone derivatives from isoxazoline (2a-l) were synthesized via 1,3-dipolar cycloaddition reaction between a variety of aryl nitrile oxides and N-allyl acridones using simple and efficient methods.
Mohammed Aarjane, S. Slassi, A. Ghaleb, B. Tazi, A. Amine   +4 more
semanticscholar   +1 more source

Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase

Molecules, 2023
Isoxazoline is a nitrogen- and oxygen-containing five-membered heterocyclic scaffold with diverse biological profiles such as antimicrobial, fungicidal, anticancer, antiviral, analgesic and anti-inflammatory activity.
Daniele Sadutto, Paolo Guglielmi, Simone Carradori, Daniela Secci, Roberto Cirilli   +4 more
doaj   +1 more source

The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions: A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives

The Scientific World Journal, 2012
Isoxazoline γ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to the N-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO4.
Misal Giuseppe Memeo, Mariella Mella, Paolo Quadrelli   +2 more
doaj   +1 more source

Design and Synthesis of the First Spiro Bis(isoxazoline) Derivatives as Asymmetric Ligands

, 2016
A chiral bis(isoxazoline) ligand (SPRIX) containing a rigid spiro skeleton was designed and synthesized via a double intramolecular nitrile oxide cycloaddition.
Hiroaki Sasai (1764031), Midori A. Arai (1647700), Takayoshi Arai (1507834)   +2 more
core   +3 more sources

Navigating Nitration Chemistry: A Practical Guide to Reagents, Mechanisms, and Selectivity

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
This review highlights key contributions of modern nitration chemistry, emphasizing sustainable mechanistic platforms and comparing the performance of both organic and inorganic reagents across aromatic, ipso‐, olefin, alkyne, and heteroatom nitration. It provides the community with a clearer, unified perspective on current advances and facilitates the
Harry Lecomte, Anthony J. Fernandes, Dmitry Katayev   +2 more
wiley   +2 more sources

Biological, toxicological and molecular docking evaluations of isoxazoline-thiazolidine-2,4-dione analogues as new class of anti-hyperglycemic agents

Journal of Biomolecular Structure and Dynamics, 2021
In this work, three isoxazoline-thiazolidine-2,4-dione derivatives were synthesized and characterized by FT-IR, 1H-NMR, 13C-NMR and ESI-MS spectrometry. All compounds have been investigated for their α-amylase and α-glucosidase inhibitory activities.
S. Fettach, Fatima Zahra Thari, Zakaria Hafidi, K. Karrouchi, Kaoutar Bouathmany, Y. Cherrah, M. El achouri, L. Benbacer, M. El Mzibri, H. Sefrioui, K. Bougrin, M. E. Faouzi   +11 more
semanticscholar   +1 more source

The Isoxazoline Route to α-Methylen Lactones. [PDF]

Tetrahedron Letters, 1983
A new route to α-methylene lactones, important structural subunits of many natural products, has been developed using the nitrile oxide derived from 2-nitroethanol.
Alan P, Kozikowski, Arun K, Ghosh
openaire   +2 more sources