Results 61 to 70 of about 8,235 (246)

Synthesis and Characterization of Some Amides Containing Isoxazoline Ring

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
This work involves synthesis of amides containing isoxazoline unit starting with chalcone; 4-[3-(3‾-nitrophenyl)-2-propene- 1-one]-aniline[I]. 4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen ...
Kh. F. Ali, Dh. F Hussein, J. H. Tomma
doaj  

Fecal elimination of fluralaner in different carnivore species after oral administration

Frontiers in Veterinary Science
Fluralaner is a recent external parasiticide, first of a new class of drugs (isoxazoline parasiticides). It is widely used in companion animals both for its wide spectrum (fleas, ticks and other mites) but also for its ease of use (oral tablets given ...
Philippe Jacques Berny, Dalil Belhadj, Bernadette España, Alexis Lécu   +3 more
doaj   +1 more source

A study on selective transformation of norbornadiene into fluorinated cyclopentane-fused isoxazolines

Beilstein Journal of Organic Chemistry, 2021
This work presents an examination of the selective functionalization of norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization of commercially available norbornadiene
Zsanett Benke, Attila M. Remete, Loránd Kiss   +2 more
doaj   +1 more source

New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Carbonic anhydrases (CAs) are widespread metalloenzymes which catalyse the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3−) and a proton, relevant in many physiological processes. In the last few years, the involvement of CA activation
Doretta Cuffaro, Riccardo Di Leo, Lidia Ciccone, Alessio Nocentini, Claudiu T. Supuran, Elisa Nuti, Armando Rossello   +6 more
doaj   +1 more source

A Facile Synthesis of Some Bioactive Isoxazoline Dicarboxylic Acids via Microwave-Assisted 1,3-Dipolar Cycloaddition Reaction

Reactions
The microwave-assisted 1,3-dipolar cycloaddition reaction of several aldoximes and dimethyl-2-methylene glutarate in the presence of diacetoxyiodobenzene as an oxidant produced four new isoxazoline-derived dimethyl carboxylates.
Jessica Master, Shekiel Sydney, Harsha Rajapaske, Malek Saffiddine, Vikiana Reyes, Richard W. Denton   +5 more
doaj   +1 more source

P-31 Synthesis of Isoxazoline as a PAM Activator

, 2022
Alzheimer’s disease (AD) is correlated to degeneration of muscarinic acetylcholine receptors (mAChR). Activation of M1 receptor (G protein) with positive allosteric modulator (PAM) has shown to bind to the receptor slowing the degeneration.
Fajardo, Daniel
core  

Halonium Ion Mediated Synthesis of 2‑Halomethylene-3-oxoketoxime Derivatives from Isoxazoline N‑Oxides

, 2016
A protocol for the N-bromosuccinimide (NBS)- and trichloroisocyanuric acid (TCCA)-mediated synthesis of novel 2-halomethylene-3-oxoketoximes via one-pot halogenation/oxidation of isoxazoline N-oxide derivatives is described here.
Veerababurao Kavala (1843219), Ting-Shen Kuo (1431397), Hsiu-Ni Huang (1843201), Ching-Fa Yao (1843216), R. R. Rajawinslin (1915804), Chun-Wei Kuo (1843213), Mustafa J. Raihan (1915801), Chiu-Hui He (1843204)   +7 more
core   +2 more sources

Afoxolaner as a Treatment for a Novel Sarcoptes scabiei Infestation in a Juvenile Potbelly Pig

Frontiers in Veterinary Science, 2020
A 2 months old female Vietnamese potbellied pig presented to a veterinary teaching hospital with a referring complaint of pruritus. A human caretaker of the pig had recently been diagnosed with a Sarcoptes spp. dermatitis.
Joe S. Smith, Joe S. Smith, Darren J. Berger, Sarah E. Hoff, Jeba R. J. Jesudoss Chelladurai, Katy A. Martin, Matthew T. Brewer   +6 more
doaj   +1 more source

Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists

, 2016
Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic substituents at positions α and β to the carboxylate moiety was evaluated.
Douglas G. Batt (1622293), Ruth R. Wexler (1550446), Chu-Biao Xue (2139553), Michael Sworin (3019887), William E. Frietze (3019908), Elizabeth A. Hausner (3019881), Thais M. Sielecki (3019518), Shaker A. Mousa (338877), William F. DeGrado (276486), George Emmett (3002307), Arlene L. Rockwell (3019890), Richard E. Olson (2292958), C. Anne Higley (3019917), Michael J. Orwat (2470096), Thomas M. Reilly (3019911), John J. Roderick (3019902), F. Wayne Rankin (3019896), Martin J. Thoolen (3019884), Lori L. Bostrom (3016791), Jie Liu (15128), John Wityak (519927), Shuaige Wang (3011235), Gary A. Cain (3019899), Susan V. Di Meo (3019893), Adrienne L. Racanelli (3019914), Donald J. Pinto (3019521), A. Ewa Tobin (3019524), George K. Lalka (3019905), Jean Y. Sze (2392798)   +28 more
core   +1 more source

Field trial investigating the efficacy of a long-acting imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®, Elanco) compared to monthly topical fipronil for the chemoprevention of canine tick-borne pathogens in Cambodia

Current Research in Parasitology and Vector-Borne Diseases, 2022
The tropical brown dog tick, Rhipicephalus linnaei, commonly infests canines in the tropics and is an important vector for disease-causing and sometimes lethal pathogens including Babesia spp., Ehrlichia canis, Hepatozoon canis and Anaplasma platys.
Lucas G. Huggins, Mark Stevenson, Zahida Baydoun, Ron Mab, Yulia Khouri, Bettina Schunack, Rebecca J. Traub   +6 more
doaj   +1 more source