Results 81 to 90 of about 4,771 (210)

Synthesis and In Silico Analysis of New Polyheterocyclic Molecules Derived from [1,4]-Benzoxazin-3-one and Their Inhibitory Effect against Pancreatic α-Amylase and Intestinal α-Glucosidase

Molecules
This study focuses on synthesizing a new series of isoxazolinyl-1,2,3-triazolyl-[1,4]-benzoxazin-3-one derivatives 5a–5o. The synthesis method involves a double 1,3-dipolar cycloaddition reaction following a “click chemistry” approach, starting from the ...
Mohamed Ellouz, Aziz Ihammi, Abdellah Baraich, Ayoub Farihi, Darifa Addichi, Saliha Loughmari, Nada Kheira Sebbar, Mohamed Bouhrim, Ramzi A. Mothana, Omar M. Noman, Bruno Eto, Fatiha Chigr, Mohammed Chigr   +12 more
doaj   +1 more source

Steroid [16, 17-c]isoxazoline

Chemical and Pharmaceutical Bulletin, 1964
5'-Methyl-5α-androstano[16, 17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16, 17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and
Noguchi, Shunsaku, Imanishi, Masayuki, Morita, Katsura   +2 more
openaire   +3 more sources

1,3‐Dipolar Cycloaddition of Nitroalkanes as a Tool of DOS/LOS‐Like Strategy for the Synthesis of Isoxazoles and Isoxazolines

ChemistryEurope, Volume 4, Issue 9, September 2026.
A broadly applicable synthetic platform based on a DOS/LOS‐like strategy is implemented for the case of sp3‐enriched isoxazole/isoxazoline building blocks. The method is based on a [3+2] cycloaddition of nitroalkanes and various alkenes or alkynes. The utility of the proposed approach is illustrated by the discovery of JAK2‐selective inhibitors.
Bohdan A. Chalyk, Kostiantyn O. Halos, Anastasiia Grynyova, Bohdan S. Sosunovych, Bohdan V. Vashchenko, Oleksandr Zginnyk, Anna Beshtynarska, Nataliia Shliakhtova, Petro Borysko, Angelina V. Biitseva, Konstantin S. Gavrilenko, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko   +12 more
wiley   +1 more source

Can't outrun recurrence: Long‐term outcomes of treating American black bear sarcoptic mange

The Journal of Wildlife Management, Volume 90, Issue 7, September 2026.
Abstract The growing incidence of sarcoptic mange in American black bears (Ursus americanus) has become a concern for wildlife managers in the eastern United States. Inconsistency in the use of single and multi‐dose treatment approaches makes it difficult to evaluate their effects on post‐release outcomes of mange‐rehabilitated bears, which remain ...
Raquel Francisco, Viviana Berdecia‐Martinez, Marcelo Jorge, Jillian R. Broadhurst, Katherine Martin, Carl Tugend, John Tracey, Karra Pierce, Peach Van Wick, Michael J. Yabsley   +9 more
wiley   +1 more source

Catalytic asymmetric syntheses of isoxazoline-N-oxides under phase-transfer conditions. [PDF]

, 2011
Catalytic asymmetric syntheses of various isoxazoline-N-oxides have been accomplished by asymmetric phase-transfer conjugate addition of bromomalonate to nitroolefins and subsequent ring-closing O ...
Taichi Kano, Sunhwa Song, Maruoka, Keiji, Song, Sunhwa, Keiji Maruoka, Akihiro Yamamoto, Kano, Taichi, Yamamoto, Akihiro   +7 more
core   +1 more source

Divergent synthesis of polysubstituted isoxazoles, isoxazoline N-oxides, and dihydroisoxazoles by a one-pot cascade reaction

, 2017
An efficient one-pot synthesis of a new class of 3,4,5-trisubstituted isoxazoline N-oxides/isoxazoles and dihydroisoxazoles is developed by a green approach from aromatic and aliphatic aldehydes by controlling the reaction conditions.
Tanyeli, Cihangir, ŞAHİN, Ertan, Rouf, Abdul   +2 more
core   +1 more source

Synthesis, Antimicrobial Evaluation, and Docking Study of Some New Isoxazoline Derivatives Derived from Chalcones

Journal of the Turkish Chemical Society, Section A: Chemistry
New 2-Isoxazoline derivatives containing furan moieties were synthesized from chalcones as starting materials, followed by antimicrobial activity. Chalcones were synthesized by reacting p-methoxy acetophenone or 3,4-(methylenedioxy)acetophenone with ...
Abdulkadir Mohammed Noori Jassim, Inas Salim, Ahmed Mutanabbi Abdula   +2 more
doaj   +1 more source

Suspected neurological toxicity after oral application of fluralaner (Bravecto®) in a Kooikerhondje dog

BMC Veterinary Research, 2019
Background Although the new isoxazoline drug fluralaner (Bravecto®) is generally well tolerated in dogs, adverse drug reactions involving neurological dysfunction occurred in individual dogs.
Daniela Gaens, Christoph Rummel, Martin Schmidt, Melanie Hamann, Joachim Geyer   +4 more
doaj   +1 more source

2-Methoxy-4-[5-(2-oxo-1,3-dioxolan-4-yl)-4,5-dihydroisoxazol-3-yl]phenyl 4-n-decyloxybenzoate

Molbank
This study addresses the synthesis of a new liquid crystalline compound featuring a 3,5-disubstituted isoxazoline and a 1,3-dioxolan-2-one ring, and renewable aromatic building blocks derived from vanilin and benzoic acid.
Itamar Luís Gonçalves, Aloir Antonio Merlo, Bruna Thatise Batistel, Leonardo Rossner Wbatuba, Henrique de Aguiar Mello   +4 more
doaj   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj