Results 81 to 90 of about 8,655 (241)

Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists

, 2016
Using isoxazoline XR299 (1a) as a starting point for the design of highly potent, long-duration GPIIb/IIIa antagonists, the effect of placing lipophilic substituents at positions α and β to the carboxylate moiety was evaluated.
Douglas G. Batt (1622293), Ruth R. Wexler (1550446), Chu-Biao Xue (2139553), Michael Sworin (3019887), William E. Frietze (3019908), Elizabeth A. Hausner (3019881), Thais M. Sielecki (3019518), Shaker A. Mousa (338877), William F. DeGrado (276486), George Emmett (3002307), Arlene L. Rockwell (3019890), Richard E. Olson (2292958), C. Anne Higley (3019917), Michael J. Orwat (2470096), Thomas M. Reilly (3019911), John J. Roderick (3019902), F. Wayne Rankin (3019896), Martin J. Thoolen (3019884), Lori L. Bostrom (3016791), Jie Liu (15128), John Wityak (519927), Shuaige Wang (3011235), Gary A. Cain (3019899), Susan V. Di Meo (3019893), Adrienne L. Racanelli (3019914), Donald J. Pinto (3019521), A. Ewa Tobin (3019524), George K. Lalka (3019905), Jean Y. Sze (2392798)   +28 more
core   +1 more source

Synthesis and Study Biological Activity of Some New Isoxazoline and Pyrazoline derivatives

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
   This work involves synthesis of novel Schiff bases derivatives contining isoxazoline or pyrazoline units starting with chalcons . 4-Aminoacetophenone was reacted with 3-nitrobenzaldehyde in basic medium giving chalcone [I] by claisen-schemidt ...
Muna S. Al-Rawi, Jumbad H. Tomma, Rana M. Abdullah   +2 more
doaj  

1,3-Dipolar cycloaddition, HPLC enantioseparation and docking studies of saccharin/isoxazole and saccharin/isoxazoline derivatives as selective carbonic anhydrase IX and XII inhibitors.

Journal of Medicinal Chemistry, 2020
Two series of saccharin/isoxazole and saccharin/isoxazoline hybrids were synthesised by 1,3-dipolar cycloaddition. The new compounds showed to be endowed with potent and selective inhibitory activity against the cancer-related human carbonic anhydrase ...
Melissa D'Ascenzio, D. Secci, S. Carradori, S. Zara, Paolo Guglielmi, R. Cirilli, M. Pierini, G. Poli, T. Tuccinardi, A. Angeli, C. Supuran   +10 more
semanticscholar   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Fecal elimination of fluralaner in different carnivore species after oral administration

Frontiers in Veterinary Science
Fluralaner is a recent external parasiticide, first of a new class of drugs (isoxazoline parasiticides). It is widely used in companion animals both for its wide spectrum (fleas, ticks and other mites) but also for its ease of use (oral tablets given ...
Philippe Jacques Berny, Dalil Belhadj, Bernadette España, Alexis Lécu   +3 more
doaj   +1 more source

3,5-Bis(4-methoxyphenyl)-4,5-dihydroisoxazole

Acta Crystallographica Section E, 2011
In the title compound, C17H17NO3, the five-membered isoxazoline ring adopts an envelope conformation with the chiral C atom at the flap position and 0.133 (2) Å out of the mean plane formed by the other four atoms.
S. Samshuddin, Ray J. Butcher, Mehmet Akkurt, B. Narayana, H. S. Yathirajan   +4 more
doaj   +1 more source

Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

Scientific Reports, 2021
An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically ...
Ting-Bi Hua, Cheng-Xiong Liu, Wei-Min Hu, Long Wang, Qing-Qing Yang   +4 more
doaj   +1 more source

Susceptibility of Phthorimaea absoluta (Meyrick) (Lepidoptera: Gelechiidae) to novel and established insecticides in Brazil: resistance survey, baseline, and implications for management

Pest Management Science, Volume 82, Issue 6, Page 5662-5671, June 2026.
Baseline susceptibility of Phthorimaea absoluta to novel insecticides isocycloseram and tolfenpyrad was established in Brazil. Diagnostic doses were proposed for early resistance detection. Early tolfenpyrad tolerance and abamectin‐driven cross‐tolerance to isocycloseram via oxidases highlight cross‐resistance risks, emphasizing the need for routine ...
Vitor Quintela, Teófilo P Langa, José VCR Dantas, Marcos de Oliveira, Herbert AA Siqueira   +4 more
wiley   +1 more source

Molybdenum-Mediated Cleavage Reactions of Isoxazoline Rings Fused in Bicyclic Frameworks

, 2002
The molybdenum-mediated cleavage reactions of isoxazoline rings fused in bicyclic frameworks were investigated. A tandem N−O bond cleavage-retro aldol reaction of an isoxazoline ring fused in a bicyclic framework led to the cleavage of the bicyclic ...
Tam, William, Geoffrey K. Tranmer, Tranmer, Geoffrey K., William Tam   +3 more
core   +1 more source

A Facile Synthesis of Some Bioactive Isoxazoline Dicarboxylic Acids via Microwave-Assisted 1,3-Dipolar Cycloaddition Reaction

Reactions
The microwave-assisted 1,3-dipolar cycloaddition reaction of several aldoximes and dimethyl-2-methylene glutarate in the presence of diacetoxyiodobenzene as an oxidant produced four new isoxazoline-derived dimethyl carboxylates.
Jessica Master, Shekiel Sydney, Harsha Rajapaske, Malek Saffiddine, Vikiana Reyes, Richard W. Denton   +5 more
doaj   +1 more source