Results 71 to 80 of about 4,771 (210)

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari   +3 more
wiley   +1 more source

5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity

open access: yes, 2005
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline has been synthesized by reacting benzonitrile oxide with the enolate ion of methyl vinyl ketone. From 5-hydroxy-5-vinyl-2-isoxazoline, 5-vinylisoxazole was then quantitatively obtained by dehydration–aromatization
DI NUNNO L   +3 more
core   +1 more source

Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

open access: yesScientific Reports, 2021
An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically ...
Ting-Bi Hua   +4 more
doaj   +1 more source

Advances in Agricultural Applications of Lignans

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
This graphical abstract presents lignans as green alternatives to chemical pesticides and antibiotics for agriculture and veterinary use. It illustrates their applications in plant protection (antifungal, insecticidal, herbicidal, fruit preservation) and aquaculture, classifies lignan subtypes from classic to complex forms, highlights limitations like ...
Kaida Li   +5 more
wiley   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

open access: yesAdvanced Materials, Volume 38, Issue 52, 16 September 2026.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi   +3 more
wiley   +1 more source

Solution-phase synthesis of novel Δ2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties

open access: yes, 2003
The synthesis of novel imidazolyl substituted δ2-isoxazoline libraries are currently of high interest. We report here in the full details of a study leading to the synthesis and antifungal activities of 3-(-2-butyl-4-chloro-1H-imidazolyl)-substituted δ2 ...
Mantelingu, K.   +4 more
core   +1 more source

Bicyclic Pyrrolidine-Isoxazoline γ Amino Acid: A Constrained Scaffold for Stabilizing α-Turn Conformation in Isolated Peptides

open access: yesFrontiers in Chemistry, 2019
Unnatural amino acids have tremendously expanded the folding possibilities of peptides and peptide mimics. While α,α-disubstituted and β-amino acids are widely studied, γ-derivatives have been less exploited.
Francesco Oliva   +5 more
doaj   +1 more source

Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities

open access: yesResults in Chemistry, 2020
A greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives.
Bhaskar Chakraborty, Esmita Chettri
doaj   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan   +4 more
wiley   +1 more source

A NEW PEPTIDE-BOND SURROGATE - 2-ISOXAZOLINE IN PSEUDODIPEPTIDE CHEMISTRY

open access: yes, 1992
The 2-isoxazoline ring has been incorporated as a new peptide bond surrogate into pseudodipeptide.
KEUM, GC   +9 more
core   +1 more source

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