Results 91 to 100 of about 8,655 (241)

A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime

Beilstein Journal of Organic Chemistry, 2013
Functionalized 3-trifluoromethyl-2-isoxazolines and 3-trifluoromethylisoxazoles were easily prepared from trifluoromethyl aldoxime 2 under mild conditions by using DIB as oxidant.
Raoni S. B. Gonçalves, Michael Dos Santos, Guillaume Bernadat, Danièle Bonnet-Delpon, Benoit Crousse   +4 more
doaj   +1 more source

Molybdenum-Mediated Cleavage Reactions of Isoxazoline Rings Fused in Bicyclic Frameworks

, 2016
The molybdenum-mediated cleavage reactions of isoxazoline rings fused in bicyclic frameworks were investigated. A tandem N−O bond cleavage-retro aldol reaction of an isoxazoline ring fused in a bicyclic framework led to the cleavage of the bicyclic ...
Geoffrey K. Tranmer (2520547), William Tam (640256)   +1 more
core   +1 more source

Stereoselective Synthesis of 1-Nitrobicyclo[3.1.0]hexanes and Fused Isoxazoline-N-oxides from Primary Nitro Compounds

, 2016
The one-step preparation of 1-nitrobicyclo[3.1.0]­hexane and bicycloisoxazoline-N-oxide was readily achieved from conjugate adducts of nitro alkenes and allylmalonates by treatment with Ag2O and iodine under basic conditions.
Akio Kamimura (1754224), Ryota Takeuchi (2108365), Kosuke Ikeda (2108362), Michinori Sumimoto (1848757), Takaaki Moriyama (2108359)   +4 more
core   +3 more sources

Bicyclic Pyrrolidine-Isoxazoline γ Amino Acid: A Constrained Scaffold for Stabilizing α-Turn Conformation in Isolated Peptides

Frontiers in Chemistry, 2019
Unnatural amino acids have tremendously expanded the folding possibilities of peptides and peptide mimics. While α,α-disubstituted and β-amino acids are widely studied, γ-derivatives have been less exploited.
Francesco Oliva, Raffaella Bucci, Lucia Tamborini, Stefano Pieraccini, Andrea Pinto, Sara Pellegrino   +5 more
doaj   +1 more source

Mechanochemical synthesis of some heterocyclic molecules using Sonogashira cross-coupling reaction and their anticancer activities

Results in Chemistry, 2020
A greener strategy for the synthesis of some functionalized heterocycles have been developed using Sonogashira cross-coupling reaction of furfural derived isoxazolidine and isoxazoline derivatives.
Bhaskar Chakraborty, Esmita Chettri
doaj   +1 more source

Synthesis and In Silico Analysis of New Polyheterocyclic Molecules Derived from [1,4]-Benzoxazin-3-one and Their Inhibitory Effect against Pancreatic α-Amylase and Intestinal α-Glucosidase

Molecules
This study focuses on synthesizing a new series of isoxazolinyl-1,2,3-triazolyl-[1,4]-benzoxazin-3-one derivatives 5a–5o. The synthesis method involves a double 1,3-dipolar cycloaddition reaction following a “click chemistry” approach, starting from the ...
Mohamed Ellouz, Aziz Ihammi, Abdellah Baraich, Ayoub Farihi, Darifa Addichi, Saliha Loughmari, Nada Kheira Sebbar, Mohamed Bouhrim, Ramzi A. Mothana, Omar M. Noman, Bruno Eto, Fatiha Chigr, Mohammed Chigr   +12 more
doaj   +1 more source

Steroid [16, 17-c]isoxazoline

Chemical and Pharmaceutical Bulletin, 1964
5'-Methyl-5α-androstano[16, 17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16, 17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and
Noguchi, Shunsaku, Imanishi, Masayuki, Morita, Katsura   +2 more
openaire   +3 more sources

Synthesis, Antimicrobial and Antioxidant Activities of 2-Isoxazoline Derivatives

Molecules, 2020
A series of derivatives of trans-3-(2,4,6-trimethoxyphenyl)4,5-dihydroisoxazolo-4,5-bis[carbonyl-(4′phenyl)thiosemicarbazide (9) and of trans-3-(2,4,6-trimethoxyphenyl)-4,5-dihydro isoxazolo-4,5-bis(aroylcarbohydrazide) (10a–c) were synthesized from ...
A. Alshamari, Mahmoud A. Al-Qudah, F. Hamadeh, Lo'ay A. Al-Momani, S. Abu-Orabi   +4 more
semanticscholar   +1 more source

Synthesis of Isoxazoline Derivatives through Boulton–Katritzky Rearrangement of 1,2,4-Oxadiazoles

, 2013
The base-induced rearrangement of 1,2,4-oxadiazoles into isoxazoline derivatives is reported. This represents the first example of a three-atom side-chain rearrangement that involves a saturated CCO side chain at C-3 of the oxadiazole.
PALUMBO PICCIONELLO, Antonio, GUARCELLO, Annalisa, BUSCEMI, Silvestre, PACE, Andrea   +3 more
core   +1 more source

Cycloaddition Reactions of Benzonorbornadiene and Homonorbornadiene: New Isoxazoline and Pyridazine Derivatives

, 2018
Ten new isoxazoline derivatives were synthesized from the reactions of benzonorbornadiene and homonorbornadiene derivatives with nitrile oxides formed from benzaldehyde and 4-substituted benzaldehyde.
Tutar, Ahmet, Yadigar Adiloglu, Ertan Sahin, Abdullah Menzek, MENZEK, Abdullah, ŞAHİN, Ertan, Ahmet Tutar, Adiloglu, Yadigar   +7 more
core   +1 more source