Results 11 to 20 of about 239,878 (262)

One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines

Molecules, 2004
The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be
Aïcha Derdour, Michel Vaultier, Amar Saad   +2 more
doaj   +2 more sources

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity. [PDF]

Medchemcomm, 2018
By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.
Roscales S, Bechmann N, Weiss DH, Köckerling M, Pietzsch J, Kniess T.   +5 more
europepmc   +2 more sources

MnVI-NP–Catalyzed Generation of Nitrile Oxides: Easy Access to Isoxazolines and Isoxazoles via Stereoselective 1,3-Dipolar Cyclo­addition Reactions

SynOpen, 2022
The versatility and effectiveness of MnVI-NPs as a catalyst is examined for the generation of nitrile oxides from aldoximes and subsequent 1,3-dipolar cycloaddition reactions.
Yasmin Saima, Saikat Khamarui
doaj   +1 more source

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

Ultrasonics Sonochemistry, 2021
In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA)
Aicha Talha, Cécile Favreau, Maxence Bourgoin, Guillaume Robert, Patrick Auberger, Lahcen EL Ammari, Mohamed Saadi, Rachid Benhida, Anthony R. Martin, Khalid Bougrin   +9 more
doaj   +1 more source

Studies on the [2+3] cycloaddition reaction of nitrile oxides to abietic acid esters [PDF]

Journal of the Serbian Chemical Society, 2019
[2+3] Dipolar cycloadditions of aromatic nitrile oxides to abietic acid esters were investigated. The reactions showed complete site selectivity and regioselectivity, while the stereoselectivity depended on the structures of the dipolarophiles.
Gucma Mirosław, Gołębiewski Marek W., Żelechowski Krzysztof, Krawczyk Maria   +3 more
doaj   +1 more source

Mechanochemical Dimerization of Aldoximes to Furoxans

Molecules, 2022
Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis.
Run-Kai Fang, Kuan Chen, Chuang Niu, Guan-Wu Wang   +3 more
doaj   +1 more source

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently [PDF]

, 2019
GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. While most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein’s catalytic selenocysteine ...
Richard A., Ruberto, John, Eaton, John Eaton (6248192), Stuart Schreiber (5921467), Anneke, Kramm, Anneke Kramm (6253868), Vasanthi S. Viswanathan (6253891), Stuart, Schreiber, Vasanthi S., Viswanathan, Richard A. Ruberto (6253842)   +9 more
core   +2 more sources

A Weinreb Nitrile Oxide and Nitrone for Cycloaddition. [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ajit K, Parhi, Richard W, Franck
openaire   +2 more sources

Metal-catalyzed 1,3-dipolar cycloaddition reactions of nitrile oxides [PDF]

, 2018
In the present review advances in the metal-catalyzed 1,3-dipolar cycloaddition reactions of nitrile oxides, mainly in the last decade, will be presented and discussed. An overview on the structure, preparation, dimerization and related reactions as well
Roscales García, Silvia, Silvia Roscales, Joaquín Plumet, Plumet, Joaquín   +3 more
core   +1 more source

Reactions of 5-Aroylmethylene-3-benzyl-4-oxo-2-thioxo-1,3-thiazolidines with Nitrile Oxides

Molecules, 2001
E,Z-5-Aroylmethylene-3-benzyl-4-oxo-2-thioxo-1,3-thiazolidines (3a-c) react with 4-methoxy and 4-chlorophenylnitrile oxides (4a and b) in pyridine solution to afford one or more of the following compounds: Z-3, Z-2,4-dioxo analogues 5 and 3,6-diaryl-1,4 ...
Ahmed S. A. Youssef, Kamal A. Kandeel
doaj   +1 more source