Results 1 to 10 of about 3,169 (181)
Bioactive Oxadiazoles 3.0. [PDF]
Int J Mol SciHeterocycles are fundamental moieties for the construction of new compounds with perspective applications ranging from drugs to materials [...]
Palumbo Piccionello A.
europepmc +4 more sources
3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM [PDF]
PharmaceuticalsBackground: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich +7 more
doaj +2 more sources
Bioscience Journal, 2022 In recent years, investigations in the field of oxadiazoles have been intensified due to their numerous therapeutic uses. Oxadiazoles are a class of compounds that exhibit several biological applications, citing antimicrobial, anti-inflammatory, anti ...
Josefa Aqueline da Cunha Lima +6 more
doaj +1 more source
Synthesis of 2,5-Dialkyl-1,3,4-oxadiazoles Bearing Carboxymethylamino Groups
Molecules, 2022 A series of new symmetrical 2,5-dialkyl-1,3,4-oxadiazoles containing substituted alkyl groups at the terminal positions with substituents, such as bromine, isopropyloxycarbonylmethylamino, and carboxymethylamino, were successfully synthesized.
Marcin Łuczyński +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2021 Acetylene derivatives of 1,2,4-oxadiazoles, i.e., 5-(2-arylethynyl)-3-aryl-1,2,4-oxadiazoles, have been obtained, for the first time reported, from 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles by their bromination at the carbon–carbon double bond followed ...
Andrey I. Puzanov +6 more
doaj +1 more source
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021 Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area of study in medical chemistry. They are present in a variety of drugs, vitamins and biologically active compounds. Over two decades, 1,
Yu. V. Karpenko +2 more
doaj +1 more source
Synthesis and Pharmacological Characterization of Metronidazole-Oxadiazole Derivatives [PDF]
Iranian Journal of Medical Sciences, 2023 Background: The use of antibiotics with or without prescription is increasing worldwide. With certain limitations, metronidazole (MTZ) is extensively used as an antibacterial and antiparasitic drug.
Mohsin Mohammed, Nadia Haj
doaj +1 more source
The oxadiazole antibacterials [PDF]
Current Opinion in Microbiology, 2016 The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
Jeshina, Janardhanan +2 more
openaire +2 more sources
Synthesis and characterization of new phthalimides and succinimides substituted with 1,3,4-oxadiazole ring [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2012 A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2- amino-1,3,4-oxadiazoles by oxidative cyclization of substituted ...
Ahlam Marouf Al-Azzawi +1 more
doaj +1 more source
Cu(OH)x: Clay Catalyst Promoted Synthesis of 4,5-dihydro-1,2,4-oxadiazole at Room Temperature
Orbital: The Electronic Journal of Chemistry, 2017 An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature.
Bashir Ahmad Dar +3 more
doaj +3 more sources