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The oxadiazole antibacterials [PDF]

Current Opinion in Microbiology, 2016
The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
Jeshina, Janardhanan, Mayland, Chang, Shahriar, Mobashery   +2 more
openaire   +2 more sources

Cu(OH)x: Clay Catalyst Promoted Synthesis of 4,5-dihydro-1,2,4-oxadiazole at Room Temperature

Orbital: The Electronic Journal of Chemistry, 2017
An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature.
Bashir Ahmad Dar, Zahed Zaheer, Samreen Fatema, Mazahar Farooqui   +3 more
doaj   +3 more sources

SET activation of nitroarenes by 2-azaallyl anions as a straightforward access to 2,5-dihydro-1,2,4-oxadiazoles

Nature Communications, 2021
Oxadiazoles are five-membered ring heterocycles comprising an oxygen and two nitrogens, and those with the 1,2,4-oxadiazole skeleton are of interest due to their prevalence in biologically active compounds.
Dong Zou, Lishe Gan, Fan Yang, Huan Wang, Youge Pu, Jie Li, Patrick J. Walsh   +6 more
doaj   +1 more source

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2

Molecules, 2021
A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes.
Oksana V. Salomatina, Nadezhda S. Dyrkheeva, Irina I. Popadyuk, Alexandra L. Zakharenko, Ekaterina S. Ilina, Nina I. Komarova, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho   +9 more
doaj   +1 more source

Metal-free hydroarylation of the side chain carbon–carbon double bond of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles in triflic acid

Beilstein Journal of Organic Chemistry, 2017
The metal-free reaction of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles with arenes in neat triflic acid (TfOH, CF3SO3H), both under thermal and microwave conditions, leads to 5-(2,2-diarylethyl)-3-aryl-1,2,4-oxadiazoles.
Anna S. Zalivatskaya, Dmitry S. Ryabukhin, Marina V. Tarasenko, Alexander Yu. Ivanov, Irina A. Boyarskaya, Elena V. Grinenko, Ludmila V. Osetrova, Eugeniy R. Kofanov, Aleksander V. Vasilyev   +8 more
doaj   +1 more source

Electrocyclization of Semicarbazone; A Novel Route of Green Synthesis of 2,5-Disubstituted-1,3,4-Oxadiazoles

International Journal of Electrochemical Science, 2011
The anodic oxidation of a number of arylsemicarbazides derivatives (I) has been examined in acetonitril containing lithium perchlorate (LiClO4) as a supporting electrolyte (20g/l).
Benmekhbi Lotfi, Bencharif Mustafa, Bencharif Leila, Mosbah Salima   +3 more
doaj   +1 more source

Microwave-Assisted Synthesis of Unsymmetrical 5-Phenyl-1,3,4-oxadiazoles Containing Bis(carboxymethyl)amino Group

Applied Sciences, 2023
New derivatives of 5-phenyl-1,3,4-oxadiazole substituted at position 2 with (bromomethyl)phenyl or bromoalkyl groups were obtained via microwave-assisted cyclodehydration of unsymmetrical N,N′-diacylhydrazines.
Marcin Łuczyński, Agnieszka Kudelko
doaj   +1 more source

Therapeutic potential of oxadiazole or furadiazole containing compounds

BMC Chemistry, 2020
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as ...
Ankit Siwach, Prabhakar Kumar Verma
doaj   +1 more source

Cu(OH)x-clay catalyst promoted synthesis of 4,5-dihydro-1,2,4-oxadiazole at room temperature

Green Processing and Synthesis, 2018
An easy and efficient scheme is described and designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-clay heterogeneous catalyst at room temperature.
Dar Bashir Ahmad, Zaheer Zahed, Fatema Samreen, Farooqui Mazahar   +3 more
doaj   +1 more source

2-(4-Bromophenoxy)propanohydrazide

Acta Crystallographica Section E, 2009
The title compound, C9H11BrN2O2, is an important intermediate for the synthesis of heterocyclic compounds such as azoles, 2,5-disubstituted-1,3,4-oxadiazoles and 5-substituted 2-mercapto-1,3,4-oxadiazoles. The bromophenoxy group subtends a dihedral angle
Shahid Hameed, Masahiro Ebihara, M. Khawar Rauf, Tashfeen Akhtar   +3 more
doaj   +1 more source