Results 1 to 10 of about 5,507 (218)

Synthesis of 2,5-Dialkyl-1,3,4-oxadiazoles Bearing Carboxymethylamino Groups

Molecules, 2022
A series of new symmetrical 2,5-dialkyl-1,3,4-oxadiazoles containing substituted alkyl groups at the terminal positions with substituents, such as bromine, isopropyloxycarbonylmethylamino, and carboxymethylamino, were successfully synthesized.
Marcin Łuczyński, Kornelia Kubiesa, Agnieszka Kudelko   +2 more
doaj   +2 more sources

2:1 Adducts Arising from Reactions between Benzynes and 1,3,4-Oxadiazoles. [PDF]

Org Lett
2:1 adducts arise from the reaction of 2,5-diaryl-1,3,4-oxadiazoles and benzynes generated from the hexadehydro-Diels–Alder (HDDA) reaction. Density functional theory computations support a mechanistic manifold that includes a concerted SNAr process ...
Guzman AL, Kevorkian PV, Hoye TR.
europepmc   +3 more sources

Synthesis and structure–activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase

Bioorganic and Medicinal Chemistry, 2009
International audienceA series of per-O-benzoylated 5-beta-D-glucopyranosyl-2-substituted-1,3,4-oxadiazoles was prepared by acylation of the corresponding 5-(beta-D-glucopyranosyl)tetrazole.
Marietta Tóth, Sándor Kun, Eva Bokor   +2 more
exaly   +2 more sources

A novel synthesis of 1,2,4-oxadiazoles and isoxazoles

Tetrahedron, 2014
A novel synthesis of 1,2,4-oxadiazoles and isoxazoles is described by utilizing the reactions between amidoximes and alpha,beta-alkynic aldehydes and/or ketones.
Arif Kivrak, Metin Zora
exaly   +2 more sources

3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM [PDF]

Pharmaceuticals
Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich, Ivan O. Maslov, Olga G. Kirichenko, Sergey V. Shorshnev, Maxim A. Gureev, Fedor M. Dolgushin, Yuri B. Porozov, Vladimir M. Trukhan   +7 more
doaj   +2 more sources

Ultrasound-promoted synthesis of 3-trichloromethyl-5-alkyl(aryl)-1,2,4-oxadiazoles

Ultrasonics Sonochemistry, 2011
The alternative synthesis of 12 1,2,4-oxadiazoles using ultrasound irradiation from trichloroacetoamidoxime and acyl chlorides is reported. Seven of them are novel compounds.
Wilson Cunico, Claudio M P Pereira, Rogerio Antonio Freitag   +2 more
exaly   +2 more sources

SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2012
In recent years 1,3,4-oxadiazoles have received considerable attention due to their wide range of biological activities and practical importance. They form an important class of fi ve-member heterocyclic compounds with a variety of derivatives.
Z. Ribcovskaia, F. Macaev
doaj   +1 more source

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice

Bioorganic and Medicinal Chemistry, 2012
We recently showed that oxadiazoles have anti-Trypanosoma cruzi activity at micromolar concentrations. These compounds are easy to synthesize and show a number of clear and interpretable structure-activity relationships (SAR), features that make them ...
JOSÉ Mauricio dos Santos Filho, Diogo Rodrigo Magalhães Moreira, CARLOS Alberto de Simone   +2 more
exaly   +2 more sources

Synthesis, antimicrobial evaluation and in silico studies of the (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles

Bioscience Journal, 2022
In recent years, investigations in the field of oxadiazoles have been intensified due to their numerous therapeutic uses. Oxadiazoles are a class of compounds that exhibit several biological applications, citing antimicrobial, anti-inflammatory, anti ...
Josefa Aqueline da Cunha Lima, Erick Caique Santos Costa, Giselle Barbosa Bezerra, Jadson de Farias Silva, Rodrigo Ribeiro Alves Caiana, Joao Rufino de Freitas Filho, Juliano Carlo Rufino Freitas   +6 more
doaj   +1 more source

Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions

Beilstein Journal of Organic Chemistry, 2021
Acetylene derivatives of 1,2,4-oxadiazoles, i.e., 5-(2-arylethynyl)-3-aryl-1,2,4-oxadiazoles, have been obtained, for the first time reported, from 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles by their bromination at the carbon–carbon double bond followed ...
Andrey I. Puzanov, Dmitry S. Ryabukhin, Anna S. Zalivatskaya, Dmitriy N. Zakusilo, Darya S. Mikson, Irina A. Boyarskaya, Aleksander V. Vasilyev   +6 more
doaj   +1 more source