Results 1 to 10 of about 6,176 (169)

A new and efficient synthesis of substituted 2-amino-1,3,4-oxadiazoles from isothiocyanates and hydrazides [PDF]

BMC Chemistry
1,3,4-Oxadiazoles are privileged heterocyclic scaffolds with broad bioactivities, holding significant importance in pharmaceutical and agrochemical discovery.
Lei Wu, Haiyign Tian, Yuying Zhang, Wenjing Ma, Qi Zhang, Ruiling Chen, Xiuling Chen   +6 more
doaj   +2 more sources

Synthesis of 2,5-Dialkyl-1,3,4-oxadiazoles Bearing Carboxymethylamino Groups

Molecules, 2022
A series of new symmetrical 2,5-dialkyl-1,3,4-oxadiazoles containing substituted alkyl groups at the terminal positions with substituents, such as bromine, isopropyloxycarbonylmethylamino, and carboxymethylamino, were successfully synthesized.
Marcin Łuczyński, Kornelia Kubiesa, Agnieszka Kudelko   +2 more
doaj   +2 more sources

Functionalized Nitrile Oxides and Their Synthetic Equivalents: Recent Advances in Generation Methods and Synthetic Applications [PDF]

Molecules
Functionalized nitrile oxides have attracted increasing attention because the incorporated functional groups not only influence cycloaddition reactivity but also provide valuable handles for subsequent molecular diversification.
Nagatoshi Nishiwaki
doaj   +2 more sources

Synthesis, antimicrobial evaluation and in silico studies of the (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles

Bioscience Journal, 2022
In recent years, investigations in the field of oxadiazoles have been intensified due to their numerous therapeutic uses. Oxadiazoles are a class of compounds that exhibit several biological applications, citing antimicrobial, anti-inflammatory, anti ...
Josefa Aqueline da Cunha Lima, Erick Caique Santos Costa, Giselle Barbosa Bezerra, Jadson de Farias Silva, Rodrigo Ribeiro Alves Caiana, Joao Rufino de Freitas Filho, Juliano Carlo Rufino Freitas   +6 more
doaj   +1 more source

Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions

Beilstein Journal of Organic Chemistry, 2021
Acetylene derivatives of 1,2,4-oxadiazoles, i.e., 5-(2-arylethynyl)-3-aryl-1,2,4-oxadiazoles, have been obtained, for the first time reported, from 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles by their bromination at the carbon–carbon double bond followed ...
Andrey I. Puzanov, Dmitry S. Ryabukhin, Anna S. Zalivatskaya, Dmitriy N. Zakusilo, Darya S. Mikson, Irina A. Boyarskaya, Aleksander V. Vasilyev   +6 more
doaj   +1 more source

Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5-disubstituted 1,3,4-oxadiazoles (Part 2)

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area of study in medical chemistry. They are present in a variety of drugs, vitamins and biologically active compounds. Over two decades, 1,
Yu. V. Karpenko, S. M. Kulish, N. А. Al Halaf   +2 more
doaj   +1 more source

Synthesis and Pharmacological Characterization of Metronidazole-Oxadiazole Derivatives [PDF]

Iranian Journal of Medical Sciences, 2023
Background: The use of antibiotics with or without prescription is increasing worldwide. With certain limitations, metronidazole (MTZ) is extensively used as an antibacterial and antiparasitic drug.
Mohsin Mohammed, Nadia Haj
doaj   +1 more source

Synthesis and characterization of new phthalimides and succinimides substituted with 1,3,4-oxadiazole ring [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2- amino-1,3,4-oxadiazoles by oxidative cyclization of substituted ...
Ahlam Marouf Al-Azzawi, Hiba Kadhum Yaseen   +1 more
doaj   +1 more source

Cu(OH)x: Clay Catalyst Promoted Synthesis of 4,5-dihydro-1,2,4-oxadiazole at Room Temperature

Orbital: The Electronic Journal of Chemistry, 2017
An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature.
Bashir Ahmad Dar, Zahed Zaheer, Samreen Fatema, Mazahar Farooqui   +3 more
doaj   +3 more sources

SET activation of nitroarenes by 2-azaallyl anions as a straightforward access to 2,5-dihydro-1,2,4-oxadiazoles

Nature Communications, 2021
Oxadiazoles are five-membered ring heterocycles comprising an oxygen and two nitrogens, and those with the 1,2,4-oxadiazole skeleton are of interest due to their prevalence in biologically active compounds.
Dong Zou, Lishe Gan, Fan Yang, Huan Wang, Youge Pu, Jie Li, Patrick J. Walsh   +6 more
doaj   +1 more source