Results 1 to 10 of about 31,516 (214)

Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery [PDF]

Pharmaceuticals, 2020
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities.
Janusz Rachon, Konrad Kubiński, Mateusz Dasko   +2 more
exaly   +9 more sources

Reactions of 1,2,4‐Oxadiazole[4,5‐a]piridinium Salts with Alcohols: the Synthesis of Alkoxybutadienyl 1,2,4‐Oxadiazoles [PDF]

ChemistryOpen, 2020
1,2,4‐Oxadiazole[4,5‐a]piridinium salts add alcohols and alkoxides to undergo electrocyclic ring opening affording alkoxybutadienyl 1,2,4‐oxadiazole derivatives.
Dr. Mattia Moiola, Dr. Marco Leusciatti, Prof. Dr. Paolo Quadrelli   +2 more
doaj   +7 more sources

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their ...
Wei-Dong Jia, Ming Bian
exaly   +4 more sources

Electrocyclic Ring‐Opening of 1,2,4‐Oxadiazole[4,5‐a]piridinium Chloride: a New Route to 1,2,4‐Oxadiazole Dienamino Compounds [PDF]

ChemistryOpen, 2019
1,2,4‐Oxadiazole[4,5‐a]piridinium chloride adds nucleophiles to undergo electrocyclic ring opening affording 1,2,4‐oxadiazole dienamino derivatives. These pyridinium salts represent a special class of Zincke salts that are prone to rearrange when treated
Dr. Stefano Carella, Dr. Misal Giuseppe Memeo, Prof. Paolo Quadrelli   +2 more
doaj   +3 more sources

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives [PDF]

Biochemistry and Biophysics Reports
Melanoma is the most aggressive and lethal type of skin cancer, responsible for approximately 60,000 deaths annually. The main strategy for treating melanoma is surgery to completely remove the lesion and its margins.
Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete   +9 more
doaj   +2 more sources

Design, synthesis, and biological activity of novel 1,2,4-oxadiazole derivatives [PDF]

BMC Chemistry, 2020
Background Plant diseases seriously threaten food security, it is urgent to discover efficient and low-risk chemical pesticides. 1,2,4-Oxadiazole derivatives exhibit broad spectrum of agricultural biological activities.
Lingzhi Zhu, Huanan Zeng, Dan Liu, Yun Fu, Qiong Wu, Baoan Song, Xiuhai Gan   +6 more
doaj   +2 more sources

5-Nitrotetrazol and 1,2,4-Oxadiazole Methylene-Bridged Energetic Compounds: Synthesis, Crystal Structures and Performances [PDF]

Molecules, 2021
A new structural type for melt cast materials was designed by linking nitrotetrazole ring with 1,2,4-oxadiazole through a N-CH2-C bridge for the first time. Three N-CH2-C linkage bridged energetic compounds, including 3-((5-nitro-2H-tetrazol-2-yl) methyl)
Jiarong Zhang, Fuqiang Bi, Zhi Yang, Qi Xue, Bozhou Wang   +4 more
doaj   +2 more sources

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review [PDF]

Results in Chemistry
1,2,4-Oxadiazole derivatives, a prominent class of nitrogen-containing heterocycles, have gained considerable attention recently due to their broad spectrum of biological activities.
Hussam Elddin Nabeih Khasawneh, Ali Abdulrazzaq Abdulhussein Alrikabi, Amran M. AL-Erjan, Mustafa Jawad Kadham, Raed Fanoukh Aboqader Al-Aouadi, Natrayan Lakshmaiya, Roziyeva Muhayyo, Stefan Bräse, Hadeer M. Farhan   +8 more
doaj   +5 more sources

Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents [PDF]

BMC Chemistry, 2021
Background 1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory, analgesic, diabetic, immunosuppressive, α,β3-receptor antagonist ...
Ravi Kumar Bommera, Shashikala Kethireddy, Rajeshwar Reddy Govindapur, Laxminarayana Eppakayala   +3 more
doaj   +2 more sources

Synthesis and Antifungal Activity of 1,2,4-Oxadiazole Derivatives. [PDF]

Molecules
1,2,4-Oxadiazole derivatives containing anisic acid or cinnamic acid were designed and synthesized, which were expected to be an effective Succinate dehydrogenase (SDH) inhibitor, and their structures were characterized by 1H NMR, 13C NMR, and ESI-MS. The antifungal activity of the compounds against plant pathogenic fungi was screened by the mycelial ...
Yu L, Yang K, Yao L, Wang N, Kang H, Yao G, Li X, Qin B.   +7 more
europepmc   +4 more sources